HLA class II histocompatibility antigen, DR alpha chain
MHC class II antigen
Keywords
MEMBRANE PROTEIN / HLA / MHC class II / Glycoprotein / Immune response / Membrane / MHC II / Transmembrane / Elongation factor / GTP-binding / Methylation / Nucleotide-binding / Nucleus / Phosphoprotein / Protein biosynthesis
Function / homology
Function and homology information
cytoplasmic side of lysosomal membrane / Eukaryotic Translation Elongation / : / eukaryotic translation elongation factor 1 complex / regulation of chaperone-mediated autophagy / myeloid dendritic cell antigen processing and presentation / antigen processing and presentation of endogenous peptide antigen via MHC class II / autolysosome membrane / regulation of T-helper cell differentiation / positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation ...cytoplasmic side of lysosomal membrane / Eukaryotic Translation Elongation / : / eukaryotic translation elongation factor 1 complex / regulation of chaperone-mediated autophagy / myeloid dendritic cell antigen processing and presentation / antigen processing and presentation of endogenous peptide antigen via MHC class II / autolysosome membrane / regulation of T-helper cell differentiation / positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation / translation factor activity, RNA binding / MHC class II receptor activity / positive regulation of CD4-positive, alpha-beta T cell activation / antigen processing and presentation of peptide or polysaccharide antigen via MHC class II / positive regulation of memory T cell differentiation / transport vesicle membrane / polysaccharide binding / positive regulation of lipid kinase activity / Translocation of ZAP-70 to Immunological synapse / Phosphorylation of CD3 and TCR zeta chains / plasma membrane => GO:0005886 / translational elongation / Generation of second messenger molecules / immunological synapse / PD-1 signaling / translation elongation factor activity / T cell receptor binding / type II interferon-mediated signaling pathway / MHC class II antigen presentation / trans-Golgi network membrane / clathrin-coated endocytic vesicle membrane / lumenal side of endoplasmic reticulum membrane / ER to Golgi transport vesicle membrane / cognition / peptide antigen assembly with MHC class II protein complex / MHC class II protein complex / positive regulation of T cell mediated cytotoxicity / peptide antigen binding / antigen processing and presentation of exogenous peptide antigen via MHC class II / endocytic vesicle membrane / Interferon gamma signaling / positive regulation of immune response / positive regulation of T cell activation / Downstream TCR signaling / MHC class II protein complex binding / early endosome membrane / late endosome membrane / T cell receptor signaling pathway / adaptive immune response / endosome membrane / lysosome / translation / immune response / positive regulation of apoptotic process / Golgi membrane / lysosomal membrane / GTPase activity / synapse / GTP binding / protein kinase binding / cell surface / signal transduction / extracellular exosome / membrane / plasma membrane / cytoplasm Similarity search - Function
Translation elongation factor EF1A, eukaryotic/archaeal / : / Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1 / Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1 / MHC class II, beta chain, N-terminal / Class II histocompatibility antigen, beta domain / Class II histocompatibility antigen, beta domain / Translation elongation factor EFTu/EF1A, C-terminal / Elongation factor Tu C-terminal domain / MHC class II, alpha chain, N-terminal ...Translation elongation factor EF1A, eukaryotic/archaeal / : / Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1 / Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1 / MHC class II, beta chain, N-terminal / Class II histocompatibility antigen, beta domain / Class II histocompatibility antigen, beta domain / Translation elongation factor EFTu/EF1A, C-terminal / Elongation factor Tu C-terminal domain / MHC class II, alpha chain, N-terminal / Class II histocompatibility antigen, alpha domain / Class II histocompatibility antigen, alpha domain / MHC class II, alpha/beta chain, N-terminal / Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal / Tr-type G domain, conserved site / Translational (tr)-type guanine nucleotide-binding (G) domain signature. / Translation elongation factor EFTu-like, domain 2 / Elongation factor Tu domain 2 / Translational (tr)-type GTP-binding domain / Elongation factor Tu GTP binding domain / Translational (tr)-type guanine nucleotide-binding (G) domain profile. / MHC classes I/II-like antigen recognition protein / : / Immunoglobulin/major histocompatibility complex, conserved site / Immunoglobulins and major histocompatibility complex proteins signature. / Immunoglobulin C-Type / Immunoglobulin C1-set / Immunoglobulin C1-set domain / Translation protein, beta-barrel domain superfamily / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulins / Roll / Immunoglobulin-like fold / Immunoglobulin-like / Sandwich / P-loop containing nucleoside triphosphate hydrolase / Mainly Beta / Alpha Beta Similarity search - Domain/homology
MHC class II antigen / HLA class II histocompatibility antigen, DR alpha chain / Elongation factor 1-alpha 2 / HLA class II histocompatibility antigen, DR beta 3 chain Similarity search - Component
Biological species
Homo sapiens (human)
Method
X-RAY DIFFRACTION / SYNCHROTRON / Resolution: 1.8 Å
Mass: 18.015 Da / Num. of mol.: 454 / Source method: isolated from a natural source / Formula: H2O
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Details
Sequence details
CHAIN C AND CHAIN B ARE FUSED TOGETHER THROUGH A LINKER ( GGGGSLVPRGSGGGGS ). HOWEVER THIS LINKER ...CHAIN C AND CHAIN B ARE FUSED TOGETHER THROUGH A LINKER ( GGGGSLVPRGSGGGGS ). HOWEVER THIS LINKER IS DISORDERED
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Experimental details
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Experiment
Experiment
Method: X-RAY DIFFRACTION / Number of used crystals: 1
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Sample preparation
Crystal
Density Matthews: 2.59 Å3/Da / Density % sol: 52.51 %
Crystal grow
Temperature: 298 K / Method: vapor diffusion, hanging drop / pH: 7.5 Details: 1.6 M ammonium sulfate, pH 7.5, vapor diffusion, hanging drop, temperature 298K
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