9DB6
 
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9DHK
 | | RMI1-RMI2 bound to cyclic peptide L3 | | Descriptor: | L3 peptide, RecQ-mediated genome instability protein 1, RecQ-mediated genome instability protein 2 | | Authors: | Bythell-Douglas, R, Lau, Y, Alcock, L.J, Patel, K, Gao, T, Deshpande, C. | | Deposit date: | 2024-09-03 | | Release date: | 2025-07-02 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Potent Cyclic Peptide Inhibitors Disrupt the FANCM-RMI Interaction.
J.Med.Chem., 2025
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9DI4
 | | RMI1-RMI2 bound to cyclic peptide L4 | | Descriptor: | L4 cyclic peptide, RecQ-mediated genome instability protein 1, RecQ-mediated genome instability protein 2, ... | | Authors: | Bythell-Douglas, R, Lau, Y.H, Alcock, L.J, Gao, T, Deshpande, C, Patel, K. | | Deposit date: | 2024-09-05 | | Release date: | 2025-07-02 | | Method: | X-RAY DIFFRACTION (2.696 Å) | | Cite: | Potent Cyclic Peptide Inhibitors Disrupt the FANCM-RMI Interaction.
J.Med.Chem., 2025
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9E8Z
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9E90
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9E91
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9EJK
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9EJL
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9EJM
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9F5W
 | | Human condensin II - M18BP1 complex | | Descriptor: | Condensin-2 complex subunit D3, Condensin-2 complex subunit G2, Condensin-2 complex subunit H2, ... | | Authors: | Borsellini, A, Vannini, A. | | Deposit date: | 2024-04-30 | | Release date: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (7.5 Å) | | Cite: | Condensin II activation by M18BP1
To Be Published
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9FAJ
 | | CryoEM structure of human full-length alpha1beta3gamma2 GABA(A) receptor in complex with GARLH4, the TMD of Neuroligin2, GABA and Megabody38, in a desensitised state (StateD1) | | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, ... | | Authors: | Kasaragod, V.B, Aricescu, A.R. | | Deposit date: | 2024-05-10 | | Release date: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | CryoEM structure of human full-length alpha1beta3gamma2 GABA(A) receptor in complex with GARLH4, the TMD of Neuroligin2, GABA and Megabody38, in a desensitised state (StateD1)
To Be Published
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9FAK
 | | CryoEM structure of human full-length alpha1beta3gamma2 GABA(A) receptor in complex with GARLH4, the TMD of Neuroligin2, GABA and Megabody38 in a desensitised state (StateD2) | | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, ... | | Authors: | Kasaragod, V.B, Aricescu, A.R. | | Deposit date: | 2024-05-10 | | Release date: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | CryoEM structure of human full-length alpha1beta3gamma2 GABA(A) receptor in complex with GARLH4, the TMD of Neuroligin2, GABA and Megabody38 in a desensitised state (StateD2)
To Be Published
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9FAM
 | | CryoEM structure of human full-length alpha1beta3gamma2 GABA(A)R in complex with GARLH4, the TMD of Neuroligin2, GABA and Megabody38 in a desensitised state (StateD3) | | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | | Authors: | Kasaragod, V.B, Aricescu, A.R. | | Deposit date: | 2024-05-10 | | Release date: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | CryoEM structure of human full-length alpha1beta3gamma2 GABA(A)R in complex with GARLH4, the TMD of Neuroligin2, GABA and Megabody in a desensitised state (StateD3)
To Be Published
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9FAN
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9FAP
 | | CryoEM structure of human full-length alpha1beta3gamma2 GABA(A)R in complex with GARLH4, the TMD of Neuroligin2 and Megabody38 in a closed state (StateC1) | | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Kasaragod, V.B, Aricescu, A.R. | | Deposit date: | 2024-05-10 | | Release date: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | CryoEM structure of human full-length alpha1beta3gamma2 GABA(A)R in complex with GARLH4, the TMD of Neuroligin2 and Megabody38 in a closed state (StateC1)
To Be Published
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9FAQ
 | | CryoEM structure of human full-length alpha1beta3gamma2 GABA(A)R in complex with GARLH4, the TMD of Neuroligin2 and Megabody38 in a closed state (StateC2) | | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Kasaragod, V.B, Aricescu, A.R. | | Deposit date: | 2024-05-10 | | Release date: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | CryoEM structure of human full-length alpha1beta3gamma2 GABA(A)R in complex with GARLH4, the TMD of Neuroligin2 and Megabody38 in a closed state (StateC2)
To Be Published
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9FAR
 | | CryoEM structure of gamma2 subunit of GABA(A)R in complex with GARLH4, the TMD of Neuroligin2 from a closed state, obtained by focused refinement | | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, CHLORIDE ION, CHOLESTEROL, ... | | Authors: | Kasaragod, V.B, Aricescu, A.R. | | Deposit date: | 2024-05-10 | | Release date: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | CryoEM structure of gamma2 subunit of GABA(A)R in complex with GARLH4, the TMD of Neuroligin2 from a closed state, obtained by focused refinement
To Be Published
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9FAT
 | | CryoEM structure of human full-length alpha1beta3gamma2 GABA(A)R in complex with GARLH4, the TMD of Neuroligin2, Megabody38 and pregnenolone sulfate | | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Kasaragod, V.B, Aricescu, A.R. | | Deposit date: | 2024-05-10 | | Release date: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | CryoEM structure of human full-length alpha1beta3gamma2 GABA(A)R in complex with GARLH4, the TMD of Neuroligin2, Megabody38 and pregnenolone sulfate
To Be Published
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9FAU
 | | CryoEM structure of human full-length beta3gamma2 GABA(A) receptor in complex with GARLH4, the TMD of Neuroligin2 and Megabody25, in a closed state (StateC1) | | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Kasaragod, V.B, Aricescu, A.R. | | Deposit date: | 2024-05-10 | | Release date: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | CryoEM structure of human full-length beta3gamma2 GABA(A) receptor in complex with GARLH4, the TMD of Neuroligin2 and Megabody25, in a closed state (StateC1)
To Be Published
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9FAV
 | | CryoEM structure of human full-length beta3gamma2 GABA(A) receptor in complex with GARLH4, the TMD of Neuroligin2 and Megabody25, in a closed state (StateC2) | | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Kasaragod, V.B, Aricescu, A.R. | | Deposit date: | 2024-05-10 | | Release date: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | CryoEM structure of human full-length beta3gamma2 GABA(A) receptor in complex with GARLH4, the TMD of Neuroligin2 and Megabody25, in a closed state (StateC2)
To Be Published
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9FAW
 | | CryoEM structure of human full-length beta3gamma2 GABA(A) receptor in complex with GARLH4, the TMD of Neuroligin2, HEPES and Megabody25, in a desensitised state | | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Kasaragod, V.B, Aricescu, A.R. | | Deposit date: | 2024-05-10 | | Release date: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | CryoEM structure of human full-length beta3gamma2 GABA(A) receptor in complex with GARLH4, the TMD of Neuroligin2, HEPES and Megabody25, in a desensitised state
To Be Published
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9FAX
 | | CryoEM structure of human full-length beta3gamma2 GABA(A) receptor in complex with Megabody25, doubly occupied GARLH4 and Neuroligin2 TMD, in a closed state | | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Kasaragod, V.B, Aricescu, A.R. | | Deposit date: | 2024-05-10 | | Release date: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | CryoEM structure of human full-length beta3gamma2 GABA(A) receptor in complex with Megabody25, doubly occupied GARLH4 and Neuroligin2 TMD, in a closed state
To Be Published
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9FEL
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9FQ7
 | | Perkinsus marinus Respiratory supercomplex CII2CIII2CIV2 in c1 sate | | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 2-(HEXADECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL HEXADECANOATE, ... | | Authors: | Wu, F, Amunts, A. | | Deposit date: | 2024-06-14 | | Release date: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (2.5 Å) | | Cite: | Perkinsus marinus Respiratory supercomplex CII2CIII2CIV2 in c1 sate
To Be Published
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9FQF
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