2YIX

Triazolopyridine Inhibitors of p38

Experimental procedure

Experimental method	SINGLE WAVELENGTH
Source type	ROTATING ANODE
Temperature [K]	100
Spacegroup name	P 21 21 21
Unit cell lengths	45.944, 86.523, 122.580
Unit cell angles	90.00, 90.00, 90.00

Refinement procedure

Resolution	24.750 - 2.300
R-factor	0.1959
Rwork	0.193
R-free	0.24720
Structure solution method	OTHER
Starting model (for MR)	NONE
RMSD bond length	0.010
RMSD bond angle	1.130
Refinement software	BUSTER (2.9.6)

Data quality characteristics

	Overall
Low resolution limit [Å]	25.000
High resolution limit [Å]	2.300
Rmerge	0.080
Number of reflections	21609
<I/σ(I)>	12
Completeness [%]	96.0
Redundancy	2.8

Crystallization Conditions

crystal ID	method	pH	temperature	details
1