신종 코로나바이러스 특집 콘텐츠

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코로나 바이러스, 2020. David S. Goodsell @ RCSB PDB에 의한 오리지널 일러스트를 수정

신종 코로나바이러스 감염증 (Novel Coronavirus disease 2019:COVID-19)의 확산이 세계적으로 매우 큰 문제가 되고 있습니다. 시급히 새로운 바이러스（Severe Acute Respiratory Syndrome Coronavirus 2: SARS-CoV-2）를 이해하고 효과적인 약을 개발하기 위해, 신속하게 구조 생물학 연구가 시작되고 있습니다. PDBj는 사용자의 편의를 도모하기 위해 신종 코로나바이러스의 특집 페이지를 제공하고 있습니다. 매주 수요일에 최신 항목이 추가됩니다.

바이러스 단백질에 관한 해설기사는 아래의 「이달의 분자」 페이지를 참조하십시오.

「전체 엔트리」 탭에는, 모든 PDB ID가 포함되어 있습니다. 이용자가 전체의 독립된 엔트리를 검색하고 싶을 때 사용하실 수 있으며, 동일 저자에 의한 그룹등록의 엔트리도 전부 구별되어 있습니다. 「대표구조」 탭에는, 분해능이 가장 높은 대표구조만을 표지하고 있습니다. 아미노산 서열이 100 % 일치하는 PDB 엔트리의 경우, 다른 리간드를 포함하여도 대표구조에는 제외됩니다. 「최신 엔트리」 탭은, 이번주 공개된 가장 최근의 엔트리 입니다.

Created: 2020-09-03 (last edited: more than 1 year ago)

전체 엔트리 (5197)대표구조 (2266)최신 엔트리 (44)

9FCM

Single-domain antibody binding the SARS-COV2 S2
Descriptor:	CHLORIDE ION, Single-domain antibody R3DC23, Spike protein S2'
Authors:	Vann Molle, I, Remaut, H.
Deposit date:	2024-05-15
Release date:	2025-05-21
Last modified:	2025-06-11
Method:	X-RAY DIFFRACTION (1.94 Å)
Cite:	Ultrapotent SARS coronavirus-neutralizing single-domain antibodies that clamp the spike at its base. Nat Commun, 16, 2025

9UJ2

14-3-3 zeta chimera with the S202R peptide of SARS-CoV-2 N (residues 200-213)
Descriptor:	1,2-ETHANEDIOL, 14-3-3 protein zeta/delta,Peptide from Nucleoprotein, DI(HYDROXYETHYL)ETHER
Authors:	Boyko, K.M, Matyuta, I.O, Minyaev, M.E, Perfilova, K.V, Sluchanko, N.N.
Deposit date:	2025-04-16
Release date:	2025-05-21
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	High-resolution structure reveals enhanced 14-3-3 binding by a mutant SARS-CoV-2 nucleoprotein variant with improved replicative fitness. Biochem.Biophys.Res.Commun., 767, 2025

9ELE

Cryo-EM structure of SARS-CoV-2 Omicron KP.3.1.1 RBD in complex with human ACE2 (local refinement of RBD and hACE2)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, ...
Authors:	Feng, Z, Huang, J, Ward, A.B.
Deposit date:	2024-12-04
Release date:	2025-05-28
Method:	ELECTRON MICROSCOPY (3.16 Å)
Cite:	Structure of SARS-CoV-2 KP.3.1.1 Spike Protein To Be Published

9ELF

Cryo-EM structure of SARS-CoV-2 Omicron KP.3.1.1 spike protein in complex with human ACE2
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, ...
Authors:	Feng, Z, Huang, J, Ward, A.B.
Deposit date:	2024-12-04
Release date:	2025-05-28
Method:	ELECTRON MICROSCOPY (2.88 Å)
Cite:	Structure of SARS-CoV-2 KP.3.1.1 Spike Protein To Be Published

9ELG

Cryo-EM structure of SARS-CoV-2 Omicron KP.3.1.1 spike RBD and NTD (local refinement of RBD and NTD)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1
Authors:	Feng, Z, Huang, J, Ward, A.B.
Deposit date:	2024-12-04
Release date:	2025-05-28
Method:	ELECTRON MICROSCOPY (3.71 Å)
Cite:	Structure of SARS-CoV-2 KP.3.1.1 Spike Protein To Be Published

9ELH

Cryo-EM structure of SARS-CoV-2 Omicron KP.3.1.1 spike protein (one RBD up state)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
Authors:	Feng, Z, Huang, J, Ward, A.B.
Deposit date:	2024-12-04
Release date:	2025-05-28
Method:	ELECTRON MICROSCOPY (2.98 Å)
Cite:	Structure of SARS-CoV-2 KP.3.1.1 Spike Protein To Be Published

9ELI

Cryo-EM structure of SARS-CoV-2 Omicron KP.3.1.1 spike protein (closed state)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
Authors:	Feng, Z, Huang, J, Ward, A.B.
Deposit date:	2024-12-04
Release date:	2025-05-28
Method:	ELECTRON MICROSCOPY (2.82 Å)
Cite:	Structure of SARS-CoV-2 KP.3.1.1 Spike Protein To Be Published

9ELN

Cryo-EM structure of SARS-CoV-2 Omicron JN.1.11+S31 deletion spike protein (one RBD up state)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
Authors:	Feng, Z, Huang, J, Ward, A.B.
Deposit date:	2024-12-04
Release date:	2025-05-28
Method:	ELECTRON MICROSCOPY (2.93 Å)
Cite:	Structure of SARS-CoV-2 KP.3.1.1 Spike Protein To Be Published

9ELO

Cryo-EM structure of SARS-CoV-2 Omicron JN.1.11+S31 deletion spike protein (closed state)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
Authors:	Feng, Z, Huang, J, Ward, A.B.
Deposit date:	2024-12-04
Release date:	2025-05-28
Method:	ELECTRON MICROSCOPY (2.74 Å)
Cite:	Structure of SARS-CoV-2 KP.3.1.1 Spike Protein To Be Published

9ELP

Cryo-EM structure of SARS-CoV-2 Omicron JN.1.11.1+S31 deletion spike protein (one RBD up state)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
Authors:	Feng, Z, Huang, J, Ward, A.B.
Deposit date:	2024-12-04
Release date:	2025-05-28
Method:	ELECTRON MICROSCOPY (2.94 Å)
Cite:	Structure of SARS-CoV-2 KP.3.1.1 Spike Protein To Be Published

9ELQ

Cryo-EM structure of SARS-CoV-2 Omicron JN.1.11.1+S31 deletion spike protein (closed state)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
Authors:	Feng, Z, Huang, J, Ward, A.B.
Deposit date:	2024-12-04
Release date:	2025-05-28
Method:	ELECTRON MICROSCOPY (2.64 Å)
Cite:	Structure of SARS-CoV-2 KP.3.1.1 Spike Protein To Be Published

9HH5

Crystal Structure of nsp15 Endoribonuclease from SARS CoV-2 in Complex with Sepantronium (YM-155)
Descriptor:	1-(2-methoxyethyl)-2-methyl-3-(pyrazin-2-ylmethyl)benzo[f]benzimidazol-3-ium-4,9-dione, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Nsp15 - Uridylate-specific endoribonuclease, ...
Authors:	Chatziefthymiou, S.D, Kolbe, M, Hakanpaeae, J, Labahn, J, Windshuegel, B.
Deposit date:	2024-11-21
Release date:	2025-05-28
Method:	X-RAY DIFFRACTION (2.08 Å)
Cite:	Identification, validation, and characterization of approved and investigational drugs interfering with the SARS-CoV-2 endoribonuclease Nsp15. Protein Sci., 34, 2025

9HH6

Crystal Structure of Nsp15 Endoribonuclease from SARS CoV-2 in Complex with TAS-103
Descriptor:	1,2-ETHANEDIOL, 6-[2-(dimethylamino)ethylamino]-3-oxidanyl-indeno[2,1-c]quinolin-7-one, ORF1ab polyprotein, ...
Authors:	Chatziefthymiou, S.D, Kolbe, M, Hakanpaeae, J, Labahn, J, Windshuegel, B.
Deposit date:	2024-11-21
Release date:	2025-05-28
Method:	SOLUTION SCATTERING (2 Å), X-RAY DIFFRACTION
Cite:	Identification, validation, and characterization of approved and investigational drugs interfering with the SARS-CoV-2 endoribonuclease Nsp15. Protein Sci., 34, 2025

9IZB

Crystal structure of SARS-CoV-2 main protease in complex with TMP1
Descriptor:	3C-like proteinase nsp5, TMP1
Authors:	Deng, X.Y, Zeng, R, Yang, S.Y, Lei, J.
Deposit date:	2024-08-01
Release date:	2025-05-28
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Crystal structure of SARS-CoV-2 main protease in complex with TMP1 To Be Published

9ELJ

Cryo-EM structure of SARS-CoV-2 Omicron JN.1.11+Q493E+S31deletion spike protein (one RBD up state)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
Authors:	Feng, Z, Huang, J, Ward, A.B.
Deposit date:	2024-12-04
Release date:	2025-06-04
Method:	ELECTRON MICROSCOPY (2.92 Å)
Cite:	Structure of SARS-CoV-2 KP.3.1.1 Spike Protein To Be Published

9ELK

Cryo-EM structure of SARS-CoV-2 Omicron JN.1.11+Q493E+S31deletion spike protein (closed state)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
Authors:	Feng, Z, Huang, J, Ward, A.B.
Deposit date:	2024-12-04
Release date:	2025-06-04
Method:	ELECTRON MICROSCOPY (2.82 Å)
Cite:	Structure of SARS-CoV-2 KP.3.1.1 Spike Protein To Be Published

9ELL

Cryo-EM structure of SARS-CoV-2 Omicron JN.1.11 spike protein (one RBD up state)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
Authors:	Feng, Z, Huang, J, Ward, A.B.
Deposit date:	2024-12-04
Release date:	2025-06-04
Method:	ELECTRON MICROSCOPY (2.93 Å)
Cite:	Structure of SARS-CoV-2 KP.3.1.1 Spike Protein To Be Published

9ELM

Cryo-EM structure of SARS-CoV-2 Omicron JN.1.11 spike protein (closed state)
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
Authors:	Feng, Z, Huang, J, Ward, A.B.
Deposit date:	2024-12-04
Release date:	2025-06-04
Method:	ELECTRON MICROSCOPY (2.68 Å)
Cite:	Structure of SARS-CoV-2 KP.3.1.1 Spike Protein To Be Published

9ML4

Structure of the SARS-CoV-2 Spike 6P in complex with the rabbit M8b-A10 Fab
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, M8b-A10 heavy chain, M8b-A10 light chain, ...
Authors:	Fan, C, Bjorkman, P.J.
Deposit date:	2024-12-18
Release date:	2025-06-04
Method:	ELECTRON MICROSCOPY (3.3 Å)
Cite:	Cross-reactive sarbecovirus antibodies induced by mosaic RBD nanoparticles. Proc.Natl.Acad.Sci.USA, 122, 2025

9ML5

Structure of the SARS-CoV-2 Spike 6P in complex with the rabbit M8b-B8 Fab
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, M8b-B8 heavy chain, ...
Authors:	Fan, C, Bjorkman, P.J.
Deposit date:	2024-12-18
Release date:	2025-06-04
Method:	ELECTRON MICROSCOPY (3.4 Å)
Cite:	Cross-reactive sarbecovirus antibodies induced by mosaic RBD nanoparticles. Proc.Natl.Acad.Sci.USA, 122, 2025

9ML6

Structure of the SARS-CoV-2 Spike 6P in complex with the rabbit M8b-C9 Fab
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, M8b-C9 heavy chain, M8b-C9 light chain, ...
Authors:	Fan, C, Bjorkman, P.J.
Deposit date:	2024-12-18
Release date:	2025-06-04
Method:	ELECTRON MICROSCOPY (3.5 Å)
Cite:	Cross-reactive sarbecovirus antibodies induced by mosaic RBD nanoparticles. Proc.Natl.Acad.Sci.USA, 122, 2025

9ML7

Structure of the SARS-CoV-2 Spike 6P in complex with the rabbit M8b-C10 Fab
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, M8b-C10 heavy chain, ...
Authors:	Fan, C, Bjorkman, P.J.
Deposit date:	2024-12-18
Release date:	2025-06-04
Method:	ELECTRON MICROSCOPY (3.2 Å)
Cite:	Cross-reactive sarbecovirus antibodies induced by mosaic RBD nanoparticles. Proc.Natl.Acad.Sci.USA, 122, 2025

9ML8

Crystal structure of the SARS-CoV-2 RBD in complex with the rabbit M8b-B1 Fab
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, M8b-B1 heavy chain, M8b-B1 light chain, ...
Authors:	Fan, C, Bjorkman, P.J.
Deposit date:	2024-12-18
Release date:	2025-06-04
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Cross-reactive sarbecovirus antibodies induced by mosaic RBD nanoparticles. Proc.Natl.Acad.Sci.USA, 122, 2025

9ML9

Crystal structure of the SARS-CoV-2 RBD in complex with the rabbit M8b-C9 Fab
Descriptor:	2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, M8b-C9 heavy chain, ...
Authors:	Fan, C, Bjorkman, P.J.
Deposit date:	2024-12-18
Release date:	2025-06-04
Method:	X-RAY DIFFRACTION (2.59 Å)
Cite:	Cross-reactive sarbecovirus antibodies induced by mosaic RBD nanoparticles. Proc.Natl.Acad.Sci.USA, 122, 2025

9MRU

Structural Asymmetry in SARS-CoV-2 Nsp15 Hexamer Important for Catalytic Activity
Descriptor:	Uridylate-specific endoribonuclease nsp15
Authors:	Ketawala, G.K, Sonowal, M, Schrag, L, Fromme, R, Botha, S, Fromme, P.
Deposit date:	2025-01-08
Release date:	2025-06-04
Method:	X-RAY DIFFRACTION (3 Å)
Cite:	Structural Asymmetry in SARS-CoV-2 Nsp15 Hexamer Important for Catalytic Activity To Be Published

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