COVID-19特辑

冠状病毒，2020. 由David S. Goodsell @ RCSB PDB原图修改

最近爆发的新型冠状病毒传染病（Novel Coronavirus disease 2019: COVID-19）对全世界的人们都构成了严重威胁。为了尽早了解新病毒（Severe Acute Respiratory Syndrome Coronavirus 2: SARS-CoV-2）以开发出有效的抗病毒药物，已经有很多科研人員开始了相关蛋白结构的研究，并且将所获得的结构数据存储于PDB。 PDBj为用户提供了COVID-19相关数据一览的门户页面，并将于每周三更新当日新发布的相关数据。

有关该病毒蛋白质的解说，请参见下面的“当月的分子”页面。

“所有结构”标签的页面则逐一罗列了所有的结构数据，包括由同一研究组提交的系列数据群。 “代表性结构”标签的页面精选具有相同氨基酸序列的结构数据中的高分辨率数据，不重复选择具同一氨基酸序列的数据，即使该数据可能包含不同配体。 “最新条目”标签内包含本周新更新数据。

Created: 2020-09-03 (last edited: more than 1 year ago)

所有结构 (5197)代表性结构 (2266)最新条目 (44)

9FCM

Single-domain antibody binding the SARS-COV2 S2
Descriptor:	CHLORIDE ION, Single-domain antibody R3DC23, Spike protein S2'
Authors:	Vann Molle, I, Remaut, H.
Deposit date:	2024-05-15
Release date:	2025-05-21
Last modified:	2025-06-11
Method:	X-RAY DIFFRACTION (1.94 Å)
Cite:	Ultrapotent SARS coronavirus-neutralizing single-domain antibodies that clamp the spike at its base. Nat Commun, 16, 2025

9UJ2

14-3-3 zeta chimera with the S202R peptide of SARS-CoV-2 N (residues 200-213)
Descriptor:	1,2-ETHANEDIOL, 14-3-3 protein zeta/delta,Peptide from Nucleoprotein, DI(HYDROXYETHYL)ETHER
Authors:	Boyko, K.M, Matyuta, I.O, Minyaev, M.E, Perfilova, K.V, Sluchanko, N.N.
Deposit date:	2025-04-16
Release date:	2025-05-21
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	High-resolution structure reveals enhanced 14-3-3 binding by a mutant SARS-CoV-2 nucleoprotein variant with improved replicative fitness. Biochem.Biophys.Res.Commun., 767, 2025

9ELE

Cryo-EM structure of SARS-CoV-2 Omicron KP.3.1.1 RBD in complex with human ACE2 (local refinement of RBD and hACE2)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, ...
Authors:	Feng, Z, Huang, J, Ward, A.B.
Deposit date:	2024-12-04
Release date:	2025-05-28
Method:	ELECTRON MICROSCOPY (3.16 Å)
Cite:	Structure of SARS-CoV-2 KP.3.1.1 Spike Protein To Be Published

9ELF

Cryo-EM structure of SARS-CoV-2 Omicron KP.3.1.1 spike protein in complex with human ACE2
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, ...
Authors:	Feng, Z, Huang, J, Ward, A.B.
Deposit date:	2024-12-04
Release date:	2025-05-28
Method:	ELECTRON MICROSCOPY (2.88 Å)
Cite:	Structure of SARS-CoV-2 KP.3.1.1 Spike Protein To Be Published

9ELG

Cryo-EM structure of SARS-CoV-2 Omicron KP.3.1.1 spike RBD and NTD (local refinement of RBD and NTD)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1
Authors:	Feng, Z, Huang, J, Ward, A.B.
Deposit date:	2024-12-04
Release date:	2025-05-28
Method:	ELECTRON MICROSCOPY (3.71 Å)
Cite:	Structure of SARS-CoV-2 KP.3.1.1 Spike Protein To Be Published

9ELH

Cryo-EM structure of SARS-CoV-2 Omicron KP.3.1.1 spike protein (one RBD up state)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
Authors:	Feng, Z, Huang, J, Ward, A.B.
Deposit date:	2024-12-04
Release date:	2025-05-28
Method:	ELECTRON MICROSCOPY (2.98 Å)
Cite:	Structure of SARS-CoV-2 KP.3.1.1 Spike Protein To Be Published

9ELI

Cryo-EM structure of SARS-CoV-2 Omicron KP.3.1.1 spike protein (closed state)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
Authors:	Feng, Z, Huang, J, Ward, A.B.
Deposit date:	2024-12-04
Release date:	2025-05-28
Method:	ELECTRON MICROSCOPY (2.82 Å)
Cite:	Structure of SARS-CoV-2 KP.3.1.1 Spike Protein To Be Published

9ELN

Cryo-EM structure of SARS-CoV-2 Omicron JN.1.11+S31 deletion spike protein (one RBD up state)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
Authors:	Feng, Z, Huang, J, Ward, A.B.
Deposit date:	2024-12-04
Release date:	2025-05-28
Method:	ELECTRON MICROSCOPY (2.93 Å)
Cite:	Structure of SARS-CoV-2 KP.3.1.1 Spike Protein To Be Published

9ELO

Cryo-EM structure of SARS-CoV-2 Omicron JN.1.11+S31 deletion spike protein (closed state)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
Authors:	Feng, Z, Huang, J, Ward, A.B.
Deposit date:	2024-12-04
Release date:	2025-05-28
Method:	ELECTRON MICROSCOPY (2.74 Å)
Cite:	Structure of SARS-CoV-2 KP.3.1.1 Spike Protein To Be Published

9ELP

Cryo-EM structure of SARS-CoV-2 Omicron JN.1.11.1+S31 deletion spike protein (one RBD up state)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
Authors:	Feng, Z, Huang, J, Ward, A.B.
Deposit date:	2024-12-04
Release date:	2025-05-28
Method:	ELECTRON MICROSCOPY (2.94 Å)
Cite:	Structure of SARS-CoV-2 KP.3.1.1 Spike Protein To Be Published

9ELQ

Cryo-EM structure of SARS-CoV-2 Omicron JN.1.11.1+S31 deletion spike protein (closed state)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
Authors:	Feng, Z, Huang, J, Ward, A.B.
Deposit date:	2024-12-04
Release date:	2025-05-28
Method:	ELECTRON MICROSCOPY (2.64 Å)
Cite:	Structure of SARS-CoV-2 KP.3.1.1 Spike Protein To Be Published

9HH5

Crystal Structure of nsp15 Endoribonuclease from SARS CoV-2 in Complex with Sepantronium (YM-155)
Descriptor:	1-(2-methoxyethyl)-2-methyl-3-(pyrazin-2-ylmethyl)benzo[f]benzimidazol-3-ium-4,9-dione, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Nsp15 - Uridylate-specific endoribonuclease, ...
Authors:	Chatziefthymiou, S.D, Kolbe, M, Hakanpaeae, J, Labahn, J, Windshuegel, B.
Deposit date:	2024-11-21
Release date:	2025-05-28
Method:	X-RAY DIFFRACTION (2.08 Å)
Cite:	Identification, validation, and characterization of approved and investigational drugs interfering with the SARS-CoV-2 endoribonuclease Nsp15. Protein Sci., 34, 2025

9HH6

Crystal Structure of Nsp15 Endoribonuclease from SARS CoV-2 in Complex with TAS-103
Descriptor:	1,2-ETHANEDIOL, 6-[2-(dimethylamino)ethylamino]-3-oxidanyl-indeno[2,1-c]quinolin-7-one, ORF1ab polyprotein, ...
Authors:	Chatziefthymiou, S.D, Kolbe, M, Hakanpaeae, J, Labahn, J, Windshuegel, B.
Deposit date:	2024-11-21
Release date:	2025-05-28
Method:	SOLUTION SCATTERING (2 Å), X-RAY DIFFRACTION
Cite:	Identification, validation, and characterization of approved and investigational drugs interfering with the SARS-CoV-2 endoribonuclease Nsp15. Protein Sci., 34, 2025

9IZB

Crystal structure of SARS-CoV-2 main protease in complex with TMP1
Descriptor:	3C-like proteinase nsp5, TMP1
Authors:	Deng, X.Y, Zeng, R, Yang, S.Y, Lei, J.
Deposit date:	2024-08-01
Release date:	2025-05-28
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Crystal structure of SARS-CoV-2 main protease in complex with TMP1 To Be Published

9ELJ

Cryo-EM structure of SARS-CoV-2 Omicron JN.1.11+Q493E+S31deletion spike protein (one RBD up state)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
Authors:	Feng, Z, Huang, J, Ward, A.B.
Deposit date:	2024-12-04
Release date:	2025-06-04
Method:	ELECTRON MICROSCOPY (2.92 Å)
Cite:	Structure of SARS-CoV-2 KP.3.1.1 Spike Protein To Be Published

9ELK

Cryo-EM structure of SARS-CoV-2 Omicron JN.1.11+Q493E+S31deletion spike protein (closed state)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
Authors:	Feng, Z, Huang, J, Ward, A.B.
Deposit date:	2024-12-04
Release date:	2025-06-04
Method:	ELECTRON MICROSCOPY (2.82 Å)
Cite:	Structure of SARS-CoV-2 KP.3.1.1 Spike Protein To Be Published

9ELL

Cryo-EM structure of SARS-CoV-2 Omicron JN.1.11 spike protein (one RBD up state)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
Authors:	Feng, Z, Huang, J, Ward, A.B.
Deposit date:	2024-12-04
Release date:	2025-06-04
Method:	ELECTRON MICROSCOPY (2.93 Å)
Cite:	Structure of SARS-CoV-2 KP.3.1.1 Spike Protein To Be Published

9ELM

Cryo-EM structure of SARS-CoV-2 Omicron JN.1.11 spike protein (closed state)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
Authors:	Feng, Z, Huang, J, Ward, A.B.
Deposit date:	2024-12-04
Release date:	2025-06-04
Method:	ELECTRON MICROSCOPY (2.68 Å)
Cite:	Structure of SARS-CoV-2 KP.3.1.1 Spike Protein To Be Published

9ML4

Structure of the SARS-CoV-2 Spike 6P in complex with the rabbit M8b-A10 Fab
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, M8b-A10 heavy chain, M8b-A10 light chain, ...
Authors:	Fan, C, Bjorkman, P.J.
Deposit date:	2024-12-18
Release date:	2025-06-04
Method:	ELECTRON MICROSCOPY (3.3 Å)
Cite:	Cross-reactive sarbecovirus antibodies induced by mosaic RBD nanoparticles. Proc.Natl.Acad.Sci.USA, 122, 2025

9ML5

Structure of the SARS-CoV-2 Spike 6P in complex with the rabbit M8b-B8 Fab
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, M8b-B8 heavy chain, ...
Authors:	Fan, C, Bjorkman, P.J.
Deposit date:	2024-12-18
Release date:	2025-06-04
Method:	ELECTRON MICROSCOPY (3.4 Å)
Cite:	Cross-reactive sarbecovirus antibodies induced by mosaic RBD nanoparticles. Proc.Natl.Acad.Sci.USA, 122, 2025

9ML6

Structure of the SARS-CoV-2 Spike 6P in complex with the rabbit M8b-C9 Fab
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, M8b-C9 heavy chain, M8b-C9 light chain, ...
Authors:	Fan, C, Bjorkman, P.J.
Deposit date:	2024-12-18
Release date:	2025-06-04
Method:	ELECTRON MICROSCOPY (3.5 Å)
Cite:	Cross-reactive sarbecovirus antibodies induced by mosaic RBD nanoparticles. Proc.Natl.Acad.Sci.USA, 122, 2025

9ML7

Structure of the SARS-CoV-2 Spike 6P in complex with the rabbit M8b-C10 Fab
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, M8b-C10 heavy chain, ...
Authors:	Fan, C, Bjorkman, P.J.
Deposit date:	2024-12-18
Release date:	2025-06-04
Method:	ELECTRON MICROSCOPY (3.2 Å)
Cite:	Cross-reactive sarbecovirus antibodies induced by mosaic RBD nanoparticles. Proc.Natl.Acad.Sci.USA, 122, 2025

9ML8

Crystal structure of the SARS-CoV-2 RBD in complex with the rabbit M8b-B1 Fab
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, M8b-B1 heavy chain, M8b-B1 light chain, ...
Authors:	Fan, C, Bjorkman, P.J.
Deposit date:	2024-12-18
Release date:	2025-06-04
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Cross-reactive sarbecovirus antibodies induced by mosaic RBD nanoparticles. Proc.Natl.Acad.Sci.USA, 122, 2025

9ML9

Crystal structure of the SARS-CoV-2 RBD in complex with the rabbit M8b-C9 Fab
Descriptor:	2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, M8b-C9 heavy chain, ...
Authors:	Fan, C, Bjorkman, P.J.
Deposit date:	2024-12-18
Release date:	2025-06-04
Method:	X-RAY DIFFRACTION (2.59 Å)
Cite:	Cross-reactive sarbecovirus antibodies induced by mosaic RBD nanoparticles. Proc.Natl.Acad.Sci.USA, 122, 2025

9MRU

Structural Asymmetry in SARS-CoV-2 Nsp15 Hexamer Important for Catalytic Activity
Descriptor:	Uridylate-specific endoribonuclease nsp15
Authors:	Ketawala, G.K, Sonowal, M, Schrag, L, Fromme, R, Botha, S, Fromme, P.
Deposit date:	2025-01-08
Release date:	2025-06-04
Method:	X-RAY DIFFRACTION (3 Å)
Cite:	Structural Asymmetry in SARS-CoV-2 Nsp15 Hexamer Important for Catalytic Activity To Be Published

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