10AD
 
 | | Cryo-EM structure of the human BK channel bound to the agonist NS1619 | | Descriptor: | 3-[2-oxidanyl-5-(trifluoromethyl)phenyl]-6-(trifluoromethyl)-1~{H}-benzimidazol-2-one, CALCIUM ION, Isoform 5 of Calcium-activated potassium channel subunit alpha-1, ... | | Authors: | Gonzalez-Sanabria, N, Contreras, G.F, Perozo, E, Latorre, R. | | Deposit date: | 2026-01-08 | | Release date: | 2026-02-04 | | Last modified: | 2026-10-07 | | Method: | ELECTRON MICROSCOPY (3.44 Å) | | Cite: | The BK channel-NS1619 agonist complex reveals molecular insights into allosteric activation gating.
Proc.Natl.Acad.Sci.USA, 123, 2026
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11OS
 | | Crystal Structure of Honey Truffle Active Component 1 through 4 (Orthorhombic P form) | | Descriptor: | CHLORIDE ION, HEXAETHYLENE GLYCOL, Honey Truffle Active Component 1 through 4 | | Authors: | Lovell, S, Cooper, A, Connors, D.E, Pitkanen, T.T, McFarland, C.T, Vo, P, Patnaik, R. | | Deposit date: | 2026-03-06 | | Release date: | 2026-09-23 | | Last modified: | 2026-10-07 | | Method: | X-RAY DIFFRACTION (1.23 Å) | | Cite: | Crystal structures of the sweet-tasting protein honey truffle active component from Mattirolomyces terfezioides
Acta Crystallogr.,Sect.F, 82, 2026
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11OT
 | | Crystal Structure of Honey Truffle Active Component 1 through 4 with HEPES bound (Orthorhombic P form) | | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ACETATE ION, Honey Truffle Active Component 1 through 4, ... | | Authors: | Lovell, S, Cooper, A, Connors, D.E, Pitkanen, T.T, McFarland, C.T, Vo, P, Patnaik, R. | | Deposit date: | 2026-03-06 | | Release date: | 2026-09-23 | | Last modified: | 2026-10-07 | | Method: | X-RAY DIFFRACTION (1.25 Å) | | Cite: | Crystal structures of the sweet-tasting protein honey truffle active component from Mattirolomyces terfezioides
Acta Crystallogr.,Sect.F, 82, 2026
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11OW
 | | Crystal Structure of Honey Truffle Active Component 1 through 4 with 1,4-butanediol bound (Orthorhombic P form) | | Descriptor: | 1,4-BUTANEDIOL, 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, CHLORIDE ION, ... | | Authors: | Lovell, S, Cooper, A, Connors, D.E, Pitkanen, T.T, McFarland, C.T, Vo, P, Patnaik, R. | | Deposit date: | 2026-03-06 | | Release date: | 2026-09-23 | | Last modified: | 2026-10-07 | | Method: | X-RAY DIFFRACTION (1.18 Å) | | Cite: | Crystal structures of the sweet-tasting protein honey truffle active component from Mattirolomyces terfezioides
Acta Crystallogr.,Sect.F, 82, 2026
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11OX
 | | Crystal Structure of Honey Truffle Active Component 1 through 4 with glucose bound (Monoclinic P form) | | Descriptor: | CHLORIDE ION, Honey Truffle Active Component 1 through 4, beta-D-glucopyranose | | Authors: | Lovell, S, Cooper, A, Connors, D.E, Pitkanen, T.T, McFarland, C.T, Vo, P, Patnaik, R. | | Deposit date: | 2026-03-06 | | Release date: | 2026-09-23 | | Last modified: | 2026-10-07 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Crystal structures of the sweet-tasting protein honey truffle active component from Mattirolomyces terfezioides
Acta Crystallogr.,Sect.F, 82, 2026
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11RO
 | | Crystal Structure of SARS-CoV-2 Mpro with UM-005 | | Descriptor: | 3C-like proteinase nsp5, N-(trifluoroacetyl)-D-phenylalanyl-N-{(1Z,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-phenylalaninamide | | Authors: | Shaqra, A.M, Adnan, S.F.Z, Lee, L.T, Iyer, V, Jung, K, Intravaia, L.E, Kaur, J, Schiffer, C.A. | | Deposit date: | 2026-03-10 | | Release date: | 2026-04-22 | | Last modified: | 2026-10-07 | | Method: | X-RAY DIFFRACTION (2.71 Å) | | Cite: | Nitrile-Based Inhibitors Targeting both SARS-CoV‐2 Main Protease and Human Cathepsin L.
Acs Med.Chem.Lett., 17, 2026
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11XB
 | | Cryo-EM of Hxc endopilus | | Descriptor: | CALCIUM ION, Type II secretion system core protein G | | Authors: | Sonani, R.R, Ball, G, Chouikha, I, Durand, E, Voulhoux, R, Egelman, E.H. | | Deposit date: | 2026-03-17 | | Release date: | 2026-09-23 | | Last modified: | 2026-10-07 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structures of the Xcp and Hxc T2SS endopili provide new insights into type IV pili subfamilies.
Structure, 34, 2026
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11XC
 | | Cryo-EM of Xcp endopilus | | Descriptor: | CALCIUM ION, Type II secretion system core protein G | | Authors: | Sonani, R.R, Ball, G, Chouikha, I, Durand, E, Voulhoux, R, Egelman, E.H. | | Deposit date: | 2026-03-17 | | Release date: | 2026-09-23 | | Last modified: | 2026-10-07 | | Method: | ELECTRON MICROSCOPY (4.6 Å) | | Cite: | Structures of the Xcp and Hxc T2SS endopili provide new insights into type IV pili subfamilies.
Structure, 34, 2026
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12AF
 | | Crystal Structure of SARS-CoV-2 Mpro with UM-067 | | Descriptor: | 3C-like proteinase nsp5, GLYCEROL, N-(trifluoroacetyl)-D-phenylalanyl-3-cyclopropyl-N-{(1Z,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-alaninamide, ... | | Authors: | Shaqra, A.M, Adnan, S.F.Z, Lee, L.T, Iyer, V, Jung, K, Intravaia, L.E, Kaur, J, Schiffer, C.A. | | Deposit date: | 2026-03-22 | | Release date: | 2026-04-22 | | Last modified: | 2026-10-07 | | Method: | X-RAY DIFFRACTION (1.87 Å) | | Cite: | Nitrile-Based Inhibitors Targeting both SARS-CoV‐2 Main Protease and Human Cathepsin L.
Acs Med.Chem.Lett., 17, 2026
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12QH
 | | Room Temperature X-Ray Structure of SARS-CoV-2 Main Protease in Complex with noncovalent inhibitor KK-1 | | Descriptor: | 3C-like proteinase nsp5, 5-fluoro-6-[4-(3,4,5-trichlorophenyl)piperazine-1-carbonyl]pyrimidine-2,4(1H,3H)-dione, SODIUM ION | | Authors: | Bhandari, D, Kovalevsky, A. | | Deposit date: | 2026-04-15 | | Release date: | 2026-09-09 | | Last modified: | 2026-10-07 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Noncovalent SARS-CoV-2 main protease inhibitors targeting the catalytic dyad and primed substrate binding subsites.
Rsc Med Chem, 17, 2026
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12SV
 | | Room Temperature X-Ray Structure of SARS-CoV-2 Main Protease in Complex with noncovalent inhibitor KK-2 | | Descriptor: | 3C-like proteinase nsp5, 5-chloro-6-[4-(3,4,5-trichlorophenyl)piperazine-1-carbonyl]pyrimidine-2,4(1H,3H)-dione, SODIUM ION | | Authors: | Bhandari, D, Kovalevsky, A. | | Deposit date: | 2026-04-17 | | Release date: | 2026-09-09 | | Last modified: | 2026-10-07 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Noncovalent SARS-CoV-2 main protease inhibitors targeting the catalytic dyad and primed substrate binding subsites.
Rsc Med Chem, 17, 2026
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12TA
 | | Room Temperature X-Ray Structure of SARS-CoV-2 Main Protease in Complex with noncovalent inhibitor KK-3 | | Descriptor: | 3C-like proteinase nsp5, 5-methyl-6-[4-(3,4,5-trichlorophenyl)piperazine-1-carbonyl]pyrimidine-2,4(1H,3H)-dione, SODIUM ION | | Authors: | Bhandari, D, Kovalevsky, A. | | Deposit date: | 2026-04-17 | | Release date: | 2026-09-09 | | Last modified: | 2026-10-07 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Noncovalent SARS-CoV-2 main protease inhibitors targeting the catalytic dyad and primed substrate binding subsites.
Rsc Med Chem, 17, 2026
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12WC
 | | Room Temperature X-Ray Structure of SARS-CoV-2 Main Protease in Complex with noncovalent inhibitor KK-7 | | Descriptor: | 3C-like proteinase nsp5, 5-fluoro-6-[4-(3,4,5-trichlorophenyl)piperazine-1-carbonyl]pyrimidine-2,4(1H,3H)-dione, SODIUM ION | | Authors: | Bhandari, D, Kovalevsky, A. | | Deposit date: | 2026-04-20 | | Release date: | 2026-09-09 | | Last modified: | 2026-10-07 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Noncovalent SARS-CoV-2 main protease inhibitors targeting the catalytic dyad and primed substrate binding subsites.
Rsc Med Chem, 17, 2026
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12XD
 | | Room Temperature X-Ray Structure of SARS-CoV-2 Main Protease in Complex with noncovalent inhibitor KB-1 | | Descriptor: | 3C-like proteinase nsp5, N-{4,5-dichloro-2-[4-(2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carbonyl)piperazin-1-yl]phenyl}-4-methylbenzene-1-sulfonamide | | Authors: | Bhandari, D, Kovalevsky, A. | | Deposit date: | 2026-04-21 | | Release date: | 2026-09-09 | | Last modified: | 2026-10-07 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Noncovalent SARS-CoV-2 main protease inhibitors targeting the catalytic dyad and primed substrate binding subsites.
Rsc Med Chem, 17, 2026
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12YF
 | | Room Temperature X-Ray Structure of SARS-CoV-2 Main Protease in Complex with noncovalent inhibitor KB-2 | | Descriptor: | 3C-like proteinase nsp5, N-{4,5-dichloro-2-[4-(2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carbonyl)piperazin-1-yl]phenyl}cyclopropanesulfonamide, SODIUM ION | | Authors: | Bhandari, D, Kovalevsky, A. | | Deposit date: | 2026-04-22 | | Release date: | 2026-09-09 | | Last modified: | 2026-10-07 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Noncovalent SARS-CoV-2 main protease inhibitors targeting the catalytic dyad and primed substrate binding subsites.
Rsc Med Chem, 17, 2026
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12ZG
 | | Room Temperature X-Ray Structure of SARS-CoV-2 Main Protease in Complex with noncovalent inhibitor KB-3 | | Descriptor: | 3C-like proteinase nsp5, N-{4,5-dichloro-2-[4-(2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carbonyl)piperazin-1-yl]phenyl}cyclopropanecarboxamide, SODIUM ION | | Authors: | Bhandari, D, Kovalevsky, A. | | Deposit date: | 2026-04-24 | | Release date: | 2026-09-09 | | Last modified: | 2026-10-07 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Noncovalent SARS-CoV-2 main protease inhibitors targeting the catalytic dyad and primed substrate binding subsites.
Rsc Med Chem, 17, 2026
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12ZL
 | | Room Temperature X-Ray Structure of SARS-CoV-2 Main Protease in Complex with noncovalent inhibitor KB-4 | | Descriptor: | 3C-like proteinase nsp5, N-{4,5-dichloro-2-[4-(5-fluoro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carbonyl)piperazin-1-yl]phenyl}cyclopropanecarboxamide, SODIUM ION | | Authors: | Bhandari, D, Kovalevsky, A. | | Deposit date: | 2026-04-24 | | Release date: | 2026-09-09 | | Last modified: | 2026-10-07 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Noncovalent SARS-CoV-2 main protease inhibitors targeting the catalytic dyad and primed substrate binding subsites.
Rsc Med Chem, 17, 2026
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13BW
 | | Room Temperature X-Ray Structure of SARS-CoV-2 Main Protease in Complex with noncovalent inhibitor KB-6 | | Descriptor: | 3C-like proteinase nsp5, N-{4,5-dichloro-2-[4-(5-fluoro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carbonyl)piperazin-1-yl]phenyl}cyclopentanecarboxamide, SODIUM ION | | Authors: | Bhandari, D, Kovalevsky, A. | | Deposit date: | 2026-04-28 | | Release date: | 2026-09-09 | | Last modified: | 2026-10-07 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Noncovalent SARS-CoV-2 main protease inhibitors targeting the catalytic dyad and primed substrate binding subsites.
Rsc Med Chem, 17, 2026
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13CH
 | | RT XFEL structure of one-flash state of Photosystem II (1F, S2 rich) at 2.02 Angstrom | | Descriptor: | 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, ... | | Authors: | Bhowmick, A, Kern, J, Yano, J, Yachandra, V.K, Bogacz, I, Chatterjee, R, Zhang, M. | | Deposit date: | 2026-04-28 | | Release date: | 2026-09-23 | | Last modified: | 2026-10-07 | | Method: | X-RAY DIFFRACTION (2.02 Å) | | Cite: | Investigation of the high-spin S 2 states in photosystem II using Mn X-ray absorption spectroscopy with insights from XFEL crystallography.
Biochim Biophys Acta Bioenerg, 1868, 2026
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13CL
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13CO
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13CP
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13FA
 | | Room Temperature X-Ray Structure of SARS-CoV-2 Main Protease in Complex with noncovalent inhibitor KB-0-2 | | Descriptor: | 3C-like proteinase nsp5, 6-[4-(2-amino-4,5-dichlorophenyl)piperazine-1-carbonyl]pyrimidine-2,4(1H,3H)-dione, SODIUM ION | | Authors: | Bhandari, D, Kovalevsky, A. | | Deposit date: | 2026-05-04 | | Release date: | 2026-09-09 | | Last modified: | 2026-10-07 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Noncovalent SARS-CoV-2 main protease inhibitors targeting the catalytic dyad and primed substrate binding subsites.
Rsc Med Chem, 17, 2026
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13HO
 | | Joint X-ray/neutron structure of deuterated SARS-CoV-2 main protease (MPro) in complex with noncovalent inhibitor KB-5 | | Descriptor: | 3C-like proteinase nsp5, N-{4,5-dichloro-2-[4-(5-fluoro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carbonyl)piperazin-1-yl]phenyl}cyclopropanecarboxamide, SODIUM ION | | Authors: | Bhandari, D, Kovalevsky, A. | | Deposit date: | 2026-05-06 | | Release date: | 2026-09-09 | | Last modified: | 2026-10-07 | | Method: | NEUTRON DIFFRACTION (1.9 Å), X-RAY DIFFRACTION | | Cite: | Noncovalent SARS-CoV-2 main protease inhibitors targeting the catalytic dyad and primed substrate binding subsites.
Rsc Med Chem, 17, 2026
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1MCZ
 | | BENZOYLFORMATE DECARBOXYLASE FROM PSEUDOMONAS PUTIDA COMPLEXED WITH AN INHIBITOR, R-MANDELATE | | Descriptor: | (R)-MANDELIC ACID, BENZOYLFORMATE DECARBOXYLASE, MAGNESIUM ION, ... | | Authors: | Polovnikova, E.S, Bera, A.K, Hasson, M.S. | | Deposit date: | 2002-08-06 | | Release date: | 2003-02-25 | | Last modified: | 2026-10-07 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural and kinetic analysis of catalysis by a thiamin diphosphate-dependent enzyme, benzoylformate decarboxylase.
Biochemistry, 42, 2003
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