1HPV

CRYSTAL STRUCTURE OF HIV-1 PROTEASE IN COMPLEX WITH VX-478, A POTENT AND ORALLY BIOAVAILABLE INHIBITOR OF THE ENZYME

Experimental procedure

Spacegroup name	P 61
Unit cell lengths	63.400, 63.400, 83.800
Unit cell angles	90.00, 90.00, 120.00

Refinement procedure

Resolution	8.000 - 1.900
R-factor	0.192
Rwork	0.192
RMSD bond length	0.011
RMSD bond angle	1.950
Phasing software	X-PLOR
Refinement software	X-PLOR

Data quality characteristics

	Overall
High resolution limit [Å]	1.900 *
Rmerge	0.071 *
Total number of observations	44734 *
Number of reflections	11037

Crystallization Conditions

crystal ID	method	pH	temperature	details
1