8KEH
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8Y4C
| BA.2.86 S-trimer in complex with Nab XGv280 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, XGv280 Heavy chain, ... | Authors: | Zhu, Q, Liu, P. | Deposit date: | 2024-01-30 | Release date: | 2024-09-04 | Method: | ELECTRON MICROSCOPY (3.75 Å) | Cite: | Enhancing RBD exposure and S1 shedding by an extremely conserved SARS-CoV-2 NTD epitope. Signal Transduct Target Ther, 9, 2024
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8YLS
| Structure of SARS-CoV-2 Mpro in complex with its degrader | Descriptor: | (4-methoxyphenyl)methyl ~{N}-[(2~{S})-4-methyl-1-oxidanylidene-1-[[(2~{S})-1-oxidanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]pentan-2-yl]carbamate, 3C-like proteinase nsp5 | Authors: | Feng, Y, Li, W, Cheng, S.H, Li, X.B. | Deposit date: | 2024-03-06 | Release date: | 2024-09-04 | Last modified: | 2024-09-18 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | The Main Protease Degraders: Potent Broad-Spectrum Agents for Anti-Coronavirus Agents To Be Published
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8ZER
| Crystal structure of the complex of Wuhan SARS-CoV-2 RBD (319-541) with P2C5 nanobody | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody P2C5, Spike protein S1, ... | Authors: | Sluchanko, N.N, Varfolomeeva, L.A, Shcheblyakov, D.V, Logunov, D.Y, Gintsburg, A.L, Popov, V.O, Boyko, K.M. | Deposit date: | 2024-05-06 | Release date: | 2024-09-04 | Last modified: | 2024-09-18 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural Basis for Evasion of New SARS-CoV-2 Variants from the Potent Virus-Neutralizing Nanobody Targeting the S-Protein Receptor-Binding Domain. Biochemistry Mosc., 89, 2024
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8ZES
| Crystal structure of the Wuhan SARS-CoV-2 RBD (333-541) complexed with P2C5 nanobody | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody P2C5, ... | Authors: | Sluchanko, N.N, Varfolomeeva, L.A, Shcheblyakov, D.V, Logunov, D.Y, Gintsburg, A.L, Popov, V.O, Boyko, K.M. | Deposit date: | 2024-05-06 | Release date: | 2024-09-04 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | Structural Basis for Evasion of New SARS-CoV-2 Variants from the Potent Virus-Neutralizing Nanobody Targeting the S-Protein Receptor-Binding Domain. Biochemistry Mosc., 89, 2024
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9EO6
| SARS-CoV2 major protease in complex with a covalent inhibitor SLL11. | Descriptor: | 3C-like proteinase nsp5, Inhibitor SLL11, POTASSIUM ION | Authors: | Moche, M, Lennerstrand, J, Nyman, T, Strandback, E, Akaberi, D. | Deposit date: | 2024-03-14 | Release date: | 2024-09-04 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | Identification of novel and potent inhibitors of SARS-CoV-2 main protease from DNA-encoded chemical libraries. Antimicrob.Agents Chemother., 68, 2024
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9EOR
| SARS-CoV2 major protease in complex with a covalent inhibitor SLL12. | Descriptor: | 3C-like proteinase nsp5, Inhibitor SLL12, POTASSIUM ION | Authors: | Moche, M, Lennerstrand, J, Nyman, T, Strandback, E, Akaberi, D. | Deposit date: | 2024-03-15 | Release date: | 2024-09-04 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Identification of novel and potent inhibitors of SARS-CoV-2 main protease from DNA-encoded chemical libraries. Antimicrob.Agents Chemother., 68, 2024
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9EOX
| SARS-CoV2 major protease in covalent complex with a soluble inhibitor. | Descriptor: | 3C-like proteinase nsp5, POTASSIUM ION, Soluble inhibitor | Authors: | Moche, M, Lennerstrand, J, Nyman, T, Strandback, E, Akaberi, D. | Deposit date: | 2024-03-15 | Release date: | 2024-09-04 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (2.54 Å) | Cite: | Identification of novel and potent inhibitors of SARS-CoV-2 main protease from DNA-encoded chemical libraries. Antimicrob.Agents Chemother., 68, 2024
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8AJ1
| SARS-CoV-2 Mpro in Complex with RK-107 | Descriptor: | (2R,3S)-3-[[(2S)-3-cyclopropyl-2-[2-oxidanylidene-3-(phenylcarbamoylamino)pyridin-1-yl]propanoyl]amino]-N-methyl-2-oxidanyl-4-[(3S)-2-oxidanylidenepyrrolidin-3-yl]butanamide, 3C-like proteinase nsp5 | Authors: | El Kilani, H, Hilgenfeld, R. | Deposit date: | 2022-07-27 | Release date: | 2024-09-11 | Last modified: | 2024-09-18 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | SARS-CoV-2 Mpro in Complex with RK-107 To Be Published
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8Y4A
| BA.2.86 S-trimer in complex with Nab XG2v046 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | Authors: | Zhu, Q, Liu, P. | Deposit date: | 2024-01-30 | Release date: | 2024-09-11 | Last modified: | 2024-10-09 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Enhancing RBD exposure and S1 shedding by an extremely conserved SARS-CoV-2 NTD epitope. Signal Transduct Target Ther, 9, 2024
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8U3O
| SARS-CoV-2 Main Protease A173V in complex with CDD-1819 | Descriptor: | (2P)-2-(isoquinolin-4-yl)-1-[(1s,3R)-3-(methylcarbamoyl)cyclobutyl]-N-[(1S)-1-(naphthalen-2-yl)ethyl]-1H-benzimidazole-7-carboxamide, ORF1a polyprotein | Authors: | Nnabuife, C, Palzkill, T. | Deposit date: | 2023-09-08 | Release date: | 2024-09-18 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | SARS-CoV-2 Main Protease A173V in complex with CDD-1819 To Be Published
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8ZBQ
| Local map of Omicron Subvariant JN.1 RBD with ACE2 | Descriptor: | Angiotensin-converting enzyme 2, Spike protein S2' | Authors: | Yan, R.H, Yang, H.N. | Deposit date: | 2024-04-27 | Release date: | 2024-09-18 | Last modified: | 2024-09-25 | Method: | ELECTRON MICROSCOPY (3.03 Å) | Cite: | Structural basis for the evolution and antibody evasion of SARS-CoV-2 BA.2.86 and JN.1 subvariants. Nat Commun, 15, 2024
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9ATO
| XBB.1.5 spike/Nanosota-3C complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nanosota-3C, ... | Authors: | Ye, G, Bu, F, Liu, B, Li, F. | Deposit date: | 2024-02-27 | Release date: | 2024-09-18 | Last modified: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structure of XBB.1.5 spike/Nanosota-3C complex To Be Published
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9ATP
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8U9H
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8U9K
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8U9M
| Structure of the SARS-CoV-2 main protease in complex with inhibitor MPI95 | Descriptor: | 3C-like proteinase nsp5, bis(4-fluorophenyl)methyl (1R,2S,5R)-2-({(2R)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}carbamoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-3-carboxylate | Authors: | Blankenship, L.R, Liu, W.R. | Deposit date: | 2023-09-19 | Release date: | 2024-09-25 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structure of the SARS-CoV-2 main protease in complex with inhibitors To Be Published
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8U9N
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8U9T
| Structure of the SARS-CoV-2 main protease in complex with inhibitor MPI97 | Descriptor: | (1R,2S,5S)-N~3~,N~3~-bis(4-chlorophenyl)-N~2~-{(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2,3-dicarboxamide, 3C-like proteinase nsp5 | Authors: | Blankenship, L.R, Liu, W.R. | Deposit date: | 2023-09-20 | Release date: | 2024-09-25 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structure of the SARS-CoV-2 main protease in complex with inhibitors To Be Published
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8U9U
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8U9V
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8U9W
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8WFH
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8WFM
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9DN4
| Crystal structure of a SARS-CoV-2 20-mer RNA in complex with FAB BL3-6S97N | Descriptor: | CHLORIDE ION, FAB BL3-6S97N HEAVY CHAIN, FAB BL3-6S97N LIGHT CHAIN, ... | Authors: | Lovell, S, Cooper, A, Battaile, K.P, Hegde, S, Wang, J. | Deposit date: | 2024-09-16 | Release date: | 2024-09-25 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structure of a SARS-CoV-2 20-mer RNA in complex with FAB BL3-6S97N To be published
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