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COVID-19特輯

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冠狀病毒
冠狀病毒,2020. 由David S. Goodsell @ RCSB PDB原圖修改

最近爆發的新型冠狀病毒傳染病(Novel Coronavirus disease 2019: COVID-19)對全世界的人們都構成了嚴重威脅。 為了儘早了解新病毒(Severe Acute Respiratory Syndrome Coronavirus 2: SARS-CoV-2)以開發出有效的抗病毒藥物,已經有很多科研人員開始了相關蛋白結構的研究,並且將所獲得結構數據存儲與PDB。 PDBj為用戶提供了COVID-19相關數據一覽的門戶頁面,並將於每週三更新當日新發佈的相關數據。

有關該病毒蛋白質的解說,請參見下面的“當月的分子”頁面。

“所有結構”標籤的頁面則逐一羅列了所有的數據,包括由同一研究組提交的系列數據群。 “代表性結構”標籤的頁面精選具有相同胺基酸序列的結構數據中的高分辨率數據,不重複選擇具有同一胺基酸序列的數據,即使該數據可能包含不同的配體。 “最新條目”標籤內包含本週新更新數據。


Created: 2020-09-03 (last edited: more than 1 year ago)2022-09-02
7BEI
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BU of 7bei by Molmil
Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-150 Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, COVOX-150 heavy chain, ...
Authors:Zhou, D, Zhao, Y, Ren, J, Stuart, D.
Deposit date:2020-12-23
Release date:2021-03-03
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The antigenic anatomy of SARS-CoV-2 receptor binding domain.
Cell, 184, 2021
7BEK
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BU of 7bek by Molmil
Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-158 Fab (crystal form 2)
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
Authors:Zhou, D, Zhao, Y, Ren, J, Stuart, D.
Deposit date:2020-12-23
Release date:2021-03-03
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:The antigenic anatomy of SARS-CoV-2 receptor binding domain.
Cell, 184, 2021
7BEL
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BU of 7bel by Molmil
Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in a ternary complex with COVOX-88 and COVOX-45 Fabs
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, COVOX-45 heavy chain, ...
Authors:Zhou, D, Zhao, Y, Ren, J, Stuart, D.
Deposit date:2020-12-23
Release date:2021-03-03
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:The antigenic anatomy of SARS-CoV-2 receptor binding domain.
Cell, 184, 2021
7BEM
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BU of 7bem by Molmil
Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-269 scFv
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, COVOX-269 Vh domain, ...
Authors:Zhou, D, Zhao, Y, Ren, J, Stuart, D.
Deposit date:2020-12-24
Release date:2021-03-03
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:The antigenic anatomy of SARS-CoV-2 receptor binding domain.
Cell, 184, 2021
7BEN
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BU of 7ben by Molmil
Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in a ternary complex with COVOX-253 and COVOX-75 Fabs
Descriptor: 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, BROMIDE ION, ...
Authors:Zhou, D, Zhao, Y, Ren, J, Stuart, D.
Deposit date:2020-12-24
Release date:2021-03-03
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The antigenic anatomy of SARS-CoV-2 receptor binding domain.
Cell, 184, 2021
7BEO
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BU of 7beo by Molmil
Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in a ternary complex with COVOX-253H55L and COVOX-75 Fabs
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ...
Authors:Zhou, D, Zhao, Y, Ren, J, Stuart, D.
Deposit date:2020-12-24
Release date:2021-03-03
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (3.19 Å)
Cite:The antigenic anatomy of SARS-CoV-2 receptor binding domain.
Cell, 184, 2021
7BEP
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BU of 7bep by Molmil
Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in a ternary complex with COVOX-384 and S309 Fabs
Descriptor: CHLORIDE ION, COVOX-384 heavy chain, COVOX-384 light chain, ...
Authors:Zhou, D, Zhao, Y, Ren, J, Stuart, D.
Deposit date:2020-12-24
Release date:2021-03-03
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:The antigenic anatomy of SARS-CoV-2 receptor binding domain.
Cell, 184, 2021
7CI3
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BU of 7ci3 by Molmil
The crystal structure of the SARS-CoV-2 ORF7a ectodomain
Descriptor: Orf7a protein
Authors:Zhou, Z, Zhou, Z, Chen, S.
Deposit date:2020-07-07
Release date:2021-03-03
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural insight reveals SARS-CoV-2 ORF7a as an immunomodulating factor for human CD14 + monocytes.
Iscience, 24, 2021
7LOP
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BU of 7lop by Molmil
Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies CV05-163 and CR3022
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CR3022 Fab heavy chain, CR3022 Fab light chain, ...
Authors:Yuan, M, Zhu, X, Wilson, I.A.
Deposit date:2021-02-10
Release date:2021-03-03
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.246 Å)
Cite:Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants.
Science, 373, 2021
7ND3
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BU of 7nd3 by Molmil
EM structure of SARS-CoV-2 Spike glycoprotein in complex with COVOX-40 Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, COVOX-40 heavy chain, ...
Authors:Duyvesteyn, H.M.E, Zhao, Y, Ren, J, Stuart, D.
Deposit date:2021-01-30
Release date:2021-03-03
Last modified:2025-07-02
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:The antigenic anatomy of SARS-CoV-2 receptor binding domain.
Cell, 184, 2021
7ND4
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BU of 7nd4 by Molmil
EM structure of SARS-CoV-2 Spike glycoprotein in complex with COVOX-88 Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, COVOX-88 Fab heavy chain, ...
Authors:Duyvesteyn, H.M.E, Zhao, Y, Ren, J, Stuart, D.
Deposit date:2021-01-30
Release date:2021-03-03
Last modified:2024-10-09
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:The antigenic anatomy of SARS-CoV-2 receptor binding domain.
Cell, 184, 2021
7ND5
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BU of 7nd5 by Molmil
EM structure of SARS-CoV-2 Spike glycoprotein in complex with COVOX-150 Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, COVOX-150 Fab heavy chain, ...
Authors:Duyvesteyn, H.M.E, Zhao, Y, Ren, J, Stuart, D.
Deposit date:2021-01-30
Release date:2021-03-03
Last modified:2025-07-02
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:The antigenic anatomy of SARS-CoV-2 receptor binding domain.
Cell, 184, 2021
7ND6
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BU of 7nd6 by Molmil
EM structure of SARS-CoV-2 Spike glycoprotein in complex with COVOX-40 Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, COVOX-158 Fab heavy chain, ...
Authors:Duyvesteyn, H.M.E, Zhao, Y, Ren, J, Stuart, D.
Deposit date:2021-01-30
Release date:2021-03-03
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (7.3 Å)
Cite:The antigenic anatomy of SARS-CoV-2 receptor binding domain.
Cell, 184, 2021
7ND7
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BU of 7nd7 by Molmil
EM structure of SARS-CoV-2 Spike glycoprotein in complex with COVOX-316 Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Duyvesteyn, H.M.E, Zhao, Y, Ren, J, Stuart, D.
Deposit date:2021-01-30
Release date:2021-03-03
Last modified:2025-07-02
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:The antigenic anatomy of SARS-CoV-2 receptor binding domain.
Cell, 184, 2021
7ND8
DownloadVisualize
BU of 7nd8 by Molmil
EM structure of SARS-CoV-2 Spike glycoprotein in complex with COVOX-384 Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, COVOX-384 Fab heavy chain, ...
Authors:Duyvesteyn, H.M.E, Zhao, Y, Ren, J, Stuart, D.
Deposit date:2021-01-30
Release date:2021-03-03
Last modified:2025-07-02
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:The antigenic anatomy of SARS-CoV-2 receptor binding domain.
Cell, 184, 2021
7ND9
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BU of 7nd9 by Molmil
EM structure of SARS-CoV-2 Spike glycoprotein (one RBD up) in complex with COVOX-253H55L Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Duyvesteyn, H.M.E, Zhao, Y, Ren, J, Stuart, D.
Deposit date:2021-01-30
Release date:2021-03-03
Last modified:2025-07-02
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:The antigenic anatomy of SARS-CoV-2 receptor binding domain.
Cell, 184, 2021
7NDB
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BU of 7ndb by Molmil
EM structure of SARS-CoV-2 Spike glycoprotein in complex with COVOX-253H165L Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Duyvesteyn, H.M.E, Zhao, Y, Ren, J, Stuart, D.
Deposit date:2021-01-30
Release date:2021-03-03
Last modified:2024-10-16
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:The antigenic anatomy of SARS-CoV-2 receptor binding domain.
Cell, 184, 2021
7NDC
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BU of 7ndc by Molmil
EM structure of SARS-CoV-2 Spike glycoprotein (all RBD down) in complex with COVOX-159
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, COVOX-159 Fab light chain, ...
Authors:Duyvesteyn, H.M.E, Zhao, Y, Ren, J, Stuart, D.
Deposit date:2021-01-30
Release date:2021-03-03
Last modified:2025-07-02
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:The antigenic anatomy of SARS-CoV-2 receptor binding domain.
Cell, 184, 2021
7NEG
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BU of 7neg by Molmil
Crystal structure of the N501Y mutant receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-269 Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody COVOX-269 Fab heavy chain, Antibody COVOX-269 Fab light chain, ...
Authors:Zhou, D, Ren, J, Stuart, D.
Deposit date:2021-02-04
Release date:2021-03-03
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Reduced neutralization of SARS-CoV-2 B.1.1.7 variant by convalescent and vaccine sera.
Cell, 184, 2021
7NEH
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BU of 7neh by Molmil
Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-269 Fab
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
Authors:Zhou, D, Ren, J, Stuart, D.
Deposit date:2021-02-04
Release date:2021-03-03
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Reduced neutralization of SARS-CoV-2 B.1.1.7 variant by convalescent and vaccine sera.
Cell, 184, 2021
7CZP
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BU of 7czp by Molmil
S protein of SARS-CoV-2 in complex bound with P2B-1A1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IG c181_light_IGLV2-14_IGLJ3,IGL@ protein, ...
Authors:Yan, R.H, Zhang, Y.Y, Li, Y.N, Zhou, Q.
Deposit date:2020-09-09
Release date:2021-03-10
Last modified:2024-10-16
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies.
Cell Res., 31, 2021
7CZQ
DownloadVisualize
BU of 7czq by Molmil
S protein of SARS-CoV-2 in complex bound with P2B-1A10
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IG c642_heavy_IGHV3-53_IGHD1-26_IGHJ6,Chain H of P2B-1A10,Immunoglobulin gamma-1 heavy chain, ...
Authors:Yan, R.H, Zhang, Y.Y, Li, Y.N, Zhou, Q.
Deposit date:2020-09-09
Release date:2021-03-10
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies.
Cell Res., 31, 2021
7CZT
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BU of 7czt by Molmil
S protein of SARS-CoV-2 in complex bound with P5A-2G9
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IG c689_light_IGLV5-37_IGLJ3,IGL@ protein, ...
Authors:Yan, R.H, Zhang, Y.Y, Li, Y.N, Zhou, Q.
Deposit date:2020-09-09
Release date:2021-03-10
Last modified:2024-11-06
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies.
Cell Res., 31, 2021
7CZV
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BU of 7czv by Molmil
S protein of SARS-CoV-2 in complex bound with P5A-1B6_3B
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Immunoglobulin heavy variable 3-30-3,chain H of P5A-1B6_3B,Immunoglobulin gamma-1 heavy chain, ...
Authors:Yan, R.H, Zhang, Y.Y, Li, Y.N, Zhou, Q.
Deposit date:2020-09-09
Release date:2021-03-10
Last modified:2024-10-09
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies.
Cell Res., 31, 2021
7CZW
DownloadVisualize
BU of 7czw by Molmil
S protein of SARS-CoV-2 in complex bound with P5A-2G7
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IGL c2312_light_IGLV2-14_IGLJ2,IGL@ protein, ...
Authors:Yan, R.H, Zhang, Y.Y, Li, Y.N, Zhou, Q.
Deposit date:2020-09-09
Release date:2021-03-10
Last modified:2024-10-16
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies.
Cell Res., 31, 2021

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數據於2025-07-02公開中

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