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COVID-19特辑

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冠状病毒
冠状病毒,2020. 由David S. Goodsell @ RCSB PDB原图修改

最近爆发的新型冠状病毒传染病(Novel Coronavirus disease 2019: COVID-19)对全世界的人们都构成了严重威胁。 为了尽早了解新病毒(Severe Acute Respiratory Syndrome Coronavirus 2: SARS-CoV-2)以开发出有效的抗病毒药物,已经有很多科研人員开始了相关蛋白结构的研究,并且将所获得的结构数据存储于PDB。 PDBj为用户提供了COVID-19相关数据一览的门户页面,并将于每周三更新当日新发布的相关数据。

有关该病毒蛋白质的解说,请参见下面的“当月的分子”页面。

“所有结构”标签的页面则逐一罗列了所有的结构数据,包括由同一研究组提交的系列数据群。 “代表性结构”标签的页面精选具有相同氨基酸序列的结构数据中的高分辨率数据,不重复选择具同一氨基酸序列的数据,即使该数据可能包含不同配体。 “最新条目”标签内包含本周新更新数据。


Created: 2020-09-03 (last edited: more than 1 year ago)2020-12-02
8YZ5
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BU of 8yz5 by Molmil
SARS-CoV-2 Delta Spike in complex with Fab of JE-5C
Descriptor: Fab heavy chain of JE-5C, Fab light chain of JE-5C, Spike glycoprotein
Authors:Chen, X, Wu, Y.-M.
Deposit date:2024-04-06
Release date:2024-06-05
Last modified:2024-11-06
Method:ELECTRON MICROSCOPY (3.93 Å)
Cite:The presence of broadly neutralizing anti-SARS-CoV-2 RBD antibodies elicited by primary series and booster dose of COVID-19 vaccine.
Plos Pathog., 20, 2024
8YZ6
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BU of 8yz6 by Molmil
SARS-CoV-2 Spike (BA.1) in complex with Fab of JH-8B
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab heavy chain of JH-8B, ...
Authors:Chen, X, Wu, Y.-M.
Deposit date:2024-04-06
Release date:2024-06-05
Last modified:2024-11-06
Method:ELECTRON MICROSCOPY (4.55 Å)
Cite:The presence of broadly neutralizing anti-SARS-CoV-2 RBD antibodies elicited by primary series and booster dose of COVID-19 vaccine.
Plos Pathog., 20, 2024
9FGR
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BU of 9fgr by Molmil
SARS-CoV-2 (wuhan variant) Spike protein in complex with the single chain fragment scFv76-77 (focused refinement)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, scFv76-77 single chain fragment
Authors:Berlinguer, M, Chaves-Sanjuan, A, Milazzo, F.M, Minenkova, O, De Santis, R, Bolognesi, M.
Deposit date:2024-05-25
Release date:2024-06-05
Last modified:2024-10-09
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structure of scFv76-77 in complex with SARS-CoV-2 Spike protein
To Be Published
8JMM
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BU of 8jmm by Molmil
Structure of XBB spike protein (S) dimer-trimer in complex with bispecific antibody G7-Fc at 3.75 Angstroms resolution.
Descriptor: 7F3 Fv, GW01 Fv, Spike glycoprotein
Authors:Hao, A, Mao, Q, Chen, Z, Huang, J, Sun, L.
Deposit date:2023-06-05
Release date:2024-06-12
Last modified:2024-11-20
Method:ELECTRON MICROSCOPY (3.75 Å)
Cite:Structure of XBB spike protein (S) dimer-trimer in complex with bispecific antibody G7-Fc at 3.75 Angstroms resolution.
To Be Published
8JYS
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BU of 8jys by Molmil
SARS-CoV-2 Spike RBD (dimer) in complex with two 2S-1244 nanobodies
Descriptor: IBT-CoV144 nanobody, Spike protein S1
Authors:Yang, Y, Zhang, C.H.
Deposit date:2023-07-03
Release date:2024-06-12
Last modified:2024-11-06
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:A novel nanobody broadly neutralizes SARS-CoV-2 via induction of spike trimer dimers conformation.
Exploration (Beijing), 4, 2024
8UIR
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BU of 8uir by Molmil
SARS-CoV-2 Omicron-XBB.1.16 3-RBD down Spike Protein Trimer consensus (S-GSAS-Omicron-XBB.1.16)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:Zhang, Q.E, Acharya, P.
Deposit date:2023-10-10
Release date:2024-06-12
Last modified:2024-11-06
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:SARS-CoV-2 Omicron XBB lineage spike structures, conformations, antigenicity, and receptor recognition.
Mol.Cell, 84, 2024
8V0L
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BU of 8v0l by Molmil
SARS-CoV-2 Omicron-XBB.1.16 3-RBD-down Spike Protein Trimer 1 (S-RRAR-Omicron-XBB.1.16)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:Zhang, Q.E, Acharya, P.
Deposit date:2023-11-17
Release date:2024-06-12
Last modified:2024-11-06
Method:ELECTRON MICROSCOPY (3 Å)
Cite:SARS-CoV-2 Omicron XBB lineage spike structures, conformations, antigenicity, and receptor recognition.
Mol.Cell, 84, 2024
8XZD
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BU of 8xzd by Molmil
The structure of fox ACE2 and Omicron BF.7 RBD complex
Descriptor: Angiotensin-converting enzyme, Spike protein S1, ZINC ION
Authors:sun, J.Q.
Deposit date:2024-01-21
Release date:2024-06-12
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (3.47 Å)
Cite:The binding and structural basis of fox ACE2 to RBDs from different sarbecoviruses.
Virol Sin, 39, 2024
9AYW
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BU of 9ayw by Molmil
SARS-CoV-2 Omicron-EG.5.1 3-RBD down Spike Protein Trimer 1 (S-GSAS-Omicron-EG.5.1)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:Zhang, Q.E, Acharya, P.
Deposit date:2024-03-08
Release date:2024-06-12
Last modified:2024-11-06
Method:ELECTRON MICROSCOPY (3 Å)
Cite:SARS-CoV-2 Omicron XBB lineage spike structures, conformations, antigenicity, and receptor recognition.
Mol.Cell, 84, 2024
9FGS
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BU of 9fgs by Molmil
SARS-CoV-2 (wuhan variant) Spike protein in complex with the single chain fragment scFv41N (focused refinement)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Single Chain fragment scFv41N, Spike glycoprotein,Fibritin
Authors:Berlinguer, M, Chaves-Sanjuan, A, Milazzo, F.M, Minenkova, O, De Santis, R, Bolognesi, M.
Deposit date:2024-05-25
Release date:2024-06-12
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structure of scFv41N in complex with SARS-CoV-2 Spike protein
To Be Published
9FGT
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BU of 9fgt by Molmil
SARS-CoV-2 (B.1.1.529/Omicron variant) Spike protein in complex with the single chain fragment scFv76 (focused refinement)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Single chain fragment scFv76, Spike glycoprotein,Fibritin
Authors:Berlinguer, M, Chaves-Sanjuan, A, Milazzo, F.M, Minenkova, O, De Santis, R, Bolognesi, M.
Deposit date:2024-05-25
Release date:2024-06-12
Last modified:2024-11-20
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structure of scFv76 in complex with SARS-CoV-2 Omicron Spike protein
To Be Published
9FGU
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BU of 9fgu by Molmil
SARS-CoV-2 (B.1.1.529/Omicron variant) Spike protein in complex with the single chain fragment scFv76-77 (focused refinement)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,Fibritin, scFv76-77 single chain fragment
Authors:Berlinguer, M, Chaves-Sanjuan, A, Milazzo, F.M, Minenkova, O, De Santis, R, Bolognesi, M.
Deposit date:2024-05-25
Release date:2024-06-12
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structure of scFv76-77 in complex with SARS-CoV-2 Omicron Spike protein
To Be Published
8C0Y
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BU of 8c0y by Molmil
SARS-CoV2 Omicron BA.1 RBD in complex with CAB-A17 antibody
Descriptor: CAB-A17 antibody (variable), Spike protein S2'
Authors:Das, H, Hallberg, B.M.
Deposit date:2022-12-19
Release date:2024-06-19
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (2.68 Å)
Cite:Structural basis of broad SARS-CoV-2 cross-neutralization by affinity-matured public antibodies.
Cell Rep Med, 5, 2024
8QH0
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BU of 8qh0 by Molmil
Crystal structure of the SARS-CoV-2 RBD with the antibody Cv2.3194
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cv2.3194 Heavy chain, GLYCEROL, ...
Authors:Fernandez, I, Rey, F.A.
Deposit date:2023-09-06
Release date:2024-06-19
Last modified:2025-07-02
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Broad sarbecovirus neutralization by combined memory B cell antibodies to ancestral SARS-CoV-2.
Iscience, 27, 2024
8QH1
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BU of 8qh1 by Molmil
Crystal structure of the SARS-CoV-2 RBD from the Omicron BA4 variant with the antibody Cv2.3194
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Cv2.3194 heavy chain, IGK@ protein, ...
Authors:Fernandez, I, Rey, F.A.
Deposit date:2023-09-06
Release date:2024-06-19
Last modified:2025-07-02
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Broad sarbecovirus neutralization by combined memory B cell antibodies to ancestral SARS-CoV-2.
Iscience, 27, 2024
8UKD
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BU of 8ukd by Molmil
SARS-CoV-2 Omicron-XBB.1.5 3-RBD down Spike Protein Trimer consensus (S-GSAS-Omicron-XBB.1.5)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:Zhang, Q.E, Acharya, P.
Deposit date:2023-10-12
Release date:2024-06-19
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:SARS-CoV-2 Omicron XBB lineage spike structures, conformations, antigenicity, and receptor recognition.
Mol.Cell, 84, 2024
8UKF
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BU of 8ukf by Molmil
SARS-CoV-2 Omicron-EG.5 3-RBD down Spike Protein Trimer consensus (S-GSAS-Omicron-EG.5)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:Zhang, Q.E, Acharya, P.
Deposit date:2023-10-12
Release date:2024-06-19
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:SARS-CoV-2 Omicron XBB lineage spike structures, conformations, antigenicity, and receptor recognition.
Mol.Cell, 84, 2024
8XBF
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BU of 8xbf by Molmil
Cryo-EM structure of SARS-CoV-2 S-BQ.1 in complex with antibody O5C2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, O5C2, heavy chain, ...
Authors:Hsu, H.F, Wu, M.H, Chang, Y.C, Hsu, S.T.D.
Deposit date:2023-12-06
Release date:2024-06-19
Last modified:2025-06-25
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Functional and structural investigation of a broadly neutralizing SARS-CoV-2 antibody.
JCI Insight, 9, 2024
8XXW
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BU of 8xxw by Molmil
Fab M2-7 complexed with SARS-Cov2 RBD and human ACE2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, M2-7-Heavy chain, M2-7-Light chain, ...
Authors:Liu, C, Xie, Y.
Deposit date:2024-01-19
Release date:2024-06-19
Last modified:2025-07-02
Method:ELECTRON MICROSCOPY (3.03 Å)
Cite:Mosaic RBD nanoparticle elicits immunodominant antibody responses across sarbecoviruses.
Cell Rep, 43, 2024
8YB5
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BU of 8yb5 by Molmil
SARS-CoV-2 DMV nsp3-4 pore complex (consensus-pore, C6 symmetry)
Descriptor: Non-structural protein 4, Papain-like protease nsp3
Authors:Huang, Y.X, Zhong, L.J, Zhang, W.X, Ni, T.
Deposit date:2024-02-11
Release date:2024-06-19
Last modified:2024-10-16
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Molecular architecture of coronavirus double-membrane vesicle pore complex.
Nature, 633, 2024
9EOW
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BU of 9eow by Molmil
The 5-terminal stem-loop RNA element of SARS-CoV-2 features highly dynamic structural elements that are sensitive to differences in cellular pH
Descriptor: RNA (29-MER)
Authors:Wacker, A, Schwalbe, H.
Deposit date:2024-03-15
Release date:2024-06-19
Last modified:2024-07-31
Method:SOLUTION NMR
Cite:The 5'-terminal stem-loop RNA element of SARS-CoV-2 features highly dynamic structural elements that are sensitive to differences in cellular pH.
Nucleic Acids Res., 52, 2024
8T7Y
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BU of 8t7y by Molmil
Structure of SARS CoV-2 main protease in complex with Chymostatin.
Descriptor: 3C-like proteinase nsp5, Chymostatin A (bound form)
Authors:Terzyan, S, Yarla, N, Rao, C.V, Mooers, B.
Deposit date:2023-06-21
Release date:2024-06-26
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structure of SARS CoV-2 main protease in complex with Chymostatin.
to be published
8WHZ
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BU of 8whz by Molmil
BA.2.86 RBD in complex with hACE2 (local refinement)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Processed angiotensin-converting enzyme 2, ...
Authors:Yue, C, Liu, P.
Deposit date:2023-09-23
Release date:2024-06-26
Last modified:2024-11-06
Method:ELECTRON MICROSCOPY (3.93 Å)
Cite:Spike N354 glycosylation augments SARS-CoV-2 fitness for human adaptation through structural plasticity.
Natl Sci Rev, 11, 2024
8X4Z
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BU of 8x4z by Molmil
BA.2.86 Spike Trimer with ins483V mutation (3 RBD down)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Yue, C, Liu, P.
Deposit date:2023-11-16
Release date:2024-06-26
Last modified:2024-11-06
Method:ELECTRON MICROSCOPY (3.49 Å)
Cite:Spike N354 glycosylation augments SARS-CoV-2 fitness for human adaptation through structural plasticity.
Natl Sci Rev, 11, 2024
8OYT
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BU of 8oyt by Molmil
Stabilised BA.1 SARS-CoV-2 spike with H6 nanobodies in '3 up' RBD conformation
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, H6 nanobody, ...
Authors:Weckener, M, Naismith, J.H, Owens, R.J.
Deposit date:2023-05-05
Release date:2024-07-03
Last modified:2024-11-06
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structural and functional characterization of nanobodies that neutralize Omicron variants of SARS-CoV-2.
Open Biology, 14, 2024

238582

数据于2025-07-09公开中

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