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1QPE

STRUCTURAL ANALYSIS OF THE LYMPHOCYTE-SPECIFIC KINASE LCK IN COMPLEX WITH NON-SELECTIVE AND SRC FAMILY SELECTIVE KINASE INHIBITORS

Experimental procedure
Experimental methodSINGLE WAVELENGTH
Source typeROTATING ANODE
Source detailsRIGAKU RU300
Temperature [K]100
Detector technologyIMAGE PLATE
Collection date1999-02-07
DetectorRIGAKU RAXIS IIC
Spacegroup nameP 21 21 21
Unit cell lengths42.500, 74.090, 91.980
Unit cell angles90.00, 90.00, 90.00
Refinement procedure
Resolution5.000 - 2.000
R-factor0.189
Rwork0.189
R-free0.25400
RMSD bond length0.018
RMSD bond angle1.800
Data reduction softwareDENZO
Data scaling softwareSCALEPACK
Phasing softwareAMoRE
Refinement softwareX-PLOR (98.0)
Data quality characteristics
 OverallOuter shell
Low resolution limit [Å]20.0002.070
High resolution limit [Å]2.0002.000
Rmerge0.0820.198
Total number of observations53618

*

Number of reflections19946
<I/σ(I)>9.4
Completeness [%]93.090
Redundancy2.7
Crystallization Conditions
crystal IDmethodpHtemperaturedetails
1VAPOR DIFFUSION, HANGING DROP6.5293AMMONIUM SULPHATE, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Crystallization Reagents in Literatures
IDcrystal IDsolutionreagent nameconcentration (unit)details
11dropprotein5 (mM)
21reservoirammonium sulfate1.6 (M)
31reservoirBis-Tris0.1 (M)

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