7RSY

HIV-1 gp120 complex with CJF-III-049-R

This is a non-PDB format compatible entry.

Summary for 7RSY

• Entry DOI: 10.2210/pdb7rsy/pdb
• Descriptor: HIV-1 gp120 Clade C1086, 2-acetamido-2-deoxy-beta-D-glucopyranose, N~1~-{(1R,2R,3S)-2-(carbamimidamidomethyl)-3-[(3R)-3,4-dihydroxybutyl]-5-[(methylamino)methyl]-2,3-dihydro-1H-inden-1-yl}-N~2~-(4-chloro-3-fluorophenyl)ethanediamide, ... (4 entities in total)
• Functional Keywords: hiv-1 gp120, inhibitor, viral protein
• Biological source: Human immunodeficiency virus 1
• Total number of polymer chains: 4
• Total formula weight: 168926.16

Authors

Liang, S.,Hendrickson, W.A. (deposition date: 2021-08-12, release date: 2022-06-08, Last modification date: 2023-10-18)

• Primary citation: Fritschi, C.J.,Liang, S.,Mohammadi, M.,Anang, S.,Moraca, F.,Chen, J.,Madani, N.,Sodroski, J.G.,Abrams, C.F.,Hendrickson, W.A.,Smith 3rd, A.B.; Identification of gp120 Residue His105 as a Novel Target for HIV-1 Neutralization by Small-Molecule CD4-Mimics.; Acs Med.Chem.Lett., 12:1824-1831, 2021; PubMed: 34795873; DOI: 10.1021/acsmedchemlett.1c00437

Experimental method

X-RAY DIFFRACTION (2.7 Å)