[English] 日本語
Yorodumi- PDB-1shc: SHC PTB DOMAIN COMPLEXED WITH A TRKA RECEPTOR PHOSPHOPEPTIDE, NMR... -
+Open data
-Basic information
Entry | Database: PDB / ID: 1shc | ||||||
---|---|---|---|---|---|---|---|
Title | SHC PTB DOMAIN COMPLEXED WITH A TRKA RECEPTOR PHOSPHOPEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE | ||||||
Components |
| ||||||
Keywords | COMPLEX (SIGNAL TRANSDUCTION/PEPTIDE) / COMPLEX (SIGNAL TRANSDUCTION-PEPTIDE) / PHOSPHOTYROSINE BINDING DOMAIN (PTB) / COMPLEX (SIGNAL TRANSDUCTION-PEPTIDE) complex | ||||||
Function / homology | Function and homology information Shc-EGFR complex / regulation of superoxide metabolic process / epidermal growth factor binding / positive regulation of cell proliferation in bone marrow / behavioral response to formalin induced pain / neurotrophin p75 receptor binding / olfactory nerve development / response to hydrostatic pressure / TRKA activation by NGF / PLC-gamma1 signalling ...Shc-EGFR complex / regulation of superoxide metabolic process / epidermal growth factor binding / positive regulation of cell proliferation in bone marrow / behavioral response to formalin induced pain / neurotrophin p75 receptor binding / olfactory nerve development / response to hydrostatic pressure / TRKA activation by NGF / PLC-gamma1 signalling / Signalling to STAT3 / programmed cell death involved in cell development / neurotrophin receptor activity / mechanoreceptor differentiation / nerve growth factor receptor activity / neurotrophin binding / Sertoli cell development / axonogenesis involved in innervation / GPI-linked ephrin receptor activity / nerve growth factor signaling pathway / Retrograde neurotrophin signalling / XBP1(S) activates chaperone genes / nerve growth factor binding / NGF-independant TRKA activation / sympathetic nervous system development / Signalling to p38 via RIT and RIN / neurotrophin TRKA receptor binding / ARMS-mediated activation / transmembrane receptor protein tyrosine kinase adaptor activity / Interleukin-15 signaling / positive regulation of Ras protein signal transduction / positive regulation of programmed cell death / positive regulation of synapse assembly / Interleukin-2 signaling / Signaling by LTK / PI3K/AKT activation / epidermal growth factor receptor binding / Signaling by ALK / Frs2-mediated activation / peptidyl-tyrosine autophosphorylation / detection of temperature stimulus involved in sensory perception of pain / neurotrophin TRK receptor signaling pathway / RET signaling / Activated NTRK3 signals through RAS / Activated NTRK2 signals through RAS / Interleukin-3, Interleukin-5 and GM-CSF signaling / SHC1 events in ERBB4 signaling / SHC1 events in EGFR signaling / response to axon injury / Signalling to RAS / neuron development / SHC-related events triggered by IGF1R / transmembrane receptor protein tyrosine kinase activity / Role of LAT2/NTAL/LAB on calcium mobilization / Interleukin receptor SHC signaling / Signal attenuation / SHC1 events in ERBB2 signaling / SHC-mediated cascade:FGFR3 / MET activates RAS signaling / positive regulation of synaptic transmission, glutamatergic / detection of mechanical stimulus involved in sensory perception of pain / negative regulation of angiogenesis / SHC-mediated cascade:FGFR2 / SHC-mediated cascade:FGFR4 / Erythropoietin activates RAS / SHC-mediated cascade:FGFR1 / response to electrical stimulus / Signaling by CSF3 (G-CSF) / Tie2 Signaling / insulin-like growth factor receptor binding / ephrin receptor binding / phosphotyrosine residue binding / Integrin signaling / Constitutive Signaling by Overexpressed ERBB2 / FCERI mediated Ca+2 mobilization / Insulin receptor signalling cascade / response to nutrient levels / B cell differentiation / insulin-like growth factor receptor signaling pathway / Signaling by ERBB2 TMD/JMD mutants / cellular response to nerve growth factor stimulus / positive regulation of GTPase activity / Constitutive Signaling by EGFRvIII / Signaling by ERBB2 ECD mutants / axon guidance / Signaling by ERBB2 KD Mutants / epidermal growth factor receptor signaling pathway / receptor protein-tyrosine kinase / FCERI mediated MAPK activation / kinase binding / cell-cell adhesion / insulin receptor binding / circadian rhythm / peptidyl-tyrosine phosphorylation / phospholipid binding / receptor tyrosine kinase binding / cellular response to growth factor stimulus / positive regulation of neuron projection development / cellular response to nicotine / recycling endosome membrane Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | SOLUTION NMR | ||||||
Authors | Zhou, M.-M. / Ravichandran, K.S. / Olejniczak, E.T. / Petros, A.M. / Meadows, R.P. / Sattler, M. / Harlan, J.E. / Wade, W.S. / Burakoff, S.J. / Fesik, S.W. | ||||||
Citation | Journal: Nature / Year: 1995 Title: Structure and ligand recognition of the phosphotyrosine binding domain of Shc. Authors: Zhou, M.M. / Ravichandran, K.S. / Olejniczak, E.F. / Petros, A.M. / Meadows, R.P. / Sattler, M. / Harlan, J.E. / Wade, W.S. / Burakoff, S.J. / Fesik, S.W. #1: Journal: Nat.Struct.Biol. / Year: 1996 Title: Structural Basis for Il-4 Receptor Phosphopeptide Recognition by the Irs-1 Ptb Domain Authors: Zhou, M.M. / Huang, B. / Olejniczak, E.T. / Meadows, R.P. / Shuker, S.B. / Miyazaki, M. / Trub, T. / Shoelson, S.E. / Fesik, S.W. #2: Journal: J.Biol.Chem. / Year: 1995 Title: Specificity of the Ptb Domain of Shc for Beta Turn-Forming Pentapeptide Motifs Amino-Terminal to Phosphotyrosine Authors: Trub, T. / Choi, W.E. / Wolf, G. / Ottinger, E. / Chen, Y. / Weiss, M. / Shoelson, S.E. #3: Journal: Science / Year: 1994 Title: An Alternative to Sh2 Domains for Binding Tyrosine-Phosphorylated Proteins Authors: Kavanaugh, W.M. / Williams, L.T. | ||||||
History |
|
-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
---|
-Downloads & links
-Download
PDBx/mmCIF format | 1shc.cif.gz | 80.6 KB | Display | PDBx/mmCIF format |
---|---|---|---|---|
PDB format | pdb1shc.ent.gz | 64.9 KB | Display | PDB format |
PDBx/mmJSON format | 1shc.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 1shc_validation.pdf.gz | 261.6 KB | Display | wwPDB validaton report |
---|---|---|---|---|
Full document | 1shc_full_validation.pdf.gz | 261.4 KB | Display | |
Data in XML | 1shc_validation.xml.gz | 7.5 KB | Display | |
Data in CIF | 1shc_validation.cif.gz | 9.6 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/sh/1shc ftp://data.pdbj.org/pub/pdb/validation_reports/sh/1shc | HTTPS FTP |
-Related structure data
Similar structure data |
---|
-Links
-Assembly
Deposited unit |
| |||||||||
---|---|---|---|---|---|---|---|---|---|---|
1 |
| |||||||||
NMR ensembles |
|
-Components
#1: Protein | Mass: 21409.584 Da / Num. of mol.: 1 / Fragment: PTB DOMAIN Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Strain: BL21 (DE3) / Cell line: BL21 / Gene: PTB DOMAIN OF SHC / Plasmid: PET15B / Gene (production host): PTB DOMAIN OF SHC / Production host: Escherichia coli (E. coli) / References: UniProt: P29353 |
---|---|
#2: Protein/peptide | Mass: 1514.508 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source References: UniProt: P04629 |
-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR |
---|
-Sample preparation
Crystal grow | *PLUS Method: other / Details: NMR |
---|
-Processing
Software |
| ||||||||
---|---|---|---|---|---|---|---|---|---|
NMR software | Name: X-PLOR / Developer: BRUNGER / Classification: refinement | ||||||||
Refinement | Software ordinal: 1 Details: SET OF IDEAL BOND LENGTHS AND ANGLES WERE USED DURING REFINEMENT: PARALLHDG.PRO IN X-PLOR. | ||||||||
NMR ensemble | Conformers submitted total number: 1 |