6TJK
 
 | | Crystal Structure of Recombinant GBA in Complex with Bis-Tris Propane. | | 分子名称: | 1,2-ETHANEDIOL, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Rowland, R.J, Davies, G.J. | | 登録日 | 2019-11-26 | | 公開日 | 2020-06-10 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | | 主引用文献 | A baculoviral system for the production of human beta-glucocerebrosidase enables atomic resolution analysis.
Acta Crystallogr D Struct Biol, 76, 2020
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6TJQ
 | | Crystal Structure of Recombinant GBA in Complex with 2-Deoxy-2-fluoro-beta-D-glucopyranoside | | 分子名称: | (2~{R},3~{S},4~{S},5~{S})-5-fluoranyl-2-(hydroxymethyl)oxane-3,4-diol, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Rowland, R.J, Davies, G.J. | | 登録日 | 2019-11-26 | | 公開日 | 2020-06-10 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (1.41 Å) | | 主引用文献 | A baculoviral system for the production of human beta-glucocerebrosidase enables atomic resolution analysis.
Acta Crystallogr D Struct Biol, 76, 2020
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6TJS
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6TJU
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6TK8
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6TKA
 | | Crystal structure of human O-GlcNAc transferase bound to substrate 7 and a peptide from HCF-1 pro-repeat 2 (11-26) | | 分子名称: | 3-[2,2-bis(fluoranyl)-10,12-dimethyl-1,3-diaza-2$l^{4}-boratricyclo[7.3.0.0^{3,7}]dodeca-4,6,9,11-tetraen-4-yl]-~{N}-ethyl-propanamide, HCF-1 pro-repeat 2 (11-26), UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, ... | | 著者 | Meek, R.W, Davies, G.J. | | 登録日 | 2019-11-28 | | 公開日 | 2020-03-04 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | | 主引用文献 | A Direct Fluorescent Activity Assay for Glycosyltransferases Enables Convenient High-Throughput Screening: Application to O-GlcNAc Transferase.
Angew.Chem.Int.Ed.Engl., 59, 2020
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6TKB
 | | ChiLob 7/4 H2 HC-C224S F(ab')2 | | 分子名称: | Chilob 7/4 H2 heavy chain C224S, Chilob 7/4 H2 kappa chain | | 著者 | Orr, C.M, Fisher, H, Tews, I. | | 登録日 | 2019-11-28 | | 公開日 | 2021-06-09 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Hinge disulfides in human IgG2 CD40 antibodies modulate receptor signaling by regulation of conformation and flexibility.
Sci Immunol, 7, 2022
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6TKC
 | | ChiLob 7/4 H2 HC-C225S F(ab')2 | | 分子名称: | Chilob 7/4 H2 heavy chain C225S, Chilob 7/4 H2 kappa chain | | 著者 | Orr, C.M, Fisher, H, Tews, I. | | 登録日 | 2019-11-28 | | 公開日 | 2021-06-09 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Hinge disulfides in human IgG2 CD40 antibodies modulate receptor signaling by regulation of conformation and flexibility.
Sci Immunol, 7, 2022
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6TKD
 | | ChiLob 7/4 H2 HC-C228S F(ab')2 | | 分子名称: | Chilob 7/4 H2 heavy chain C228S, Chilob 7/4 H2 kappa chain | | 著者 | Orr, C.M, Fisher, H, Tews, I. | | 登録日 | 2019-11-28 | | 公開日 | 2021-06-09 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Hinge disulfides in human IgG2 CD40 antibodies modulate receptor signaling by regulation of conformation and flexibility.
Sci Immunol, 7, 2022
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6TKE
 | | ChiLob 7/4 H2 HC-C224S Kappa LC-C214S F(ab')2 | | 分子名称: | ChiLob 7/4 H2 heavy chain C224S, ChiLob 7/4 H2 kappa chain C214S | | 著者 | Orr, C.M, Fisher, H, Tews, I. | | 登録日 | 2019-11-28 | | 公開日 | 2021-06-09 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Hinge disulfides in human IgG2 CD40 antibodies modulate receptor signaling by regulation of conformation and flexibility.
Sci Immunol, 7, 2022
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6TKF
 | | ChiLob 7/4 H2 HC-C225S KappaLC-C214S F(ab')2 | | 分子名称: | ChiLob 7/4 H2 Heavy chain C225S, ChiLob 7/4 H2 Kappa light chain C214S | | 著者 | Orr, C.M, Fisher, H, Tews, I. | | 登録日 | 2019-11-28 | | 公開日 | 2021-06-09 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | | 主引用文献 | Hinge disulfides in human IgG2 CD40 antibodies modulate receptor signaling by regulation of conformation and flexibility.
Sci Immunol, 7, 2022
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6TKM
 | | Tankyrase 2 in complex with an inhibitor (OM-1800) | | 分子名称: | Tankyrase-2, ZINC ION, ~{N}-[3-[5-(5-ethoxypyridin-2-yl)-4-(2-fluorophenyl)-1,2,4-triazol-3-yl]cyclobutyl]-1,5-naphthyridine-4-carboxamide | | 著者 | Sowa, S.T, Lehtio, L. | | 登録日 | 2019-11-28 | | 公開日 | 2020-07-08 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Preclinical Lead Optimization of a 1,2,4-Triazole Based Tankyrase Inhibitor.
J.Med.Chem., 63, 2020
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6TKN
 | | Tankyrase 2 in complex with an inhibitor (OM-1000) | | 分子名称: | Tankyrase-2, ZINC ION, ~{N}-[3-[4-(2-chlorophenyl)-5-pyrimidin-4-yl-1,2,4-triazol-3-yl]-1-bicyclo[1.1.1]pentanyl]pyridine-2-carboxamide | | 著者 | Sowa, S.T, Lehtio, L. | | 登録日 | 2019-11-28 | | 公開日 | 2020-07-08 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Preclinical Lead Optimization of a 1,2,4-Triazole Based Tankyrase Inhibitor.
J.Med.Chem., 63, 2020
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6TKP
 | | Tankyrase 2 in complex with an inhibitor (OM-1900) | | 分子名称: | Tankyrase-2, ZINC ION, ~{N}-[3-[4-(2-chlorophenyl)-5-(5-ethoxypyridin-2-yl)-1,2,4-triazol-3-yl]cyclobutyl]-1,5-naphthyridine-4-carboxamide | | 著者 | Sowa, S.T, Lehtio, L. | | 登録日 | 2019-11-28 | | 公開日 | 2020-07-08 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Preclinical Lead Optimization of a 1,2,4-Triazole Based Tankyrase Inhibitor.
J.Med.Chem., 63, 2020
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6TKQ
 | | Tankyrase 2 in complex with an inhibitor (OM-2700) | | 分子名称: | Tankyrase-2, ZINC ION, ~{N}-[3-[5-(5-ethoxypyridin-2-yl)-4-phenyl-1,2,4-triazol-3-yl]cyclobutyl]-1,5-naphthyridine-4-carboxamide | | 著者 | Sowa, S.T, Lehtio, L. | | 登録日 | 2019-11-28 | | 公開日 | 2020-07-08 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Preclinical Lead Optimization of a 1,2,4-Triazole Based Tankyrase Inhibitor.
J.Med.Chem., 63, 2020
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6TKR
 | | Tankyrase 2 in complex with an inhibitor (OM-1704) | | 分子名称: | Tankyrase-2, ZINC ION, ~{N}-[3-[5-(5-ethoxypyridin-2-yl)-4-(2-fluorophenyl)-1,2,4-triazol-3-yl]cyclobutyl]-1,5-naphthyridine-2-carboxamide | | 著者 | Sowa, S.T, Lehtio, L. | | 登録日 | 2019-11-28 | | 公開日 | 2020-07-08 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Preclinical Lead Optimization of a 1,2,4-Triazole Based Tankyrase Inhibitor.
J.Med.Chem., 63, 2020
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6TKS
 | | Tankyrase 2 in complex with an inhibitor (OM-1720) | | 分子名称: | Tankyrase-2, ZINC ION, ~{N}-[3-[5-(5-ethoxypyridin-2-yl)-4-(2-fluorophenyl)-1,2,4-triazol-3-yl]cyclobutyl]-1,6-naphthyridine-2-carboxamide | | 著者 | Sowa, S.T, Lehtio, L. | | 登録日 | 2019-11-28 | | 公開日 | 2020-07-08 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Preclinical Lead Optimization of a 1,2,4-Triazole Based Tankyrase Inhibitor.
J.Med.Chem., 63, 2020
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6TKZ
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6TLU
 | | HUMAN CK2 KINASE ALPHA SUBUNIT IN COMPLEX WITH THE ATP-COMPETITIVE INHIBITOR 4,5-DIBROMOBENZOTRIAZOLE | | 分子名称: | 6,7-bis(bromanyl)-1~{H}-benzotriazole, Casein kinase II subunit alpha, SODIUM ION | | 著者 | Czapinska, H, Piasecka, A, Winiewska-Szajewska, M, Bochtler, M, Poznanski, J. | | 登録日 | 2019-12-03 | | 公開日 | 2020-12-16 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | | 主引用文献 | Halogen Atoms in the Protein-Ligand System. Structural and Thermodynamic Studies of the Binding of Bromobenzotriazoles by the Catalytic Subunit of Human Protein Kinase CK2.
J.Phys.Chem.B, 125, 2021
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6TM4
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6TMG
 | | Cryo-EM structure of Toxoplasma gondii mitochondrial ATP synthase dimer, membrane region model | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, ATPTG1, ... | | 著者 | Muhleip, A, Kock Flygaard, R, Amunts, A. | | 登録日 | 2019-12-04 | | 公開日 | 2020-12-16 | | 最終更新日 | 2025-04-09 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | ATP synthase hexamer assemblies shape cristae of Toxoplasma mitochondria.
Nat Commun, 12, 2021
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6TMJ
 | | Cryo-EM structure of Toxoplasma gondii mitochondrial ATP synthase dimer, rotor-stator model | | 分子名称: | ATP synthase subunit delta, ATP synthase subunit epsilon, ATP synthase subunit gamma, ... | | 著者 | Muhleip, A, Kock Flygaard, R, Amunts, A. | | 登録日 | 2019-12-04 | | 公開日 | 2020-12-16 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | ATP synthase hexamer assemblies shape cristae of Toxoplasma mitochondria.
Nat Commun, 12, 2021
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6TMK
 | | Cryo-EM structure of Toxoplasma gondii mitochondrial ATP synthase dimer, composite model | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, ADENOSINE-5'-DIPHOSPHATE, ... | | 著者 | Muhleip, A, Kock Flygaard, R, Amunts, A. | | 登録日 | 2019-12-04 | | 公開日 | 2020-12-16 | | 最終更新日 | 2025-04-09 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | ATP synthase hexamer assemblies shape cristae of Toxoplasma mitochondria.
Nat Commun, 12, 2021
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6TML
 | | Cryo-EM structure of Toxoplasma gondii mitochondrial ATP synthase hexamer, composite model | | 分子名称: | ATP synthase subunit alpha, ATP synthase subunit beta, ATP synthase subunit delta, ... | | 著者 | Muhleip, A, Kock Flygaard, R, Amunts, A. | | 登録日 | 2019-12-04 | | 公開日 | 2020-12-16 | | 最終更新日 | 2024-11-06 | | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | | 主引用文献 | ATP synthase hexamer assemblies shape cristae of Toxoplasma mitochondria.
Nat Commun, 12, 2021
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6TMM
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