- PDB-4lsq: Crystal structure of broadly and potently neutralizing antibody V... -
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基本情報
登録情報
データベース: PDB / ID: 4lsq
タイトル
Crystal structure of broadly and potently neutralizing antibody VRC-CH31 in complex with HIV-1 clade A/E gp120 93TH057 with LOOP D and Loop V5 from clade A strain 3415_v1_c1
要素
ENVELOPE GLYCOPROTEIN GP120 WITH LOOP D AND V5 FROM STRAIN 3415_V1_C1
HEAVY CHAIN OF ANTIBODY VRC-CH31
LIGHT CHAIN OF ANTIBODY VRC-CH31 WITH N70D MUTATION
キーワード
viral protein/immune system (ウイルス性) / Neutralizing antibody VRC-CH31 / viral protein-immune system complex (ウイルス性)
機能・相同性
機能・相同性情報
positive regulation of plasma membrane raft polarization / positive regulation of receptor clustering / positive regulation of establishment of T cell polarity / virus-mediated perturbation of host defense response / host cell endosome membrane / clathrin-dependent endocytosis of virus by host cell / viral protein processing / fusion of virus membrane with host plasma membrane / fusion of virus membrane with host endosome membrane / エンベロープ (ウイルス) ...positive regulation of plasma membrane raft polarization / positive regulation of receptor clustering / positive regulation of establishment of T cell polarity / virus-mediated perturbation of host defense response / host cell endosome membrane / clathrin-dependent endocytosis of virus by host cell / viral protein processing / fusion of virus membrane with host plasma membrane / fusion of virus membrane with host endosome membrane / エンベロープ (ウイルス) / virion attachment to host cell / host cell plasma membrane / virion membrane / structural molecule activity / 細胞膜 類似検索 - 分子機能
HIV Envelope Protein Gp120; Chain G / Human immunodeficiency virus 1, Gp160, envelope glycoprotein / Envelope glycoprotein Gp160 / Retroviral envelope protein / Retroviral envelope protein GP41-like / Gp120 core superfamily / Gp120 (HIV) / Human immunodeficiency virus 1, envelope glycoprotein Gp120 / Beta Complex / 抗体 ...HIV Envelope Protein Gp120; Chain G / Human immunodeficiency virus 1, Gp160, envelope glycoprotein / Envelope glycoprotein Gp160 / Retroviral envelope protein / Retroviral envelope protein GP41-like / Gp120 core superfamily / Gp120 (HIV) / Human immunodeficiency virus 1, envelope glycoprotein Gp120 / Beta Complex / 抗体 / Immunoglobulin-like / サンドイッチ / Mainly Beta 類似検索 - ドメイン・相同性
G: ENVELOPE GLYCOPROTEIN GP120 WITH LOOP D AND V5 FROM STRAIN 3415_V1_C1 H: HEAVY CHAIN OF ANTIBODY VRC-CH31 L: LIGHT CHAIN OF ANTIBODY VRC-CH31 WITH N70D MUTATION ヘテロ分子