9LKT
 
 | | Human RNA Polymerase III de novo transcribing complex 10 (TC10) | | Descriptor: | 3'-DEOXYADENOSINE-5'-TRIPHOSPHATE, DNA (123-MER), DNA-directed RNA polymerase III subunit RPC1, ... | | Authors: | Wang, Q.M, Ren, Y.L, Jin, Q.W, Chen, X.Z, Xu, Y.H. | | Deposit date: | 2025-01-16 | | Release date: | 2025-04-16 | | Last modified: | 2025-07-30 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structural insights into human Pol III transcription initiation in action.
Nature, 643, 2025
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9LMS
 | | Crystal structure of Pichia pastoris-expressed FAST-PETase-N212A/K233C/S282C variant | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Poly(ethylene terephthalate) hydrolase | | Authors: | Li, X, Ning, Z.Y, Huang, S.Q, Zeng, C, Zeng, Z.Y, Ji, R, Huang, J.-W, Chen, C.-C, Guo, R.-T. | | Deposit date: | 2025-01-20 | | Release date: | 2025-07-23 | | Last modified: | 2025-07-30 | | Method: | X-RAY DIFFRACTION (1.71 Å) | | Cite: | Combined approaches to enhance the Pichia pastoris-expressed PET hydrolase.
Int.J.Biol.Macromol., 320, 2025
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9LMT
 | | Crystal structure of variant FAST-ACC-A248E | | Descriptor: | Poly(ethylene terephthalate) hydrolase | | Authors: | Li, X, Ning, Z.Y, Huang, S.Q, Zeng, C, Zeng, Z.Y, Ji, R, Huang, J.-W, Chen, C.-C, Guo, R.-T. | | Deposit date: | 2025-01-20 | | Release date: | 2025-07-23 | | Last modified: | 2025-07-30 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Combined approaches to enhance the Pichia pastoris-expressed PET hydrolase.
Int.J.Biol.Macromol., 320, 2025
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9LMU
 | | Crystal structure of variant FAST-ACC-A47E | | Descriptor: | Poly(ethylene terephthalate) hydrolase | | Authors: | Li, X, Ning, Z.Y, Huang, S.Q, Zeng, C, Zeng, Z.Y, Ji, R, Huang, J.-W, Chen, C.-C, Guo, R.-T. | | Deposit date: | 2025-01-20 | | Release date: | 2025-07-23 | | Last modified: | 2025-07-30 | | Method: | X-RAY DIFFRACTION (1.57 Å) | | Cite: | Combined approaches to enhance the Pichia pastoris-expressed PET hydrolase.
Int.J.Biol.Macromol., 320, 2025
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9LMV
 | | Crystal structure of FAST-ACC-T140D/R132G/S160A mutant in complex with mono(2-hydroxyethyl) terephthalic acid | | Descriptor: | 4-(2-hydroxyethyloxycarbonyl)benzoic acid, Poly(ethylene terephthalate) hydrolase | | Authors: | Li, X, Ning, Z.Y, Huang, S.Q, Zeng, C, Zeng, Z.Y, Ji, R, Huang, J.-W, Chen, C.-C, Guo, R.-T. | | Deposit date: | 2025-01-20 | | Release date: | 2025-07-23 | | Last modified: | 2025-07-30 | | Method: | X-RAY DIFFRACTION (1.57 Å) | | Cite: | Combined approaches to enhance the Pichia pastoris-expressed PET hydrolase.
Int.J.Biol.Macromol., 320, 2025
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9LMW
 | | Crystal structure of variant FAST-ACC-T140E | | Descriptor: | Poly(ethylene terephthalate) hydrolase | | Authors: | Li, X, Ning, Z.Y, Huang, S.Q, Zeng, C, Zeng, Z.Y, Ji, R, Huang, J.-W, Chen, C.-C, Guo, R.-T. | | Deposit date: | 2025-01-20 | | Release date: | 2025-07-23 | | Last modified: | 2025-07-30 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Combined approaches to enhance the Pichia pastoris-expressed PET hydrolase.
Int.J.Biol.Macromol., 320, 2025
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9LMX
 | | Inactive mutant of FAST-ACC-T140E/R132G in complex with mono(2-hydroxyethyl) terephthalic acid | | Descriptor: | 4-(2-hydroxyethyloxycarbonyl)benzoic acid, Poly(ethylene terephthalate) hydrolase | | Authors: | Li, X, Ning, Z.Y, Huang, S.Q, Zeng, C, Zeng, Z.Y, Ji, R, Huang, J.-W, Chen, C.-C, Guo, R.-T. | | Deposit date: | 2025-01-20 | | Release date: | 2025-07-23 | | Last modified: | 2025-07-30 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Combined approaches to enhance the Pichia pastoris-expressed PET hydrolase.
Int.J.Biol.Macromol., 320, 2025
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9LN5
 | | Crystal structure of P450revI A241L mutant in complex with reveromycin T | | Descriptor: | (2E,4S,5S,6E,8E)-10-{(2R,3S,6S,8R,9S)-9-butyl-8-[(1E,3E)-4-carboxy-3-methylbuta-1,3-dien-1-yl]-3-methyl-1,7-dioxaspiro[5.5]undec-2-yl}-5-hydroxy-4,8-dimethyldeca-2,6,8-trienoic acid, CHLORIDE ION, PROTOPORPHYRIN IX CONTAINING FE, ... | | Authors: | Fujiyama, K, Yong, Y.F, Takahashi, S. | | Deposit date: | 2025-01-20 | | Release date: | 2025-07-02 | | Last modified: | 2025-07-30 | | Method: | X-RAY DIFFRACTION (2.13 Å) | | Cite: | Biosynthesis of reveromycin derivatives by altering the regioselectivity of cytochrome P450revI.
Chem Sci, 16, 2025
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9LR5
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9LXN
 | | Human RNA Polymerase III de novo transcribing complex 5 (TC5)(without 3'dATP) | | Descriptor: | DNA (127-MER), DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, ... | | Authors: | Wang, Q, Ren, Y, Jin, Q, Chen, X, Xu, Y. | | Deposit date: | 2025-02-18 | | Release date: | 2025-04-16 | | Last modified: | 2025-07-30 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural insights into human Pol III transcription initiation in action.
Nature, 643, 2025
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9LXO
 | | Human RNA Polymerase III de novo transcribing complex 6 (TC6)(without 3'dATP) | | Descriptor: | DNA (127-MER), DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, ... | | Authors: | Wang, Q, Ren, Y, Jin, Q, Chen, X, Xu, Y. | | Deposit date: | 2025-02-18 | | Release date: | 2025-04-16 | | Last modified: | 2025-07-30 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structural insights into human Pol III transcription initiation in action.
Nature, 643, 2025
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9M5M
 | | Crystal structure of Plasmodium vivax aspartyl-tRNA synthetase (PvDRS) | | Descriptor: | 1,2-ETHANEDIOL, SULFATE ION, aspartate--tRNA ligase | | Authors: | Sharma, V.K, Manickam, Y, Bagale, S, Pradeepkumar, P.I, Sharma, A. | | Deposit date: | 2025-03-06 | | Release date: | 2025-06-04 | | Last modified: | 2025-07-30 | | Method: | X-RAY DIFFRACTION (2.06 Å) | | Cite: | Natural product-mediated reaction hijacking mechanism validates Plasmodium aspartyl-tRNA synthetase as an antimalarial drug target.
Plos Pathog., 21, 2025
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9M5N
 | | Plasmodium vivax aspartyl-tRNA synthetase in complex with aspartyl-adenylate (Asp-AMP) Complex. | | Descriptor: | ACETATE ION, ASPARTYL-ADENOSINE-5'-MONOPHOSPHATE, GLYCEROL, ... | | Authors: | Sharma, V.K, Manickam, Y, Sharma, A, Bagale, S, Pradeepkumar, P.I. | | Deposit date: | 2025-03-06 | | Release date: | 2025-06-04 | | Last modified: | 2025-07-30 | | Method: | X-RAY DIFFRACTION (2.14 Å) | | Cite: | Natural product-mediated reaction hijacking mechanism validates Plasmodium aspartyl-tRNA synthetase as an antimalarial drug target.
Plos Pathog., 21, 2025
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9M5O
 | | Plasmodium vivax aspartyl-tRNA synthetase in complex with aspartyl sulfamoyl adenosine (Asp-AMS) Complex | | Descriptor: | 5'-O-(L-alpha-aspartylsulfamoyl)adenosine, MAGNESIUM ION, aspartate--tRNA ligase | | Authors: | Sharma, V.K, Manickam, Y, Sharma, A, Bagale, S, Pradeepkumar, P.I. | | Deposit date: | 2025-03-06 | | Release date: | 2025-06-04 | | Last modified: | 2025-07-30 | | Method: | X-RAY DIFFRACTION (1.839 Å) | | Cite: | Natural product-mediated reaction hijacking mechanism validates Plasmodium aspartyl-tRNA synthetase as an antimalarial drug target.
Plos Pathog., 21, 2025
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9M8M
 | | Structure of photosynthetic LH1-RC complex the Halophilic Nonsulfur Purple Bacterium, Rhodothalassium salexigens | | Descriptor: | (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, (2S)-3-hydroxypropane-1,2-diyl dihexadecanoate, BACTERIOCHLOROPHYLL A, ... | | Authors: | Tani, K, Kanno, R, Inami, M, Ooya, T, Matsushita, R, Minamino, A, Takenaka, S, Takaichi, S, Purba, E.R, Hall, M, Mochizuki, T, Yu, L.-J, Mizoguchi, A, Humbel, B.M, Madigan, M.T, Kimura, Y, Wang-Otomo, Z.-Y. | | Deposit date: | 2025-03-12 | | Release date: | 2025-07-02 | | Last modified: | 2025-07-30 | | Method: | ELECTRON MICROSCOPY (2.3 Å) | | Cite: | Structure and Biochemistry of the LH1-RC Photocomplex from the Halophilic Purple Bacterium, Rhodothalassium salexigens .
Biochemistry, 64, 2025
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9MCW
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9MDS
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9MEE
 | | GOLLD RNA nanocage (env-38) | | Descriptor: | GOLLD RNA nanocage | | Authors: | Kretsch, R.C, Wu, Y, Nye, G, Das, R, Chiu, W. | | Deposit date: | 2024-12-06 | | Release date: | 2025-04-30 | | Last modified: | 2025-07-30 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Naturally ornate RNA-only complexes revealed by cryo-EM.
Nature, 643, 2025
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9MGK
 | | Human prostaglandin transporter(OATP2A1) | | Descriptor: | Digitonin, Solute carrier organic anion transporter family member 2A1 | | Authors: | Yu, P, Orlando, M.A, Orlando, B.J. | | Deposit date: | 2024-12-11 | | Release date: | 2025-07-23 | | Last modified: | 2025-07-30 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | Structure and post-translational modification of the prostaglandin transporter.
Commun Biol, 8, 2025
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9MOE
 | | Preclinical and clinical evaluation of a novel TRPA1 antagonist LY3526318 | | Descriptor: | (2S)-2-{3-methyl-1-[(3-methyl-1,2,4-oxadiazol-5-yl)methyl]-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl}-N-{6-[2-(trifluoromethyl)pyrimidin-5-yl]pyridin-2-yl}propanamide, Transient receptor potential cation channel subfamily A member 1 | | Authors: | Nie, S. | | Deposit date: | 2024-12-26 | | Release date: | 2025-05-21 | | Last modified: | 2025-07-30 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Preclinical and clinical evaluation of a novel TRPA1 antagonist LY3526318.
Pain, 166, 2025
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9MR5
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9N3H
 | | Crystal structure of HBV capsid with compound 18 | | Descriptor: | Capsid protein, N-[3-(difluoromethyl)phenyl]-5-[{[(1s,4s)-4-hydroxycyclohexyl]amino}(oxo)acetyl]-1,2,4-trimethyl-1H-pyrrole-3-carboxamide | | Authors: | White, A, Lakshminarasimhan, D, Cakici, O, Suto, R. | | Deposit date: | 2025-01-31 | | Release date: | 2025-07-02 | | Last modified: | 2025-07-30 | | Method: | X-RAY DIFFRACTION (2.543 Å) | | Cite: | Discovery of VNRX-9945, a Potent, Broadly Active Capsid Assembly Modulator as a Clinical Candidate for the Treatment of Chronic Hepatitis B Virus Infection.
Acs Med.Chem.Lett., 16, 2025
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9N4V
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9N4W
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9N4Y
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