8KEO
 
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8KEP
 
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8KEQ
 
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8KER
 
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8TQU
 
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9FJK
 
 | Omicron BA.1 Spike protein with neutralizing NTD specific mAb K501SP6 | 分子名称: | K501SP6 Fv Heavy Chain, K501SP6 Fv Light Chain, Spike glycoprotein,Fibritin | 著者 | Bjoernsson, K.H, Walker, M.R, Raghavan, S.S.R, Ward, A.B, Barfod, L.K. | 登録日 | 2024-05-31 | 公開日 | 2024-08-14 | 最終更新日 | 2025-07-02 | 実験手法 | ELECTRON MICROSCOPY (2.84 Å) | 主引用文献 | Broadly potent spike-specific human monoclonal antibodies inhibit SARS-CoV-2 Omicron sub-lineages. Commun Biol, 7, 2024
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8UPX
 
 | Omicron-S-MERS-RBD | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,SARS-CoV-2 omicron spike with MERS RBD | 著者 | Bu, F, Li, F, Liu, B. | 登録日 | 2023-10-23 | 公開日 | 2024-08-21 | 最終更新日 | 2024-10-30 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Pan-beta-coronavirus subunit vaccine prevents SARS-CoV-2 Omicron, SARS-CoV, and MERS-CoV challenge. J.Virol., 98, 2024
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8YE4
 
 | The complex of TCR NYN-I and HLA-A24 bound to SARS-CoV-2 Spike448-456 peptide NYNYLYRLF | 分子名称: | Beta-2-microglobulin, MHC class I antigen precusor, Spike protein S1, ... | 著者 | Deng, S.S, Jin, T.C, Xu, Z.H, Wang, M.H. | 登録日 | 2024-02-21 | 公開日 | 2024-08-21 | 最終更新日 | 2024-10-23 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structural insights into immune escape at killer T cell epitope by SARS-CoV-2 Spike Y453F variants. J.Biol.Chem., 300, 2024
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8ZHE
 
 | SARS-CoV-2 spike trimer (6P) in complex with three R1-26 Fabs | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of R1-26 Fab, ... | 著者 | Yan, Q, Gao, X, Liu, B, Hou, R, He, P, Li, Z, Chen, Q, Wang, J, He, J, Chen, L, Zhao, J, Xiong, X. | 登録日 | 2024-05-10 | 公開日 | 2024-08-21 | 最終更新日 | 2024-10-23 | 実験手法 | ELECTRON MICROSCOPY (3.16 Å) | 主引用文献 | Antibodies utilizing VL6-57 light chains target a convergent cryptic epitope on SARS-CoV-2 spike protein and potentially drive the genesis of Omicron variants. Nat Commun, 15, 2024
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8ZHG
 
 | SARS-CoV-2 spike trimer (6P) in complex with R1-26 Fab, focused refinement of RBD-Fab region | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of R1-26 Fab, Light chain of R1-26 Fab, ... | 著者 | Yan, Q, Gao, X, Liu, B, Hou, R, He, P, Li, Z, Chen, Q, Wang, J, He, J, Chen, L, Zhao, J, Xiong, X. | 登録日 | 2024-05-10 | 公開日 | 2024-08-21 | 最終更新日 | 2024-10-30 | 実験手法 | ELECTRON MICROSCOPY (3.51 Å) | 主引用文献 | Antibodies utilizing VL6-57 light chains target a convergent cryptic epitope on SARS-CoV-2 spike protein and potentially drive the genesis of Omicron variants. Nat Commun, 15, 2024
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8ZHH
 
 | SARS-CoV-2 spike trimer (6P) in complex with two H18 Fabs | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of H18 Fab, ... | 著者 | Yan, Q, Gao, X, Liu, B, Hou, R, He, P, Li, Z, Chen, Q, Wang, J, He, J, Chen, L, Zhao, J, Xiong, X. | 登録日 | 2024-05-10 | 公開日 | 2024-08-21 | 最終更新日 | 2024-11-20 | 実験手法 | ELECTRON MICROSCOPY (5.55 Å) | 主引用文献 | Antibodies utilizing VL6-57 light chains target a convergent cryptic epitope on SARS-CoV-2 spike protein and potentially drive the genesis of Omicron variants. Nat Commun, 15, 2024
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8ZHM
 
 | SARS-CoV-2 spike trimer (6P) in complex with three H18 and three R1-32 Fabs | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of H18 Fab, ... | 著者 | Yan, Q, Gao, X, Liu, B, Hou, R, He, P, Li, Z, Chen, Q, Wang, J, He, J, Chen, L, Zhao, J, Xiong, X. | 登録日 | 2024-05-11 | 公開日 | 2024-08-21 | 最終更新日 | 2024-10-23 | 実験手法 | ELECTRON MICROSCOPY (3.39 Å) | 主引用文献 | Antibodies utilizing VL6-57 light chains target a convergent cryptic epitope on SARS-CoV-2 spike protein and potentially drive the genesis of Omicron variants. Nat Commun, 15, 2024
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8ZHO
 
 | SARS-CoV-2 S1 in complex with H18 and R1-32 Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of H18 Fab, Heavy chain of R1-32 Fab, ... | 著者 | Yan, Q, Gao, X, Liu, B, Hou, R, He, P, Li, Z, Chen, Q, Wang, J, He, J, Chen, L, Zhao, J, Xiong, X. | 登録日 | 2024-05-11 | 公開日 | 2024-08-21 | 最終更新日 | 2024-10-23 | 実験手法 | ELECTRON MICROSCOPY (3.54 Å) | 主引用文献 | Antibodies utilizing VL6-57 light chains target a convergent cryptic epitope on SARS-CoV-2 spike protein and potentially drive the genesis of Omicron variants. Nat Commun, 15, 2024
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8ZV9
 
 | Complex structure of HLA2402 with recognizing SARS-CoV-2 Y453F epitope NYNYLFRLF | 分子名称: | 1,2-ETHANEDIOL, Beta-2-microglobulin, MHC class I antigen, ... | 著者 | Deng, S.S, Jin, T.C, Xu, Z.H, Wang, M.H. | 登録日 | 2024-06-11 | 公開日 | 2024-08-21 | 最終更新日 | 2024-11-13 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural insights into immune escape at killer T cell epitope by SARS-CoV-2 Spike Y453F variants. J.Biol.Chem., 300, 2024
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9F9Y
 
 | SARS-CoV-2 BA-2.87.1 Spike ectodomain | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,Fibritin | 著者 | Ren, J, Stuart, D.I, Duyvesteyn, H.M.E. | 登録日 | 2024-05-09 | 公開日 | 2024-08-21 | 最終更新日 | 2024-10-16 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Concerted deletions eliminate a neutralizing supersite in SARS-CoV-2 BA.2.87.1 spike. Structure, 32, 2024
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8UG9
 
 | XBB.1.5 spike/Nb5 complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nanosota-5, ... | 著者 | Ye, G, Bu, F, Liu, B, Li, F. | 登録日 | 2023-10-05 | 公開日 | 2024-08-28 | 最終更新日 | 2024-11-20 | 実験手法 | ELECTRON MICROSCOPY (3.49 Å) | 主引用文献 | Dual-role epitope on SARS-CoV-2 spike enhances and neutralizes viral entry across different variants. Plos Pathog., 20, 2024
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9FEH
 
 | Crystal structure of SARS-CoV-2 nsp14 methyltransferase domain in complex with the STM957 inhibitor | 分子名称: | Transcription factor ETV6,Guanine-N7 methyltransferase nsp14, ZINC ION, ~{N}-[[(2~{R},3~{S},4~{R},5~{R})-5-[4-azanyl-5-(2-pyridin-3-ylethynyl)pyrrolo[2,3-d]pyrimidin-7-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl]-3-cyano-~{N}-ethyl-4-methoxy-benzenesulfonamide | 著者 | Zilecka, E, Klima, M, Boura, E. | 登録日 | 2024-05-20 | 公開日 | 2024-08-28 | 最終更新日 | 2024-09-04 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Structure of SARS-CoV-2 MTase nsp14 with the inhibitor STM957 reveals inhibition mechanism that is shared with a poxviral MTase VP39. J Struct Biol X, 10, 2024
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8KEH
 
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8Y4C
 
 | BA.2.86 S-trimer in complex with Nab XGv280 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, XGv280 Heavy chain, ... | 著者 | Zhu, Q, Liu, P. | 登録日 | 2024-01-30 | 公開日 | 2024-09-04 | 最終更新日 | 2024-11-06 | 実験手法 | ELECTRON MICROSCOPY (3.75 Å) | 主引用文献 | Enhancing RBD exposure and S1 shedding by an extremely conserved SARS-CoV-2 NTD epitope. Signal Transduct Target Ther, 9, 2024
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8ZER
 
 | Crystal structure of the complex of Wuhan SARS-CoV-2 RBD (319-541) with P2C5 nanobody | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody P2C5, Spike protein S1, ... | 著者 | Sluchanko, N.N, Varfolomeeva, L.A, Shcheblyakov, D.V, Logunov, D.Y, Gintsburg, A.L, Popov, V.O, Boyko, K.M. | 登録日 | 2024-05-06 | 公開日 | 2024-09-04 | 最終更新日 | 2024-11-06 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structural Basis for Evasion of New SARS-CoV-2 Variants from the Potent Virus-Neutralizing Nanobody Targeting the S-Protein Receptor-Binding Domain. Biochemistry Mosc., 89, 2024
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8ZES
 
 | Crystal structure of the Wuhan SARS-CoV-2 RBD (333-541) complexed with P2C5 nanobody | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody P2C5, ... | 著者 | Sluchanko, N.N, Varfolomeeva, L.A, Shcheblyakov, D.V, Logunov, D.Y, Gintsburg, A.L, Popov, V.O, Boyko, K.M. | 登録日 | 2024-05-06 | 公開日 | 2024-09-04 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | 主引用文献 | Structural Basis for Evasion of New SARS-CoV-2 Variants from the Potent Virus-Neutralizing Nanobody Targeting the S-Protein Receptor-Binding Domain. Biochemistry Mosc., 89, 2024
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9EO6
 
 | SARS-CoV2 major protease in complex with a covalent inhibitor SLL11. | 分子名称: | 3C-like proteinase nsp5, Inhibitor SLL11, POTASSIUM ION | 著者 | Moche, M, Lennerstrand, J, Nyman, T, Strandback, E, Akaberi, D. | 登録日 | 2024-03-14 | 公開日 | 2024-09-04 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | 主引用文献 | Identification of novel and potent inhibitors of SARS-CoV-2 main protease from DNA-encoded chemical libraries. Antimicrob.Agents Chemother., 68, 2024
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9EOR
 
 | SARS-CoV2 major protease in complex with a covalent inhibitor SLL12. | 分子名称: | 3C-like proteinase nsp5, Inhibitor SLL12, POTASSIUM ION | 著者 | Moche, M, Lennerstrand, J, Nyman, T, Strandback, E, Akaberi, D. | 登録日 | 2024-03-15 | 公開日 | 2024-09-04 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Identification of novel and potent inhibitors of SARS-CoV-2 main protease from DNA-encoded chemical libraries. Antimicrob.Agents Chemother., 68, 2024
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9EOX
 
 | SARS-CoV2 major protease in covalent complex with a soluble inhibitor. | 分子名称: | 3C-like proteinase nsp5, POTASSIUM ION, Soluble inhibitor | 著者 | Moche, M, Lennerstrand, J, Nyman, T, Strandback, E, Akaberi, D. | 登録日 | 2024-03-15 | 公開日 | 2024-09-04 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | 主引用文献 | Identification of novel and potent inhibitors of SARS-CoV-2 main protease from DNA-encoded chemical libraries. Antimicrob.Agents Chemother., 68, 2024
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8Y4A
 
 | BA.2.86 S-trimer in complex with Nab XG2v046 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | 著者 | Zhu, Q, Liu, P. | 登録日 | 2024-01-30 | 公開日 | 2024-09-11 | 最終更新日 | 2024-10-09 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Enhancing RBD exposure and S1 shedding by an extremely conserved SARS-CoV-2 NTD epitope. Signal Transduct Target Ther, 9, 2024
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