6TKM

Tankyrase 2 in complex with an inhibitor (OM-1800)

This is a non-PDB format compatible entry.

Summary for 6TKM

• Entry DOI: 10.2210/pdb6tkm/pdb
• Descriptor: Tankyrase-2, ~{N}-[3-[5-(5-ethoxypyridin-2-yl)-4-(2-fluorophenyl)-1,2,4-triazol-3-yl]cyclobutyl]-1,5-naphthyridine-4-carboxamide, ZINC ION, ... (4 entities in total)
• Functional Keywords: inhibitor, complex, poly-adp-ribosylation, enzyme, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 55749.41

Authors

Sowa, S.T.,Lehtio, L. (deposition date: 2019-11-28, release date: 2020-07-08, Last modification date: 2024-01-24)

• Primary citation: Waaler, J.,Leenders, R.G.G.,Sowa, S.T.,Alam Brinch, S.,Lycke, M.,Nieczypor, P.,Aertssen, S.,Murthy, S.,Galera-Prat, A.,Damen, E.,Wegert, A.,Nazare, M.,Lehtio, L.,Krauss, S.; Preclinical Lead Optimization of a 1,2,4-Triazole Based Tankyrase Inhibitor.; J.Med.Chem., 63:6834-6846, 2020; PubMed: 32511917; DOI: 10.1021/acs.jmedchem.0c00208

Experimental method

X-RAY DIFFRACTION (2.7 Å)