2W1G

Structure determination of Aurora Kinase in complex with inhibitor

Experimental procedure

Experimental method	SINGLE WAVELENGTH
Source type	SYNCHROTRON
Source details	ESRF BEAMLINE ID14-4
Synchrotron site	ESRF
Beamline	ID14-4
Temperature [K]	100
Detector technology	CCD
Detector	ADSC CCD
Spacegroup name	P 61 2 2
Unit cell lengths	83.094, 83.094, 169.668
Unit cell angles	90.00, 90.00, 120.00

Refinement procedure

Resolution	66.250 - 2.710
R-factor	0.229
Rwork	0.225
R-free	0.29700
Structure solution method	OTHER
Starting model (for MR)	NONE
RMSD bond length	0.015
RMSD bond angle	1.525
Refinement software	REFMAC (5.4.0069A)

Data quality characteristics

	Overall
Low resolution limit [Å]	66.250
High resolution limit [Å]	2.710
Rmerge	0.050
Number of reflections	9350
<I/σ(I)>	4.3
Completeness [%]	98.4
Redundancy	3.2

Crystallization Conditions

crystal ID	method	pH	temperature	details
1