1O79
Structures of human oxidosqualene cyclase inhibitors bound to an homologous enzyme
Experimental procedure
Experimental method | SINGLE WAVELENGTH |
Source type | ROTATING ANODE |
Source details | RIGAKU RU200B |
Temperature [K] | 298 |
Detector technology | AREA DETECTOR |
Detector | SIEMENS |
Spacegroup name | P 32 2 1 |
Unit cell lengths | 141.289, 141.289, 245.397 |
Unit cell angles | 90.00, 90.00, 120.00 |
Refinement procedure
Resolution | 25.000 - 2.800 |
R-factor | 0.2394 |
Rwork | 0.239 |
R-free | 0.27280 |
Structure solution method | OTHER |
RMSD bond length | 0.005 |
RMSD bond angle | 1.100 |
Data reduction software | XDS |
Data scaling software | SCALA |
Refinement software | CNS (1.1) |
Data quality characteristics
Overall | |
Low resolution limit [Å] | 43.030 |
High resolution limit [Å] | 2.800 |
Rmerge | 0.137 |
Number of reflections | 54923 |
<I/σ(I)> | 4.4 |
Completeness [%] | 79.4 |
Redundancy | 3 |
Crystallization Conditions
crystal ID | method | pH | temperature | details |
1 | 4.8 | pH 4.80 |