1FVV

THE STRUCTURE OF CDK2/CYCLIN A IN COMPLEX WITH AN OXINDOLE INHIBITOR

Refinement Statistics

Experimental method:X-RAY DIFFRACTION (2.8 Å)

Cell axes184.952184.952212.832
Cell angles90.0090.00120.00
SpacegroupP 62 2 2
Resolution limits20.00 - 2.80
the highest resolution shell value -
R-factor0.21
R-work0.26000
R-free0.26000
RMSD bond length1.700 (0.009*)
RMSD bond angle0.010 (1.390*)

Data Collection Statistics

Resolution limits20.00 - 2.80
the highest resolution shell value -
Number of reflections50936
Number of measurements541713*
Rmerge_l_obs0.070
the highest resolution shell value0.290
Completeness95.9
Redundancy10
the highest resolution shell value9
I/sigma(I)0

Crystallization Conditions

crystal IDmethodpHpH rangetemperatureunit
1VAPOR DIFFUSION, HANGING DROP6.7 (7.5*)277 (20*)*

Crystallization Reagents

IDcrystal IDsolution IDreagent nameconcentrationdetails
Crystallization Reagents in Literatures*
IDcrystal IDsolutionreagent nameconcentration (unit)details
11dropprotein10 (mg/ml)
21dropHEPES20 (mM)
31dropEDTA1 (mM)
41reservoirPEG334010 (%)
Annotated Information is extracted from Literature Info*
Shewchuk L., (2000) J. Med. Chem., 43, 133.