4LMN
Crystal Structure of MEK1 kinase bound to GDC0973
Experimental procedure
Experimental method | SINGLE WAVELENGTH |
Source type | SYNCHROTRON |
Source details | SSRL BEAMLINE BL9-2 |
Synchrotron site | SSRL |
Beamline | BL9-2 |
Temperature [K] | 93 |
Detector technology | CCD |
Collection date | 2008-03-14 |
Detector | MARMOSAIC 325 mm CCD |
Wavelength(s) | 0.97 |
Spacegroup name | P 62 |
Unit cell lengths | 81.610, 81.610, 129.809 |
Unit cell angles | 90.00, 90.00, 120.00 |
Refinement procedure
Resolution | 29.690 - 2.800 |
R-factor | 0.1932 |
Rwork | 0.191 |
R-free | 0.23290 |
Structure solution method | MOLECULAR REPLACEMENT |
RMSD bond length | 0.010 |
RMSD bond angle | 1.280 |
Data reduction software | HKL-2000 |
Data scaling software | SCALEPACK |
Phasing software | AMoRE |
Refinement software | REFMAC (5.2.0005) |
Data quality characteristics
Overall | Outer shell | |
Low resolution limit [Å] | 30.000 | 2.900 |
High resolution limit [Å] | 2.800 | 2.800 |
Number of reflections | 12090 | |
<I/σ(I)> | 2.7 | 2.7 |
Completeness [%] | 99.9 | 100 |
Redundancy | 5.7 |
Crystallization Conditions
crystal ID | method | pH | temperature | details |
1 | VAPOR DIFFUSION, HANGING DROP | 6.9 | 291 | 12% w/v PEG 8000, 0.4M NH4H2PO4, 0.1M HEPES, pH 6.9, VAPOR DIFFUSION, HANGING DROP, temperature 291K |