10HY
 
 | | Structure of CHK1 10-pt. mutant complex with macrocyclic LRRK2 inhibitor compound 1 ((11R)-8-chloro-3,11-dimethyl-2-(oxan-4-yl)-2,4,10,11,12,13-hexahydro-9,5-(azeno)pyrazolo[3,4-b][1,4,6,10]oxatriazacyclotridecine) | | 分子名称: | (11R)-8-chloro-3,11-dimethyl-2-(oxan-4-yl)-2,4,10,11,12,13-hexahydro-9,5-(azeno)pyrazolo[3,4-b][1,4,6,10]oxatriazacyclotridecine, Serine/threonine-protein kinase Chk1 | | 著者 | Palte, R.L, Yu, E.C, Zhou, H. | | 登録日 | 2026-01-21 | | 公開日 | 2026-04-08 | | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | | 主引用文献 | Discovery of Potent, Selective, CNS-Penetrant Macrocyclic LRRK2 Inhibitors for the Treatment of Parkinson's Disease.
J.Med.Chem., 2026
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10HZ
 | | Structure of CHK1 10-pt. mutant complex with macrocyclic LRRK2 inhibitor compound 7 ((10aS,13aS)-3-cyclobutyl-1-methyl-8-(trifluoromethyl)-3,4,10a,11,13a,14-hexahydro-10H,13H-9,5-(azeno)furo[3,4-k]pyrazolo[4,3-b][1,4,6,10]oxatriazacyclotridecine) | | 分子名称: | (10aS,13aS)-3-cyclobutyl-1-methyl-8-(trifluoromethyl)-3,4,10a,11,13a,14-hexahydro-10H,13H-9,5-(azeno)furo[3,4-k]pyrazolo[4,3-b][1,4,6,10]oxatriazacyclotridecine, Serine/threonine-protein kinase Chk1 | | 著者 | Palte, R.L, Yu, E.C, Zhou, H. | | 登録日 | 2026-01-21 | | 公開日 | 2026-04-08 | | 実験手法 | X-RAY DIFFRACTION (1.666 Å) | | 主引用文献 | Discovery of Potent, Selective, CNS-Penetrant Macrocyclic LRRK2 Inhibitors for the Treatment of Parkinson's Disease.
J.Med.Chem., 2026
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10IA
 | | Structure of CHK1 10-pt. mutant complex with macrocyclic LRRK2 inhibitor compound 12 ((10aS,13aS)-3-cyclopropyl-1-methyl-8-(trifluoromethyl)-3,4,10a,11,13a,14-hexahydro-10H,13H-9,5-(azeno)furo[3,4-k]pyrazolo[4,3-b][1,4,6,10]oxatriazacyclotridecine) | | 分子名称: | (10aS,13aS)-3-cyclopropyl-1-methyl-8-(trifluoromethyl)-3,4,10a,11,13a,14-hexahydro-10H,13H-9,5-(azeno)furo[3,4-k]pyrazolo[4,3-b][1,4,6,10]oxatriazacyclotridecine, Serine/threonine-protein kinase Chk1 | | 著者 | Palte, R.L, Yu, E.C, Zhou, H. | | 登録日 | 2026-01-21 | | 公開日 | 2026-04-08 | | 実験手法 | X-RAY DIFFRACTION (1.739 Å) | | 主引用文献 | Discovery of Potent, Selective, CNS-Penetrant Macrocyclic LRRK2 Inhibitors for the Treatment of Parkinson's Disease.
J.Med.Chem., 2026
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10NM
 | | CRYO-EM STRUCTURE OF THE A149T DIMER VARIANT OF SERINE HYDROXYMETHYLTRANSFERASE 8 FROM SOYBEAN CULTIVAR ESSEX IN COMPLEX WITH PLP | | 分子名称: | Serine hydroxymethyltransferase | | 著者 | Beamer, L.J, Samarakoon, V, Buckley, D.P, Owuocha, L.F, Durie, C.L, Mitchum, M.G. | | 登録日 | 2026-01-28 | | 公開日 | 2026-04-08 | | 実験手法 | ELECTRON MICROSCOPY (2.92 Å) | | 主引用文献 | CRYO-EM STRUCTURE OF THE A149T DIMER VARIANT OF SERINE HYDROXYMETHYLTRANSFERASE 8 FROM SOYBEAN CULTIVAR ESSEX IN COMPLEX WITH PLP
To Be Published
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11BP
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11BQ
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11DG
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11FV
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11GG
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11KC
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11MS
 | | Influenza A virus Hemagglutinin (A/Darwin/6/2021 H3N2) (C1 symmetry) determined using the SPT Labtech chameleon in the presence of 0.25x SurfACT | | 分子名称: | Hemagglutinin | | 著者 | Enos, S.E, Cook, B.D, Rahmani, H, Narehood, S.M, Li, Y, Kuschnerus, I.C, Redford, H.T, Dukakis, P, Ji, D, Bachochin, M.J, Grotjahn, D.A, Herzik, M.A. | | 登録日 | 2026-03-05 | | 公開日 | 2026-04-08 | | 実験手法 | ELECTRON MICROSCOPY (2.39 Å) | | 主引用文献 | A Surfactant Cocktail Overcomes Air-Water Interface Artifacts in Single-Particle CryoEM.
Biorxiv, 2026
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11MT
 | | Influenza A virus Hemagglutinin (A/Darwin/6/2021 H3N2) (C3 symmetry) determined using the SPT Labtech chameleon in the presence of 0.25x SurfACT | | 分子名称: | Hemagglutinin | | 著者 | Enos, S.E, Cook, B.D, Rahmani, H, Narehood, S.M, Li, Y, Kuschnerus, I.C, Redford, H.T, Dukakis, P, Ji, D, Bachochin, M.J, Grotjahn, D.A, Herzik, M.A. | | 登録日 | 2026-03-05 | | 公開日 | 2026-04-08 | | 実験手法 | ELECTRON MICROSCOPY (2.16 Å) | | 主引用文献 | A Surfactant Cocktail Overcomes Air-Water Interface Artifacts in Single-Particle CryoEM.
Biorxiv, 2026
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11MU
 | | Influenza A virus Hemagglutinin (A/Darwin/6/2021 H3N2) (C1 symmetry) determined using the SPT Labtech chameleon in the presence of 1x SurfACT | | 分子名称: | Hemagglutinin | | 著者 | Enos, S.E, Cook, B.D, Rahmani, H, Narehood, S.M, Li, Y, Kuschnerus, I.C, Redford, H.T, Dukakis, P, Ji, D, Bachochin, M.J, Grotjahn, D.A, Herzik, M.A. | | 登録日 | 2026-03-05 | | 公開日 | 2026-04-08 | | 実験手法 | ELECTRON MICROSCOPY (2.67 Å) | | 主引用文献 | A Surfactant Cocktail Overcomes Air-Water Interface Artifacts in Single-Particle CryoEM.
Biorxiv, 2026
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11MV
 | | Influenza A virus Hemagglutinin (A/Darwin/6/2021 H3N2) (C3 symmetry) determined using the SPT Labtech chameleon in the presence of 1x SurfACT | | 分子名称: | Hemagglutinin | | 著者 | Enos, S.E, Cook, B.D, Rahmani, H, Narehood, S.M, Li, Y, Kuschnerus, I.C, Redford, H.T, Dukakis, P, Ji, D, Bachochin, M.J, Grotjahn, D.A, Herzik, M.A. | | 登録日 | 2026-03-05 | | 公開日 | 2026-04-08 | | 実験手法 | ELECTRON MICROSCOPY (2.47 Å) | | 主引用文献 | A Surfactant Cocktail Overcomes Air-Water Interface Artifacts in Single-Particle CryoEM.
Biorxiv, 2026
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11MX
 | | Influenza A virus Hemagglutinin (A/California/04/2009 H1N1), E47K HA2 stabilizing mutation (C1 symmetry) determined using the SPT Labtech chameleon in the presence of 0.25x SurfACT | | 分子名称: | Hemagglutinin | | 著者 | Enos, S.E, Cook, B.D, Rahmani, H, Narehood, S.M, Li, Y, Kuschnerus, I.C, Redford, H.T, Dukakis, P, Ji, D, Bachochin, M.J, Grotjahn, D.A, Herzik, M.A. | | 登録日 | 2026-03-05 | | 公開日 | 2026-04-08 | | 実験手法 | ELECTRON MICROSCOPY (2.94 Å) | | 主引用文献 | A Surfactant Cocktail Overcomes Air-Water Interface Artifacts in Single-Particle CryoEM.
Biorxiv, 2026
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11MZ
 | | Influenza A virus Hemagglutinin (A/California/04/2009 H1N1), E47K HA2 stabilizing mutation (C3 symmetry) determined using the SPT Labtech chameleon in the presence of 0.25x SurfACT | | 分子名称: | Hemagglutinin | | 著者 | Enos, S.E, Cook, B.D, Rahmani, H, Narehood, S.M, Li, Y, Kuschnerus, I.C, Redford, H.T, Dukakis, P, Ji, D, Bachochin, M.J, Grotjahn, D.A, Herzik, M.A. | | 登録日 | 2026-03-05 | | 公開日 | 2026-04-08 | | 実験手法 | ELECTRON MICROSCOPY (2.64 Å) | | 主引用文献 | A Surfactant Cocktail Overcomes Air-Water Interface Artifacts in Single-Particle CryoEM.
Biorxiv, 2026
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11NA
 | | Azotobacter vinelandii MoFeP (C1 symmetry) determined using the SPT Labtech chameleon in the presence of 0x SurfACT | | 分子名称: | 3-HYDROXY-3-CARBOXY-ADIPIC ACID, FE (III) ION, FE(8)-S(7) CLUSTER, ... | | 著者 | Enos, S.E, Cook, B.D, Rahmani, H, Narehood, S.M, Li, Y, Kuschnerus, I.C, Redford, H.T, Dukakis, P, Ji, D, Bachochin, M.J, Grotjahn, D.A, Herzik, M.A. | | 登録日 | 2026-03-05 | | 公開日 | 2026-04-08 | | 実験手法 | ELECTRON MICROSCOPY (2.69 Å) | | 主引用文献 | A Surfactant Cocktail Overcomes Air-Water Interface Artifacts in Single-Particle CryoEM.
Biorxiv, 2026
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11NB
 | | Azotobacter vinelandii MoFeP (C2 symmetry) determined using the SPT Labtech chameleon in the presence of 0x SurfACT | | 分子名称: | 3-HYDROXY-3-CARBOXY-ADIPIC ACID, FE (III) ION, FE(8)-S(7) CLUSTER, ... | | 著者 | Enos, S.E, Cook, B.D, Rahmani, H, Narehood, S.M, Li, Y, Kuschnerus, I.C, Redford, H.T, Dukakis, P, Ji, D, Bachochin, M.J, Grotjahn, D.A, Herzik, M.A. | | 登録日 | 2026-03-05 | | 公開日 | 2026-04-08 | | 実験手法 | ELECTRON MICROSCOPY (2.46 Å) | | 主引用文献 | A Surfactant Cocktail Overcomes Air-Water Interface Artifacts in Single-Particle CryoEM.
Biorxiv, 2026
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11NC
 | | Azotobacter vinelandii MoFeP (C1 symmetry) determined using the SPT Labtech chameleon in the presence of 0.25x SurfACT | | 分子名称: | 3-HYDROXY-3-CARBOXY-ADIPIC ACID, FE (III) ION, FE(8)-S(7) CLUSTER, ... | | 著者 | Enos, S.E, Cook, B.D, Rahmani, H, Narehood, S.M, Li, Y, Kuschnerus, I.C, Redford, H.T, Dukakis, P, Ji, D, Bachochin, M.J, Grotjahn, D.A, Herzik, M.A. | | 登録日 | 2026-03-05 | | 公開日 | 2026-04-08 | | 実験手法 | ELECTRON MICROSCOPY (2.16 Å) | | 主引用文献 | A Surfactant Cocktail Overcomes Air-Water Interface Artifacts in Single-Particle CryoEM.
Biorxiv, 2026
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11ND
 | | Azotobacter vinelandii MoFeP (C2 symmetry) determined using the SPT Labtech chameleon in the presence of 0.25x SurfACT | | 分子名称: | 3-HYDROXY-3-CARBOXY-ADIPIC ACID, FE (III) ION, FE(8)-S(7) CLUSTER, ... | | 著者 | Enos, S.E, Cook, B.D, Rahmani, H, Narehood, S.M, Li, Y, Kuschnerus, I.C, Redford, H.T, Dukakis, P, Ji, D, Bachochin, M.J, Grotjahn, D.A, Herzik, M.A. | | 登録日 | 2026-03-05 | | 公開日 | 2026-04-08 | | 実験手法 | ELECTRON MICROSCOPY (2.06 Å) | | 主引用文献 | A Surfactant Cocktail Overcomes Air-Water Interface Artifacts in Single-Particle CryoEM.
Biorxiv, 2026
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11NE
 | | Azotobacter vinelandii MoFeP (C1 symmetry) determined using the SPT Labtech chameleon in the presence of 1x SurfACT | | 分子名称: | 3-HYDROXY-3-CARBOXY-ADIPIC ACID, FE (III) ION, FE(8)-S(7) CLUSTER, ... | | 著者 | Enos, S.E, Cook, B.D, Rahmani, H, Narehood, S.M, Li, Y, Kuschnerus, I.C, Redford, H.T, Dukakis, P, Ji, D, Bachochin, M.J, Grotjahn, D.A, Herzik, M.A. | | 登録日 | 2026-03-05 | | 公開日 | 2026-04-08 | | 実験手法 | ELECTRON MICROSCOPY (2.49 Å) | | 主引用文献 | A Surfactant Cocktail Overcomes Air-Water Interface Artifacts in Single-Particle CryoEM.
Biorxiv, 2026
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11NF
 | | Azotobacter vinelandii MoFeP (C2 symmetry) determined using the SPT Labtech chameleon in the presence of 1x SurfACT | | 分子名称: | 3-HYDROXY-3-CARBOXY-ADIPIC ACID, FE (III) ION, FE(8)-S(7) CLUSTER, ... | | 著者 | Enos, S.E, Cook, B.D, Rahmani, H, Narehood, S.M, Li, Y, Kuschnerus, I.C, Redford, H.T, Dukakis, P, Ji, D, Bachochin, M.J, Grotjahn, D.A, Herzik, M.A. | | 登録日 | 2026-03-05 | | 公開日 | 2026-04-08 | | 実験手法 | ELECTRON MICROSCOPY (2.34 Å) | | 主引用文献 | A Surfactant Cocktail Overcomes Air-Water Interface Artifacts in Single-Particle CryoEM.
Biorxiv, 2026
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11NH
 | | Rabbit muscle Aldolase (C1 symmetry) determined using the SPT Labtech chameleon in the presence of 0x SurfACT | | 分子名称: | Fructose-bisphosphate aldolase A | | 著者 | Enos, S.E, Cook, B.D, Rahmani, H, Narehood, S.M, Li, Y, Kuschnerus, I.C, Redford, H.T, Dukakis, P, Ji, D, Bachochin, M.J, Grotjahn, D.A, Herzik, M.A. | | 登録日 | 2026-03-05 | | 公開日 | 2026-04-08 | | 実験手法 | ELECTRON MICROSCOPY (2.42 Å) | | 主引用文献 | A Surfactant Cocktail Overcomes Air-Water Interface Artifacts in Single-Particle CryoEM.
Biorxiv, 2026
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11NI
 | | Rabbit muscle Aldolase (D2 symmetry) determined using the SPT Labtech chameleon in the presence of 0x SurfACT | | 分子名称: | Fructose-bisphosphate aldolase A | | 著者 | Enos, S.E, Cook, B.D, Rahmani, H, Narehood, S.M, Li, Y, Kuschnerus, I.C, Redford, H.T, Dukakis, P, Ji, D, Bachochin, M.J, Grotjahn, D.A, Herzik, M.A. | | 登録日 | 2026-03-05 | | 公開日 | 2026-04-08 | | 実験手法 | ELECTRON MICROSCOPY (2.27 Å) | | 主引用文献 | A Surfactant Cocktail Overcomes Air-Water Interface Artifacts in Single-Particle CryoEM.
Biorxiv, 2026
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11NJ
 | | Rabbit muscle Aldolase (C1 symmetry) determined using the SPT Labtech chameleon in the presence of 0.25x SurfACT | | 分子名称: | Fructose-bisphosphate aldolase A | | 著者 | Enos, S.E, Cook, B.D, Rahmani, H, Narehood, S.M, Li, Y, Kuschnerus, I.C, Redford, H.T, Dukakis, P, Ji, D, Bachochin, M.J, Grotjahn, D.A, Herzik, M.A. | | 登録日 | 2026-03-05 | | 公開日 | 2026-04-08 | | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | | 主引用文献 | A Surfactant Cocktail Overcomes Air-Water Interface Artifacts in Single-Particle CryoEM.
Biorxiv, 2026
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