2W1F

Structure determination of Aurora Kinase in complex with inhibitor

Experimental procedure

Experimental method	SINGLE WAVELENGTH
Source type	SYNCHROTRON
Source details	ESRF BEAMLINE ID14-4
Synchrotron site	ESRF
Beamline	ID14-4
Temperature [K]	100
Detector technology	CCD
Detector	ADSC CCD
Spacegroup name	P 61 2 2
Unit cell lengths	82.527, 82.527, 168.443
Unit cell angles	90.00, 90.00, 120.00

Refinement procedure

Resolution	65.790 - 2.850
R-factor	0.246
Rwork	0.241
R-free	0.34800
Structure solution method	MOLECULAR REPLACEMENT
RMSD bond length	0.011
RMSD bond angle	1.290
Refinement software	REFMAC (5.4.0069A)

Data quality characteristics

	Overall
Low resolution limit [Å]	65.790
High resolution limit [Å]	2.850
Rmerge	0.060
Number of reflections	7793
<I/σ(I)>	5
Completeness [%]	97.6
Redundancy	4

Crystallization Conditions

crystal ID	method	pH	temperature	details
1