7RQE
 
 | | Crystal structure of the Thermus thermophilus 70S ribosome in complex with protein Y, A-site deacylated tRNA analog CACCA, P-site MAI-tripeptidyl-tRNA analog ACCA-IAM, and chloramphenicol at 2.40A resolution | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 16S Ribosomal RNA, 23S Ribosomal RNA, ... | | Authors: | Syroegin, E.A, Flemmich, L, Klepacki, D, Vazquez-Laslop, N, Micura, R, Polikanov, Y.S. | | Deposit date: | 2021-08-06 | | Release date: | 2022-01-26 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural basis for the context-specific action of the classic peptidyl transferase inhibitor chloramphenicol.
Nat.Struct.Mol.Biol., 29, 2022
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7RR5
 | | Structure of ribosomal complex bound with Rbg1/Tma46 | | Descriptor: | 18S rRNA, 25S rRNA, 40S ribosomal protein S0, ... | | Authors: | Zeng, F, Li, X, Pires-Alves, M, Chen, X, Hawk, C.W, Jin, H. | | Deposit date: | 2021-08-09 | | Release date: | 2021-11-10 | | Method: | ELECTRON MICROSCOPY (3.23 Å) | | Cite: | Conserved heterodimeric GTPase Rbg1/Tma46 promotes efficient translation in eukaryotic cells.
Cell Rep, 37, 2021
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7RRO
 | | Structure of the 48-nm repeat doublet microtubule from bovine tracheal cilia | | Descriptor: | Armadillo repeat containing 4, Chromosome 3 C1orf194 homolog, Cilia and flagella associated protein 161, ... | | Authors: | Gui, M, Anderson, J.R, Botsch, J.J, Meleppattu, S, Singh, S.K, Zhang, Q, Brown, A. | | Deposit date: | 2021-08-10 | | Release date: | 2021-10-27 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | De novo identification of mammalian ciliary motility proteins using cryo-EM.
Cell, 184, 2021
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7RS5
 | | Cryo-EM structure of Kip3 (AMPPNP) bound to Taxol-Stabilized Microtubules | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Hernandez-Lopez, R.A, Leschziner, A.E, Arellano-Santoyo, H, Pellman, D, Stokasimov, E, Wang, R.Y.-R. | | Deposit date: | 2021-08-10 | | Release date: | 2022-08-17 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Multimodal tubulin binding by the yeast kinesin-8, Kip3, underlies its motility and depolymerization
Biorxiv, 2021
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7RS6
 | | Cryo-EM structure of Kip3 (AMPPNP) bound to GMPCPP-Stabilized Microtubules | | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | Authors: | Hernandez-Lopez, R.A, Leschziner, A.E, Arellano-Santoyo, H, Pellman, D, Stokasimov, E, Wang, R.Y.-R. | | Deposit date: | 2021-08-11 | | Release date: | 2022-08-17 | | Last modified: | 2024-02-28 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Multimodal tubulin binding by the yeast kinesin-8, Kip3, underlies its motility and depolymerization
Biorxiv, 2024
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7RSX
 | | HIV-1 gp120 complex with CJF-III-049-S | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ENVELOPE GLYCOPROTEIN GP120, N~1~-{(1R,2R,3S)-2-(carbamimidamidomethyl)-3-[(3S)-3,4-dihydroxybutyl]-5-[(methylamino)methyl]-2,3-dihydro-1H-inden-1-yl}-N~2~-(4-chloro-3-fluorophenyl)ethanediamide | | Authors: | Liang, S, Hendrickson, W.A. | | Deposit date: | 2021-08-12 | | Release date: | 2022-06-08 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Identification of gp120 Residue His105 as a Novel Target for HIV-1 Neutralization by Small-Molecule CD4-Mimics.
Acs Med.Chem.Lett., 12, 2021
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7RSY
 | | HIV-1 gp120 complex with CJF-III-049-R | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, HIV-1 gp120 Clade C1086, N~1~-{(1R,2R,3S)-2-(carbamimidamidomethyl)-3-[(3R)-3,4-dihydroxybutyl]-5-[(methylamino)methyl]-2,3-dihydro-1H-inden-1-yl}-N~2~-(4-chloro-3-fluorophenyl)ethanediamide | | Authors: | Liang, S, Hendrickson, W.A. | | Deposit date: | 2021-08-12 | | Release date: | 2022-06-08 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Identification of gp120 Residue His105 as a Novel Target for HIV-1 Neutralization by Small-Molecule CD4-Mimics.
Acs Med.Chem.Lett., 12, 2021
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7RSZ
 | | HIV-1 gp120 complex with CJF-II-204 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, HIV-1 gp120 Clade C1086, N~1~-{(1R,2R,3S)-2-(carbamimidamidomethyl)-3-[(3R)-3,4-dihydroxybutyl]-5-[(methylamino)methyl]-2,3-dihydro-1H-inden-1-yl}-N~2~-(4-chloro-3-fluorophenyl)ethanediamide, ... | | Authors: | Liang, S, Hendrickson, W.A. | | Deposit date: | 2021-08-12 | | Release date: | 2022-06-08 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.79 Å) | | Cite: | Identification of gp120 Residue His105 as a Novel Target for HIV-1 Neutralization by Small-Molecule CD4-Mimics.
Acs Med.Chem.Lett., 12, 2021
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7RTE
 | | X-ray structure of wild type RBPJ-L3MBTL3-DNA complex | | Descriptor: | 1,2-ETHANEDIOL, DNA (5'-D(*AP*AP*TP*CP*TP*TP*TP*CP*CP*CP*AP*CP*GP*GP*T)-3'), DNA (5'-D(*TP*TP*AP*CP*CP*GP*TP*GP*GP*GP*AP*AP*AP*GP*A)-3'), ... | | Authors: | Hall, D.P, Kovall, R.A, Yuan, Z. | | Deposit date: | 2021-08-13 | | Release date: | 2022-08-24 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.06 Å) | | Cite: | The structure, binding and function of a Notch transcription complex involving RBPJ and the epigenetic reader protein L3MBTL3.
Nucleic Acids Res., 50, 2022
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7RTI
 | | X-ray structure of RBPJ-L3MBTL3(dT62)-DNA complex | | Descriptor: | 1,2-ETHANEDIOL, DNA (5'-D(*AP*AP*TP*CP*TP*TP*TP*CP*CP*CP*AP*CP*GP*GP*T)-3'), DNA (5'-D(*TP*TP*AP*CP*CP*GP*TP*GP*GP*GP*AP*AP*AP*GP*A)-3'), ... | | Authors: | Hall, D.P, Kovall, R.A, Yuan, Z. | | Deposit date: | 2021-08-13 | | Release date: | 2022-08-24 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | The structure, binding and function of a Notch transcription complex involving RBPJ and the epigenetic reader protein L3MBTL3.
Nucleic Acids Res., 50, 2022
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7RWL
 | | Envelope-associated Adeno-associated virus serotype 2 | | Descriptor: | Capsid protein VP1 | | Authors: | Hull, J.A, Mietzsch, M, Chipman, P, Strugatsky, D, McKenna, R. | | Deposit date: | 2021-08-20 | | Release date: | 2021-10-20 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.14 Å) | | Cite: | Structural characterization of an envelope-associated adeno-associated virus type 2 capsid.
Virology, 565, 2021
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7RWT
 | | Adeno-associated virus type 2 | | Descriptor: | Capsid protein VP1 | | Authors: | Hull, J.A, Mietzsch, M, Chipman, P, Strugatsky, D, McKenna, R. | | Deposit date: | 2021-08-20 | | Release date: | 2021-10-20 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (2.43 Å) | | Cite: | Structural characterization of an envelope-associated adeno-associated virus type 2 capsid.
Virology, 565, 2021
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7RXY
 | | Hen egg-white lysozyme with ionic liquid ethylammonium nitrate 5 mol% | | Descriptor: | Lysozyme C, NITRATE ION | | Authors: | Han, Q, Darmanin, C, Smith, K, Drummond, C, Greaves, T. | | Deposit date: | 2021-08-24 | | Release date: | 2023-03-01 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Probing ion-binding at a protein interface: Modulation of protein properties by ionic liquids.
J Colloid Interface Sci, 650, 2023
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7RY5
 | | Cellular Retinoic Acid Binding Protein II with Bound Inhibitor 4-[6-({4-[(fluorosulfonyl)oxy]phenyl}ethynyl)-4,4-dimethyl-3,4-dihydroquinolin-1(2H)-yl]-4-oxobutanoic acid | | Descriptor: | 4-[6-({4-[(fluorosulfonyl)oxy]phenyl}ethynyl)-4,4-dimethyl-3,4-dihydroquinolin-1(2H)-yl]-4-oxobutanoic acid, Cellular retinoic acid-binding protein 2 | | Authors: | Kimmel, B.R, Mrksich, M. | | Deposit date: | 2021-08-24 | | Release date: | 2021-12-15 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Development of an Enzyme-Inhibitor Reaction Using Cellular Retinoic Acid Binding Protein II for One-Pot Megamolecule Assembly.
Chemistry, 27, 2021
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7RYD
 | | Hen egg-white lysozyme with ionic liquid butylammonium nitrate 1 mol% | | Descriptor: | Lysozyme C, NITRATE ION | | Authors: | Han, Q, Darmanin, C, Smith, K, Drummond, C, Greaves, T. | | Deposit date: | 2021-08-25 | | Release date: | 2023-03-01 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.18 Å) | | Cite: | Probing ion-binding at a protein interface: Modulation of protein properties by ionic liquids.
J Colloid Interface Sci, 650, 2023
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7RYF
 | | A. baumannii Ribosome-TP-6076 complex: P-site tRNA 70S | | Descriptor: | (4S,4aS,5aR,12aS)-4-(diethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-8-[(2S)-pyrrolidin-2-yl]-7-(trifluoromethyl)-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide, 16S Ribosomal RNA, 23S ribosomal RNA, ... | | Authors: | Morgan, C.E, Yu, E.W. | | Deposit date: | 2021-08-25 | | Release date: | 2022-02-02 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (2.65 Å) | | Cite: | An Analysis of the Novel Fluorocycline TP-6076 Bound to Both the Ribosome and Multidrug Efflux Pump AdeJ from Acinetobacter baumannii.
Mbio, 13, 2022
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7RYG
 | | A. baumannii Ribosome-TP-6076 complex: E-site tRNA 70S | | Descriptor: | (4S,4aS,5aR,12aS)-4-(diethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-8-[(2S)-pyrrolidin-2-yl]-7-(trifluoromethyl)-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide, 16S Ribosomal RNA, 23S ribosomal RNA, ... | | Authors: | Morgan, C.E, Yu, E.W. | | Deposit date: | 2021-08-25 | | Release date: | 2022-02-02 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (2.38 Å) | | Cite: | An Analysis of the Novel Fluorocycline TP-6076 Bound to Both the Ribosome and Multidrug Efflux Pump AdeJ from Acinetobacter baumannii.
Mbio, 13, 2022
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7RYH
 | | A. baumannii Ribosome-TP-6076 complex: Empty 70S | | Descriptor: | (4S,4aS,5aR,12aS)-4-(diethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-8-[(2S)-pyrrolidin-2-yl]-7-(trifluoromethyl)-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide, 16S Ribosomal RNA, 23S ribosomal RNA, ... | | Authors: | Morgan, C.E, Yu, E.W. | | Deposit date: | 2021-08-25 | | Release date: | 2022-02-02 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (2.43 Å) | | Cite: | An Analysis of the Novel Fluorocycline TP-6076 Bound to Both the Ribosome and Multidrug Efflux Pump AdeJ from Acinetobacter baumannii.
Mbio, 13, 2022
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7RYJ
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7RYK
 | | Hen egg-white lysozyme with ionic liquid ethanolammonium nitrate 1 mol% | | Descriptor: | Lysozyme C, NITRATE ION | | Authors: | Han, Q, Darmanin, C, Smith, K, Drummond, C, Greaves, T. | | Deposit date: | 2021-08-25 | | Release date: | 2023-03-01 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.76 Å) | | Cite: | Probing ion-binding at a protein interface: Modulation of protein properties by ionic liquids.
J Colloid Interface Sci, 650, 2023
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7RZ0
 | | Hen egg-white lysozyme with ionic liquid ethanolammonium formate 6.7 mol% | | Descriptor: | ETHANOLAMINE, FORMIC ACID, Lysozyme C | | Authors: | Han, Q, Darmanin, C, Drummond, C, Greaves, T. | | Deposit date: | 2021-08-27 | | Release date: | 2023-03-01 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.38 Å) | | Cite: | Probing ion-binding at a protein interface: Modulation of protein properties by ionic liquids.
J Colloid Interface Sci, 650, 2023
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7RZ2
 | | Hen egg-white lysozyme with ionic liquid ethanolammonium formate 4 mol% | | Descriptor: | ETHANOLAMINE, FORMIC ACID, Lysozyme C | | Authors: | Han, Q, Darmanin, C, Drummond, C, Greaves, T. | | Deposit date: | 2021-08-27 | | Release date: | 2023-03-01 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.07 Å) | | Cite: | Probing ion-binding at a protein interface: Modulation of protein properties by ionic liquids.
J Colloid Interface Sci, 650, 2023
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7S0P
 | | Crystal structure of Porcine Factor VIII C2 Domain Bound to Phosphatidylserine | | Descriptor: | Coagulation factor VIII, PHOSPHOSERINE | | Authors: | Peters, S.C, Childers, K.C, Wo, S.W, Brison, C.M, Swanson, C.D, Spiegel, P.C. | | Deposit date: | 2021-08-30 | | Release date: | 2021-10-27 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Stable binding to phosphatidylserine-containing membranes requires conserved arginine residues in tandem C domains of blood coagulation factor VIII.
Front Mol Biosci, 9, 2022
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7S0S
 | | M. tuberculosis ribosomal RNA methyltransferase TlyA bound to M. smegmatis 50S ribosomal subunit | | Descriptor: | 16S/23S rRNA (Cytidine-2'-O)-methyltransferase TlyA, 23S rRNA, 50S ribosomal protein L10, ... | | Authors: | Laughlin, Z.T, Dunham, C.M, Conn, G.L. | | Deposit date: | 2021-08-31 | | Release date: | 2022-03-30 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (3.05 Å) | | Cite: | 50S subunit recognition and modification by the Mycobacterium tuberculosis ribosomal RNA methyltransferase TlyA.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7S1G
 | | wild-type Escherichia coli stalled ribosome with antibiotic linezolid | | Descriptor: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | | Authors: | Young, I.D, Stojkovic, V, Tsai, K, Lee, D.J, Fraser, J.S, Galonic Fujimori, D. | | Deposit date: | 2021-09-02 | | Release date: | 2021-11-17 | | Last modified: | 2023-11-15 | | Method: | ELECTRON MICROSCOPY (2.48 Å) | | Cite: | Structural basis for context-specific inhibition of translation by oxazolidinone antibiotics.
Nat.Struct.Mol.Biol., 29, 2022
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