신종 코로나바이러스 특집 콘텐츠

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코로나 바이러스, 2020. David S. Goodsell @ RCSB PDB에 의한 오리지널 일러스트를 수정

신종 코로나바이러스 감염증 (Novel Coronavirus disease 2019:COVID-19)의 확산이 세계적으로 매우 큰 문제가 되고 있습니다. 시급히 새로운 바이러스（Severe Acute Respiratory Syndrome Coronavirus 2: SARS-CoV-2）를 이해하고 효과적인 약을 개발하기 위해, 신속하게 구조 생물학 연구가 시작되고 있습니다. PDBj는 사용자의 편의를 도모하기 위해 신종 코로나바이러스의 특집 페이지를 제공하고 있습니다. 매주 수요일에 최신 항목이 추가됩니다.

바이러스 단백질에 관한 해설기사는 아래의 「이달의 분자」 페이지를 참조하십시오.

「전체 엔트리」 탭에는, 모든 PDB ID가 포함되어 있습니다. 이용자가 전체의 독립된 엔트리를 검색하고 싶을 때 사용하실 수 있으며, 동일 저자에 의한 그룹등록의 엔트리도 전부 구별되어 있습니다. 「대표구조」 탭에는, 분해능이 가장 높은 대표구조만을 표지하고 있습니다. 아미노산 서열이 100 % 일치하는 PDB 엔트리의 경우, 다른 리간드를 포함하여도 대표구조에는 제외됩니다. 「최신 엔트리」 탭은, 이번주 공개된 가장 최근의 엔트리 입니다.

Created: 2020-09-03 (last edited: more than 1 year ago)

전체 엔트리 (4406)대표구조 (1944)최신 엔트리 (19)

7TWH

Crystal structure of SARS-CoV-2 NSP3 macrodomain at 293 K (P43 crystal form, 290 kGy)
Descriptor:	Non-structural protein 3
Authors:	Correy, G.J, Fraser, J.S.
Deposit date:	2022-02-07
Release date:	2022-02-23
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (1.1 Å)
Cite:	The mechanisms of catalysis and ligand binding for the SARS-CoV-2 NSP3 macrodomain from neutron and x-ray diffraction at room temperature. Sci Adv, 8, 2022

7TWI

Crystal structure of SARS-CoV-2 NSP3 macrodomain at 293 K (P43 crystal form, 539 kGy)
Descriptor:	Non-structural protein 3
Authors:	Correy, G.J, Fraser, J.S.
Deposit date:	2022-02-07
Release date:	2022-02-23
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (1.1 Å)
Cite:	The mechanisms of catalysis and ligand binding for the SARS-CoV-2 NSP3 macrodomain from neutron and x-ray diffraction at room temperature. Sci Adv, 8, 2022

7TWJ

Crystal structure of SARS-CoV-2 NSP3 macrodomain at pH 4 (P43 crystal form)
Descriptor:	CITRIC ACID, Non-structural protein 3
Authors:	Correy, G.J, Fraser, J.S.
Deposit date:	2022-02-07
Release date:	2022-02-23
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (0.9 Å)
Cite:	The mechanisms of catalysis and ligand binding for the SARS-CoV-2 NSP3 macrodomain from neutron and x-ray diffraction at room temperature. Sci Adv, 8, 2022

7TWN

Crystal structure of SARS-CoV-2 NSP3 macrodomain at pH 5 (P43 crystal form)
Descriptor:	2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, CITRIC ACID, Non-structural protein 3
Authors:	Correy, G.J, Fraser, J.S.
Deposit date:	2022-02-07
Release date:	2022-02-23
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (0.9 Å)
Cite:	The mechanisms of catalysis and ligand binding for the SARS-CoV-2 NSP3 macrodomain from neutron and x-ray diffraction at room temperature. Sci Adv, 8, 2022

7TWO

Crystal structure of SARS-CoV-2 NSP3 macrodomain at pH 6 (P43 crystal form)
Descriptor:	2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, CITRIC ACID, Non-structural protein 3
Authors:	Correy, G.J, Fraser, J.S.
Deposit date:	2022-02-07
Release date:	2022-02-23
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (0.9 Å)
Cite:	The mechanisms of catalysis and ligand binding for the SARS-CoV-2 NSP3 macrodomain from neutron and x-ray diffraction at room temperature. Sci Adv, 8, 2022

7TWP

Crystal structure of SARS-CoV-2 NSP3 macrodomain at pH 7 (P43 crystal form)
Descriptor:	ACETATE ION, Non-structural protein 3
Authors:	Correy, G.J, Fraser, J.S.
Deposit date:	2022-02-07
Release date:	2022-02-23
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (0.9 Å)
Cite:	The mechanisms of catalysis and ligand binding for the SARS-CoV-2 NSP3 macrodomain from neutron and x-ray diffraction at room temperature. Sci Adv, 8, 2022

7TWQ

Crystal structure of SARS-CoV-2 NSP3 macrodomain at pH 9 (P43 crystal form)
Descriptor:	Non-structural protein 3
Authors:	Correy, G.J, Fraser, J.S.
Deposit date:	2022-02-07
Release date:	2022-02-23
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (0.9 Å)
Cite:	The mechanisms of catalysis and ligand binding for the SARS-CoV-2 NSP3 macrodomain from neutron and x-ray diffraction at room temperature. Sci Adv, 8, 2022

7TWR

Crystal structure of SARS-CoV-2 NSP3 macrodomain at pH 8 (P43 crystal form)
Descriptor:	ACETATE ION, Non-structural protein 3
Authors:	Correy, G.J, Fraser, J.S.
Deposit date:	2022-02-07
Release date:	2022-02-23
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (0.9 Å)
Cite:	The mechanisms of catalysis and ligand binding for the SARS-CoV-2 NSP3 macrodomain from neutron and x-ray diffraction at room temperature. Sci Adv, 8, 2022

7TWS

Crystal structure of SARS-CoV-2 NSP3 macrodomain at pH 10 (P43 crystal form)
Descriptor:	Non-structural protein 3
Authors:	Correy, G.J, Fraser, J.S.
Deposit date:	2022-02-07
Release date:	2022-02-23
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (0.9 Å)
Cite:	The mechanisms of catalysis and ligand binding for the SARS-CoV-2 NSP3 macrodomain from neutron and x-ray diffraction at room temperature. Sci Adv, 8, 2022

7TWT

Crystal structure of SARS-CoV-2 NSP3 macrodomain in complex with ADP-ribose at pH 4 (P43 crystal form)
Descriptor:	Non-structural protein 3, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE
Authors:	Correy, G.J, Fraser, J.S.
Deposit date:	2022-02-07
Release date:	2022-02-23
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (0.9 Å)
Cite:	Crystal structure of SARS-CoV-2 NSP3 macrodomain in complex with ADP-ribose at pH 4 (P43 crystal form) To Be Published

7TWV

Crystal structure of SARS-CoV-2 NSP3 macrodomain in complex with ADP-ribose at pH 5 (P43 crystal form)
Descriptor:	CITRIC ACID, Non-structural protein 3, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE
Authors:	Correy, G.J, Fraser, J.S.
Deposit date:	2022-02-07
Release date:	2022-02-23
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (0.9 Å)
Cite:	Crystal structure of SARS-CoV-2 NSP3 macrodomain in complex with ADP-ribose at pH 5 (P43 crystal form) To Be Published

7TWW

Crystal structure of SARS-CoV-2 NSP3 macrodomain in complex with ADP-ribose at pH 6 (P43 crystal form)
Descriptor:	CITRIC ACID, Non-structural protein 3, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE
Authors:	Correy, G.J, Fraser, J.S.
Deposit date:	2022-02-07
Release date:	2022-02-23
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (0.9 Å)
Cite:	Crystal structure of SARS-CoV-2 NSP3 macrodomain in complex with ADP-ribose at pH 6 (P43 crystal form) To Be Published

7TWX

Crystal structure of SARS-CoV-2 NSP3 macrodomain in complex with ADP-ribose at pH 7 (P43 crystal form)
Descriptor:	Non-structural protein 3, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE
Authors:	Correy, G.J, Fraser, J.S.
Deposit date:	2022-02-07
Release date:	2022-02-23
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (0.9 Å)
Cite:	Crystal structure of SARS-CoV-2 NSP3 macrodomain in complex with ADP-ribose at pH 7 (P43 crystal form) To Be Published

7TWY

Crystal structure of SARS-CoV-2 NSP3 macrodomain in complex with ADP-ribose at pH 8 (P43 crystal form)
Descriptor:	Non-structural protein 3, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE
Authors:	Correy, G.J, Fraser, J.S.
Deposit date:	2022-02-07
Release date:	2022-02-23
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (0.9 Å)
Cite:	Crystal structure of SARS-CoV-2 NSP3 macrodomain in complex with ADP-ribose at pH 8 (P43 crystal form) To Be Published

7TX0

Crystal structure of SARS-CoV-2 NSP3 macrodomain in complex with ADP-ribose at pH 9 (P43 crystal form)
Descriptor:	Non-structural protein 3, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE
Authors:	Correy, G.J, Fraser, J.S.
Deposit date:	2022-02-07
Release date:	2022-02-23
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (0.84 Å)
Cite:	Crystal structure of SARS-CoV-2 NSP3 macrodomain in complex with ADP-ribose at pH 9 (P43 crystal form) To Be Published

7TX1

Crystal structure of SARS-CoV-2 NSP3 macrodomain in complex with ADP-ribose at pH 10 (P43 crystal form)
Descriptor:	Non-structural protein 3, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE
Authors:	Correy, G.J, Fraser, J.S.
Deposit date:	2022-02-07
Release date:	2022-02-23
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (0.9 Å)
Cite:	Crystal structure of SARS-CoV-2 NSP3 macrodomain in complex with ADP-ribose at pH 10 (P43 crystal form) To Be Published

7TX3

Neutron crystal structure of SARS-CoV-2 NSP3 macrodomain at 293 K (P43 crystal form)
Descriptor:	2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Non-structural protein 3
Authors:	Correy, G.J, Fraser, J.S, Meilleur, F.
Deposit date:	2022-02-07
Release date:	2022-02-23
Last modified:	2023-10-25
Method:	NEUTRON DIFFRACTION (1.6 Å), X-RAY DIFFRACTION
Cite:	The mechanisms of catalysis and ligand binding for the SARS-CoV-2 NSP3 macrodomain from neutron and x-ray diffraction at room temperature. Sci Adv, 8, 2022

7TX4

Neutron crystal structure of SARS-CoV-2 NSP3 macrodomain at 293 K (P21 crystal form)
Descriptor:	Papain-like protease nsp3
Authors:	Correy, G.J, Fraser, J.S, Kovalevsky, A.
Deposit date:	2022-02-07
Release date:	2022-02-23
Last modified:	2023-10-25
Method:	NEUTRON DIFFRACTION (1.9 Å), X-RAY DIFFRACTION
Cite:	The mechanisms of catalysis and ligand binding for the SARS-CoV-2 NSP3 macrodomain from neutron and x-ray diffraction at room temperature. Sci Adv, 8, 2022

7TX5

Neutron crystal structure of SARS-CoV-2 NSP3 macrodomain in complex with ADP-ribose at 293 K (C2 crystal form)
Descriptor:	ADENOSINE-5-DIPHOSPHORIBOSE, Papain-like protease nsp3
Authors:	Correy, G.J, Fraser, J.S, Kovalevsky, A.
Deposit date:	2022-02-07
Release date:	2022-02-23
Last modified:	2023-10-25
Method:	NEUTRON DIFFRACTION (1.95 Å), X-RAY DIFFRACTION
Cite:	The mechanisms of catalysis and ligand binding for the SARS-CoV-2 NSP3 macrodomain from neutron and x-ray diffraction at room temperature. Sci Adv, 8, 2022

7E5X

THE CRYSTAL STRUCTURE OF COVID-19 MAIN PROTEASE apo form at 2.2 angstrom
Descriptor:	3C-like proteinase
Authors:	Liu, X, Zhao, Y, Yang, H, Rao, Z.
Deposit date:	2021-02-21
Release date:	2022-03-02
Last modified:	2023-11-29
Method:	X-RAY DIFFRACTION (2.19 Å)
Cite:	Structural basis for replicase polyprotein cleavage and substrate specificity of main protease from SARS-CoV-2. Proc.Natl.Acad.Sci.USA, 119, 2022

7NIJ

SARS-CoV-2 main protease (Mpro) in a novel conformational state.
Descriptor:	3C-like proteinase nsp5
Authors:	Battistutta, R, Fornasier, E, Giachin, G.
Deposit date:	2021-02-12
Release date:	2022-03-02
Last modified:	2024-01-31
Method:	X-RAY DIFFRACTION (1.58 Å)
Cite:	A new inactive conformation of SARS-CoV-2 main protease. Acta Crystallogr D Struct Biol, 78, 2022

7NTQ

Crystal structure of the SARS-CoV-2 Main Protease complexed with N-(pyridin-3-ylmethyl)thioformamide
Descriptor:	3C-like proteinase, DIMETHYL SULFOXIDE, FORMIC ACID, ...
Authors:	Dupre, E, Villeret, V, Hanoulle, X.
Deposit date:	2021-03-10
Release date:	2022-03-02
Last modified:	2024-02-07
Method:	X-RAY DIFFRACTION (1.495 Å)
Cite:	Novel dithiocarbamates selectively inhibit 3CL protease of SARS-CoV-2 and other coronaviruses. Eur.J.Med.Chem., 250, 2023

7NTT

Crystal structure of the SARS-CoV-2 Main Protease
Descriptor:	3C-like proteinase, FORMIC ACID, SODIUM ION
Authors:	Dupre, E, Villeret, V, Hanoulle, X.
Deposit date:	2021-03-10
Release date:	2022-03-02
Last modified:	2024-01-31
Method:	X-RAY DIFFRACTION (1.743 Å)
Cite:	Crystal structure of the SARS-CoV-2 Main Protease To Be Published

7NTW

Crystal structure of the SARS-CoV-2 Main Protease with a Zinc ion coordinated in the active site
Descriptor:	3C-like proteinase, DIMETHYL SULFOXIDE, FORMIC ACID, ...
Authors:	Dupre, E, Villeret, V, Hanoulle, X.
Deposit date:	2021-03-11
Release date:	2022-03-02
Last modified:	2024-01-31
Method:	X-RAY DIFFRACTION (1.815 Å)
Cite:	Crystal structure of the SARS-CoV-2 Main Protease with a Zinc ion coordinated in the active site To Be Published

7R10

Dissociated S1 domain of Alpha Variant SARS-CoV-2 Spike bound to ACE2
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, Spike glycoprotein, ...
Authors:	Benton, D.J, Wrobel, A.G, Gamblin, S.J.
Deposit date:	2022-02-02
Release date:	2022-03-02
Last modified:	2022-03-16
Method:	ELECTRON MICROSCOPY (4 Å)
Cite:	Evolution of the SARS-CoV-2 spike protein in the human host. Nat Commun, 13, 2022

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