9BYI
 
 | | Structure of human K2P13.1 (THIK1) in detergent | | Descriptor: | DODECANE, HEXADECANE, HEXANE, ... | | Authors: | Roy-Chowdhury, S, Minor, D.L. | | Deposit date: | 2024-05-23 | | Release date: | 2025-02-26 | | Last modified: | 2025-07-30 | | Method: | ELECTRON MICROSCOPY (2.95 Å) | | Cite: | Structure of the human K 2P 13.1 channel reveals a hydrophilic pore restriction and lipid cofactor site.
Nat.Struct.Mol.Biol., 32, 2025
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9C07
 | | Structure of K2P13.1 (THIK1) S136P in detergent | | Descriptor: | DODECANE, HEXADECANE, HEXANE, ... | | Authors: | Roy-Chowdhury, S, Adberemane-Ali, F, Minor, D.L. | | Deposit date: | 2024-05-24 | | Release date: | 2025-02-26 | | Last modified: | 2025-07-30 | | Method: | ELECTRON MICROSCOPY (2.73 Å) | | Cite: | Structure of the human K 2P 13.1 channel reveals a hydrophilic pore restriction and lipid cofactor site.
Nat.Struct.Mol.Biol., 32, 2025
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9C09
 | | Structure of K2P13.1 (THIK1) S136P in lipid nanodisc | | Descriptor: | DECANE, DODECANE, HEXANE, ... | | Authors: | Roy-Chowdhury, S, Adberemane-Ali, F, Minor, D.L. | | Deposit date: | 2024-05-24 | | Release date: | 2025-02-26 | | Last modified: | 2025-07-30 | | Method: | ELECTRON MICROSCOPY (2.36 Å) | | Cite: | Structure of the human K 2P 13.1 channel reveals a hydrophilic pore restriction and lipid cofactor site.
Nat.Struct.Mol.Biol., 32, 2025
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9C2H
 | | SARS-CoV-2 Nucleocapsid Dimerization Domain bound to Fab-NP1E9 and Fab-NP3B4 | | Descriptor: | Antibody Fab NP1-E9 Heavy Chain (variable region), Antibody Fab NP1-E9 Light Chain (variable region), Antibody Fab NP3-B4 Heavy Chain (variable region), ... | | Authors: | Landeras-Bueno, S, Hariharan, C, Diaz Avalos, R, Ollmann Saphire, E. | | Deposit date: | 2024-05-31 | | Release date: | 2025-05-14 | | Last modified: | 2025-07-30 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Structural stabilization of the intrinsically disordered SARS-CoV-2 N by binding to RNA sequences engineered from the viral genome fragment.
Nat Commun, 16, 2025
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9C9G
 | | S.c INO80 in complex with S.c 0/80 nucleosome | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin-related protein 5, Chromatin-remodeling ATPase INO80, ... | | Authors: | Wu, H, Kaur, U, Narlikar, G.J, Cheng, Y.F. | | Deposit date: | 2024-06-13 | | Release date: | 2025-07-16 | | Last modified: | 2025-07-30 | | Method: | ELECTRON MICROSCOPY (2.91 Å) | | Cite: | Autoinhibition imposed by a large conformational switch of INO80 regulates nucleosome positioning.
Science, 389, 2025
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9C9S
 | | S.c INO80 in complex with S.c 0/40 nucleosome, Class 1 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin-related protein 5, Chromatin-remodeling ATPase INO80, ... | | Authors: | Wu, H, Kaur, U, Narlikar, G.J, Cheng, Y.F. | | Deposit date: | 2024-06-15 | | Release date: | 2025-07-16 | | Last modified: | 2025-07-30 | | Method: | ELECTRON MICROSCOPY (3.09 Å) | | Cite: | Autoinhibition imposed by a large conformational switch of INO80 regulates nucleosome positioning.
Science, 389, 2025
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9C9T
 | | S.c INO80 in complex with S.c 0/40 nucleosome, Class 2 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin-related protein 5, Chromatin-remodeling ATPase INO80, ... | | Authors: | Wu, H, Kaur, U, Narlikar, G.J, Cheng, Y.F. | | Deposit date: | 2024-06-15 | | Release date: | 2025-07-16 | | Last modified: | 2025-07-30 | | Method: | ELECTRON MICROSCOPY (3.16 Å) | | Cite: | Autoinhibition imposed by a large conformational switch of INO80 regulates nucleosome positioning.
Science, 389, 2025
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9C9X
 | | S.c INO80 in complex with Xenopus 0/80 nucleosome, Nucleosome | | Descriptor: | DNA (227-MER), Histone H2A, Histone H2B 1.1, ... | | Authors: | Wu, H, Kaur, U, Narlikar, G.J, Cheng, Y.F. | | Deposit date: | 2024-06-16 | | Release date: | 2025-07-16 | | Last modified: | 2025-07-30 | | Method: | ELECTRON MICROSCOPY (2.83 Å) | | Cite: | Autoinhibition imposed by a large conformational switch of INO80 regulates nucleosome positioning.
Science, 389, 2025
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9C9Z
 | | S.c INO80 in complex with Xenopus 0/80 nucleosome, INO80 Core | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin-related protein 5, Chromatin-remodeling ATPase INO80, ... | | Authors: | Wu, H, Kaur, U, Narlikar, G.J, Cheng, Y.F. | | Deposit date: | 2024-06-16 | | Release date: | 2025-07-16 | | Last modified: | 2025-07-30 | | Method: | ELECTRON MICROSCOPY (2.55 Å) | | Cite: | Autoinhibition imposed by a large conformational switch of INO80 regulates nucleosome positioning.
Science, 389, 2025
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9CAN
 | | S.c INO80 in complex with Xenopus 0/40 nucleosome | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin-related protein 5, Chromatin-remodeling ATPase INO80, ... | | Authors: | Wu, H, Kaur, U, Narlikar, G.J, Cheng, Y.F. | | Deposit date: | 2024-06-17 | | Release date: | 2025-07-16 | | Last modified: | 2025-07-30 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Autoinhibition imposed by a large conformational switch of INO80 regulates nucleosome positioning.
Science, 389, 2025
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9CAT
 | | DeltaArp8 INO80 bound to S.c 0/40 nucleosome, INO80 Core Module | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin-related protein 5, Chromatin-remodeling ATPase INO80, ... | | Authors: | Wu, H, Kaur, U, Narlikar, G.J, Cheng, Y.F. | | Deposit date: | 2024-06-17 | | Release date: | 2025-07-16 | | Last modified: | 2025-07-30 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Autoinhibition imposed by a large conformational switch of INO80 regulates nucleosome positioning.
Science, 389, 2025
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9CAU
 | | DeltaArp8 INO80 bound to S.c 0/40 nucleosome, Nucleosome | | Descriptor: | DNA (227-MER), Histone H2A.1, Histone H2B.1, ... | | Authors: | Wu, H, Kaur, U, Narlikar, G.J, Cheng, Y.F. | | Deposit date: | 2024-06-17 | | Release date: | 2025-07-16 | | Last modified: | 2025-07-30 | | Method: | ELECTRON MICROSCOPY (4.18 Å) | | Cite: | Autoinhibition imposed by a large conformational switch of INO80 regulates nucleosome positioning.
Science, 389, 2025
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9CB7
 | | DeltaNhp10 INO80 bound to S.c 0/40 nucleosome, Ino80-Nucleosome | | Descriptor: | Chromatin-remodeling ATPase INO80, DNA (227-MER), Histone H2A.1, ... | | Authors: | Wu, H, Kaur, U, Narlikar, G.J, Cheng, Y.F. | | Deposit date: | 2024-06-18 | | Release date: | 2025-07-16 | | Last modified: | 2025-07-30 | | Method: | ELECTRON MICROSCOPY (4.04 Å) | | Cite: | Autoinhibition imposed by a large conformational switch of INO80 regulates nucleosome positioning.
Science, 389, 2025
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9CB8
 | | Crystal structure of dihydroorotate dehydrogenase from Leishmania brasiliensis in complex with 5-benzylidenepyrimidine-2,4,6(1H,3H,5H)-trione | | Descriptor: | 5-benzyl-1,3-diazinane-2,4,6-trione, Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, ... | | Authors: | Froes, T.Q, Vaidergorn, M.M, dos Santos, T, Leite, P.I.P.L, Godoi, B.F, Emery, F.S, Nonato, M.C. | | Deposit date: | 2024-06-18 | | Release date: | 2025-06-25 | | Last modified: | 2025-07-30 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Barbituric Acid Derivatives as Covalent Inhibitors of Leishmania braziliensis Dihydroorotate Dehydrogenase.
J.Med.Chem., 2025
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9CCD
 | | DeltaNhp10 INO80 bound to S.c 0/40 nucleosome, INO80 core module | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Actin-related protein 5, Chromatin-remodeling ATPase INO80, ... | | Authors: | Wu, H, Kaur, U, Narlikar, G.J, Cheng, Y.F. | | Deposit date: | 2024-06-21 | | Release date: | 2025-07-16 | | Last modified: | 2025-07-30 | | Method: | ELECTRON MICROSCOPY (3.01 Å) | | Cite: | Autoinhibition imposed by a large conformational switch of INO80 regulates nucleosome positioning.
Science, 389, 2025
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9CCI
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9CCJ
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9CQ3
 | | The gap-filling complex with Pol mu engaged in the NHEJ pathway | | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (34-MER), DNA (37-MER), ... | | Authors: | Li, J, Liu, L, Gellert, M, Yang, W. | | Deposit date: | 2024-07-19 | | Release date: | 2025-04-23 | | Last modified: | 2025-07-30 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Dynamic assemblies and coordinated reactions of non-homologous end joining.
Nature, 643, 2025
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9CQ6
 | | The ligation complex in the NHEJ pathway | | Descriptor: | ADENOSINE MONOPHOSPHATE, DNA (34-MER), DNA (36-MER), ... | | Authors: | Li, J, Liu, L, Gellert, M, Yang, W. | | Deposit date: | 2024-07-19 | | Release date: | 2025-04-23 | | Last modified: | 2025-07-30 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Dynamic assemblies and coordinated reactions of non-homologous end joining.
Nature, 643, 2025
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9CQC
 | | The ligation complex like in the NHEJ pathway | | Descriptor: | 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (34-MER), DNA (35-MER), ... | | Authors: | Li, J, Liu, L, Gellert, M, Yang, W. | | Deposit date: | 2024-07-19 | | Release date: | 2025-04-23 | | Last modified: | 2025-07-30 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Dynamic assemblies and coordinated reactions of non-homologous end joining.
Nature, 643, 2025
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9D6L
 | | Human Sec61 complex inhibited by KZR-261 | | Descriptor: | 4-{(3S)-9-(cyclohexylmethyl)-5-[(3R,5R)-4-(3-fluoro-5-methoxyphenyl)-3,5-dimethylpiperazine-1-sulfonyl]-3-methyl-1,5,9-triazacyclododecane-1-sulfonyl}-N,N-dimethylaniline, Protein transport protein Sec61 subunit alpha isoform 1, Protein transport protein Sec61 subunit beta, ... | | Authors: | Park, E, Wang, L. | | Deposit date: | 2024-08-15 | | Release date: | 2025-07-23 | | Last modified: | 2025-07-30 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Preclinical characterization of novel multi-client inhibitors of Sec61 with broad antitumor activity.
J.Pharmacol.Exp.Ther., 392, 2025
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9DAF
 | | L-asparaginase II (EcA2-K12) | | Descriptor: | ACETIC ACID, ASPARTIC ACID, DI(HYDROXYETHYL)ETHER, ... | | Authors: | de Sa Ribeiro, F, Costa, A.C, Araujo, T.S, Almeida, M.S, Lima, L.M.T.R. | | Deposit date: | 2024-08-22 | | Release date: | 2025-05-21 | | Last modified: | 2025-07-30 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Biochemical and Biophysical Divergences between Two Escherichia coli l-Asparaginase II Variants: Potential for Using EcA2-K12 as a Biosimilar.
Biochemistry, 64, 2025
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9DAH
 | | L-asparaginase II (EcA2-4M) | | Descriptor: | ASPARTIC ACID, L-asparaginase 2 | | Authors: | de Sa Ribeiro, F, Costa, A.C, Araujo, T.S, Almeida, M.S, Lima, L.M.T.R. | | Deposit date: | 2024-08-22 | | Release date: | 2025-06-04 | | Last modified: | 2025-07-30 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Biochemical and Biophysical Divergences between Two Escherichia coli l-Asparaginase II Variants: Potential for Using EcA2-K12 as a Biosimilar.
Biochemistry, 64, 2025
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9DBI
 | | Structure of Hailong HalB D21A/D23A mutant | | Descriptor: | HalB, PHOSPHATE ION | | Authors: | Tan, J.M.J, Melamed, S, Cofsky, J.C, Hobbs, S.J, Kruse, A.C, Sorek, R, Kranzusch, P.J. | | Deposit date: | 2024-08-23 | | Release date: | 2025-05-07 | | Last modified: | 2025-07-30 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | A DNA-gated molecular guard controls bacterial Hailong anti-phage defence.
Nature, 643, 2025
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9DBJ
 | | Structure of Hailong HalB R164A mutant with non-hydrolyzable dATP | | Descriptor: | (2R)-2-amino-3-(4-{[(R)-{[(2R,3R,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl]oxy}phenyl)propanoic acid (non-preferred name), (2R)-3-(4-{[(S)-{[(2R,3R,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl]oxy}phenyl)-2-{[(2R)-pyrrolidine-2-carbonyl]amino}propanoic acid (non-preferred name), 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, ... | | Authors: | Tan, J.M.J, Melamed, S, Cofsky, J.C, Hobbs, S.J, Kruse, A.C, Sorek, R, Kranzusch, P.J. | | Deposit date: | 2024-08-23 | | Release date: | 2025-05-07 | | Last modified: | 2025-07-30 | | Method: | X-RAY DIFFRACTION (2.41 Å) | | Cite: | A DNA-gated molecular guard controls bacterial Hailong anti-phage defence.
Nature, 643, 2025
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