2YIW

triazolopyridine inhibitors of p38 kinase

Experimental procedure

Experimental method	SINGLE WAVELENGTH
Source type	ROTATING ANODE
Temperature [K]	100
Spacegroup name	P 21 21 21
Unit cell lengths	64.580, 74.320, 76.820
Unit cell angles	90.00, 90.00, 90.00

Refinement procedure

Resolution	18.060 - 2.000
R-factor	0.2227
Rwork	0.221
R-free	0.25940
Structure solution method	OTHER
Starting model (for MR)	NONE
RMSD bond length	0.010
RMSD bond angle	1.080
Refinement software	BUSTER (2.9.6)

Data quality characteristics

	Overall
Low resolution limit [Å]	18.000
High resolution limit [Å]	2.000
Rmerge	0.050
Number of reflections	253061
Completeness [%]	99.4
Redundancy	3.4

Crystallization Conditions

crystal ID	method	pH	temperature	details
1