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7N85
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BU of 7n85 by Molmil
Inner ring spoke from the isolated yeast NPC
Descriptor: Nucleoporin ASM4, Nucleoporin NIC96, Nucleoporin NSP1, ...
Authors:Akey, C.W, Rout, M.P, Ouch, C, Echevarria, I, Fernandez-Martinez, J, Nudelman, I.
Deposit date:2021-06-13
Release date:2022-01-26
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (7.6 Å)
Cite:Comprehensive structure and functional adaptations of the yeast nuclear pore complex.
Cell, 185, 2022
7N8B
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BU of 7n8b by Molmil
Cycloheximide bound vacant 80S structure isolated from cbf5-D95A
Descriptor: 18S RIBOSOMAL RNA, 25S, 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione, ...
Authors:Rai, J, Zhao, Y, Li, H.
Deposit date:2021-06-14
Release date:2022-05-11
Last modified:2025-05-21
Method:ELECTRON MICROSCOPY (3.05 Å)
Cite:CryoEM structures of pseudouridine-free ribosome suggest impacts of chemical modifications on ribosome conformations.
Structure, 30, 2022
7N9F
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BU of 7n9f by Molmil
Structure of the in situ yeast NPC
Descriptor: Dynein light chain 1, cytoplasmic, Nucleoporin 145c, ...
Authors:Villa, E, Singh, D, Ludtke, S.J, Akey, C.W, Rout, M.P, Echeverria, I, Suslov, S.
Deposit date:2021-06-17
Release date:2022-01-26
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (37 Å)
Cite:Comprehensive structure and functional adaptations of the yeast nuclear pore complex.
Cell, 185, 2022
7N9X
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BU of 7n9x by Molmil
CA-targeting nanobody is a tool for studying HIV-1 capsid lattice interactions
Descriptor: Capsid protein, Nanobody, Peptidyl-prolyl cis-trans isomerase A
Authors:Gerber, E.E, Digianantonio, K.M, Tripler, T.N, Smaga, S.S, Summers, B.J, Xiong, Y.
Deposit date:2021-06-18
Release date:2022-06-22
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (3.511 Å)
Cite:CA-targeting nanobody is a tool for studying HIV-1 capsid lattice interactions
To Be Published
7NA6
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BU of 7na6 by Molmil
Cryo-EM structure of AAV True Type
Descriptor: Capsid protein VP1
Authors:Bennett, A.D, McKenna, R.
Deposit date:2021-06-19
Release date:2021-09-29
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.35 Å)
Cite:Comparative structural, biophysical, and receptor binding study of true type and wild type AAV2.
J.Struct.Biol., 213, 2021
7NAC
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BU of 7nac by Molmil
State E2 nucleolar 60S ribosomal biogenesis intermediate - Composite model
Descriptor: 25S rRNA, 25S rRNA (cytosine(2870)-C(5))-methyltransferase, 27S pre-rRNA (guanosine(2922)-2'-O)-methyltransferase, ...
Authors:Cruz, V.E, Sekulski, K, Peddada, N, Erzberger, J.P.
Deposit date:2021-06-21
Release date:2022-11-09
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3.04 Å)
Cite:Sequence-specific remodeling of a topologically complex RNP substrate by Spb4.
Nat.Struct.Mol.Biol., 29, 2022
7NB1
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BU of 7nb1 by Molmil
Crystal structure of human choline alpha in complex with an inhibitor
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 4-(6-aminopurin-9-yl)-~{N}-[4-(trifluoromethylsulfonyl)phenyl]cyclohexane-1-carboxamide, Choline kinase alpha
Authors:Casale, E, Fasolini, M.
Deposit date:2021-01-25
Release date:2021-10-13
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Identification of unprecedented ATP-competitive choline kinase inhibitors.
Bioorg.Med.Chem.Lett., 51, 2021
7NB2
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BU of 7nb2 by Molmil
Crystal structure of human choline alpha in complex with an inhibitor
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 4-(6-azanyl-2-chloranyl-purin-9-yl)-~{N}-(4-methyl-1,3-thiazol-2-yl)cyclohexane-1-carboxamide, Choline kinase alpha, ...
Authors:Casale, E, Fasolini, M.
Deposit date:2021-01-25
Release date:2021-10-13
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Identification of unprecedented ATP-competitive choline kinase inhibitors.
Bioorg.Med.Chem.Lett., 51, 2021
7NB3
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BU of 7nb3 by Molmil
Crystal structure of human choline alpha in complex with an inhibitor
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 4-(6-azanyl-2-pyridin-4-yl-purin-9-yl)-~{N}-(3-methoxyphenyl)cyclohexane-1-carboxamide, Choline kinase alpha, ...
Authors:Casale, E, Fasolini, M.
Deposit date:2021-01-25
Release date:2021-10-13
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:Identification of unprecedented ATP-competitive choline kinase inhibitors.
Bioorg.Med.Chem.Lett., 51, 2021
7NBC
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BU of 7nbc by Molmil
Crystal structure of human serine racemase in complex with DSiP fragment Z2856434779, XChem fragment screen.
Descriptor: 1,2-ETHANEDIOL, 2-(2-METHOXYETHOXY)ETHANOL, CALCIUM ION, ...
Authors:Koulouris, C.R, Roe, S.M.
Deposit date:2021-01-26
Release date:2021-03-03
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemase.
Commun Biol, 5, 2022
7NBD
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BU of 7nbd by Molmil
Crystal structure of human serine racemase in complex with DSiP fragment Z235449082, XChem fragment screen.
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, GLYCEROL, ...
Authors:Koulouris, C.R, Roe, S.M.
Deposit date:2021-01-26
Release date:2021-03-03
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.865 Å)
Cite:Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemase.
Commun Biol, 5, 2022
7NBF
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BU of 7nbf by Molmil
Crystal structure of human serine racemase in complex with DSiP fragment Z126932614, XChem fragment screen.
Descriptor: 1,2-ETHANEDIOL, 2-[(methylsulfonyl)methyl]-1H-benzimidazole, CALCIUM ION, ...
Authors:Koulouris, C.R, Roe, S.M.
Deposit date:2021-01-26
Release date:2021-03-03
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemase.
Commun Biol, 5, 2022
7NBG
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BU of 7nbg by Molmil
Crystal structure of human serine racemase in complex with DSiP fragment Z52314092, XChem fragment screen.
Descriptor: 1,2-ETHANEDIOL, 2-(2-METHOXYETHOXY)ETHANOL, CALCIUM ION, ...
Authors:Koulouris, C.R, Roe, S.M.
Deposit date:2021-01-26
Release date:2021-03-03
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemase.
Commun Biol, 5, 2022
7NBH
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BU of 7nbh by Molmil
Crystal structure of human serine racemase in complex with DSiP fragment Z26781964, XChem fragment screen.
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, CHLORIDE ION, ...
Authors:Koulouris, C.R, Roe, S.M.
Deposit date:2021-01-26
Release date:2021-03-03
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemase.
Commun Biol, 5, 2022
7NBR
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BU of 7nbr by Molmil
Crystal structure of SARS-CoV-2 main protease (Mpro) in complex with the HCV NS3/4A inhibitor boceprevir
Descriptor: 3C-like proteinase, CHLORIDE ION, boceprevir (bound form)
Authors:Zhang, L, Hilgenfeld, R.
Deposit date:2021-01-27
Release date:2021-03-03
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of SARS-CoV-2 main protease (Mpro) in complex with the HCV NS3/4A inhibitor boceprevir
To Be Published
7NBS
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BU of 7nbs by Molmil
Crystal structure of SARS-CoV-2 main protease (Mpro) in complex with the HCV NS3/4A inhibitor telaprevir
Descriptor: (1S,3aR,6aS)-2-[(2S)-2-({(2S)-2-cyclohexyl-2-[(pyrazin-2-ylcarbonyl)amino]acetyl}amino)-3,3-dimethylbutanoyl]-N-[(2R,3S)-1-(cyclopropylamino)-2-hydroxy-1-oxohexan-3-yl]octahydrocyclopenta[c]pyrrole-1-carboxamide, 3C-like proteinase, CHLORIDE ION
Authors:Zhang, L, Hilgenfeld, R.
Deposit date:2021-01-27
Release date:2021-03-03
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of SARS-CoV-2 main protease (Mpro) in complex with the HCV NS3/4A inhibitor boceprevir
To Be Published
7NBT
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BU of 7nbt by Molmil
Crystal Structure of SARS-CoV-2 main protease (Nsp5) in complex with compound 21
Descriptor: 2-(benzotriazol-1-yl)-1-[(4~{S})-4-methyl-6,7-dihydro-4~{H}-thieno[3,2-c]pyridin-5-yl]ethanone, 3C-like proteinase nsp5, DIMETHYL SULFOXIDE
Authors:Talibov, V.O.
Deposit date:2021-01-27
Release date:2022-02-23
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses.
J.Am.Chem.Soc., 144, 2022
7NBU
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BU of 7nbu by Molmil
Structure of the HigB1 toxin mutant K95A from Mycobacterium tuberculosis (Rv1955) and its target, the cspA mRNA, on the E. coli Ribosome.
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Giudice, E, Mansour, M, Chat, S, D'Urso, G, Gillet, R, Genevaux, P.
Deposit date:2021-01-27
Release date:2022-03-02
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (3.11 Å)
Cite:Substrate recognition and cryo-EM structure of the ribosome-bound TAC toxin of Mycobacterium tuberculosis.
Nat Commun, 13, 2022
7NCX
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BU of 7ncx by Molmil
Crystal structure of GH30 (double mutant EE) from Thermothelomyces thermophila.
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, DI(HYDROXYETHYL)ETHER, ...
Authors:Dimarogona, M, Nikolaivits, E, Topakas, E, Weiss, M, Feiler, C.G.
Deposit date:2021-01-29
Release date:2021-09-08
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.36 Å)
Cite:Unique features of the bifunctional GH30 from Thermothelomyces thermophila revealed by structural and mutational studies
Carbohydrate Polymers, 273, 2021
7NDQ
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BU of 7ndq by Molmil
Gag:02 TCR in complex with HLA-E.
Descriptor: Beta-2-microglobulin, Gag6V, HLA class I histocompatibility antigen, ...
Authors:Pengelly, R.J, Robinson, R.A.
Deposit date:2021-02-02
Release date:2022-01-26
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.551 Å)
Cite:Structure-guided stabilization of pathogen-derived peptide-HLA-E complexes using non-natural amino acids conserves native TCR recognition.
Eur.J.Immunol., 52, 2022
7NDT
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BU of 7ndt by Molmil
UL40:01 TCR in complex with HLA-E with a non-natural amino acid
Descriptor: Beta-2-microglobulin, HLA class I histocompatibility antigen, alpha chain E, ...
Authors:Pengelly, R.J, Robinson, R.A.
Deposit date:2021-02-02
Release date:2022-01-26
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.999 Å)
Cite:Structure-guided stabilization of pathogen-derived peptide-HLA-E complexes using non-natural amino acids conserves native TCR recognition.
Eur.J.Immunol., 52, 2022
7NDU
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BU of 7ndu by Molmil
Gag:02 TCR in complex with HLA-E featuring a non-natural amino acid
Descriptor: Beta-2-microglobulin, Gag6V(276-284 H4C), HLA class I histocompatibility antigen, ...
Authors:Pengelly, R.J, Robinson, R.A.
Deposit date:2021-02-02
Release date:2022-01-26
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure-guided stabilization of pathogen-derived peptide-HLA-E complexes using non-natural amino acids conserves native TCR recognition.
Eur.J.Immunol., 52, 2022
7NE9
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BU of 7ne9 by Molmil
A single sensor controls large variations in zinc quotas in a marine cyanobacterium
Descriptor: ACETATE ION, Ferric uptake regulator family, ZINC ION
Authors:Fulop, V.
Deposit date:2021-02-03
Release date:2022-03-02
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A single sensor controls large variations in zinc quotas in a marine cyanobacterium.
Nat.Chem.Biol., 18, 2022
7NEO
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BU of 7neo by Molmil
Crystal Structure of SARS-CoV-2 main protease (Nsp5) in complex with compound 15
Descriptor: 2-cyclobutyl-7-(5-fluoropyridin-3-yl)-5,7-diazaspiro[3.4]octane-6,8-dione, 3C-like proteinase nsp5, DIMETHYL SULFOXIDE
Authors:Talibov, V.O.
Deposit date:2021-02-04
Release date:2022-02-23
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Ultralarge Virtual Screening Identifies SARS-CoV-2 Main Protease Inhibitors with Broad-Spectrum Activity against Coronaviruses.
J.Am.Chem.Soc., 144, 2022
7NFV
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BU of 7nfv by Molmil
Structure of SARS-CoV-2 Papain-like protease PLpro
Descriptor: CHLORIDE ION, GLYCEROL, PHOSPHATE ION, ...
Authors:Srinivasan, V, Gunther, S, Reinke, P, Werner, N, Falke, S, Brognaro, H, Ullah, N, Andaleeb, H, Perbandt, M, Alves Franca, B, Schwinzer, M, Wang, M, Sprenger, J, Lieske, J, Ginn, H, Lane, T.J, Yefanov, O, Gelisio, L, Koua, F, Saouane, S, Tolstikova, A, Groessler, M, Fleckenstein, H, Ewert, W, Trost, F, Lorenzen, K, Schubert, R, Han, H, Schmidt, C, Brings, L, Ehrt, C, Rarey, M, Galchenkova, M, Gevorkov, Y, Li, C, Perk, A, Awel, S, Hinrichs, W, Meents, A, Betzel, C.
Deposit date:2021-02-07
Release date:2021-02-24
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Antiviral activity of natural phenolic compounds in complex at an allosteric site of SARS-CoV-2 papain-like protease.
Commun Biol, 5, 2022

238582

数据于2025-07-09公开中

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