登録情報 データベース : PDB / ID : 7voe 構造の表示 ダウンロードとリンクタイトル Crystal structure of 5-HT2AR in complex with aripiprazole 要素5-hydroxytryptamine receptor 2A,Soluble cytochrome b562 詳細 キーワード MEMBRANE PROTEIN / GPCR / Dopamine Receptor / serotonin receptor / aripiprazole / antipsychotic機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
positive regulation of heat generation / protein localization to cytoskeleton / 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding / Gq/11-coupled serotonin receptor activity / phospholipase C-activating serotonin receptor signaling pathway / positive regulation of phosphatidylinositol biosynthetic process / G protein-coupled serotonin receptor signaling pathway / G protein-coupled serotonin receptor complex / neurofilament / positive regulation of cytokine production involved in immune response ... positive regulation of heat generation / protein localization to cytoskeleton / 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding / Gq/11-coupled serotonin receptor activity / phospholipase C-activating serotonin receptor signaling pathway / positive regulation of phosphatidylinositol biosynthetic process / G protein-coupled serotonin receptor signaling pathway / G protein-coupled serotonin receptor complex / neurofilament / positive regulation of cytokine production involved in immune response / artery smooth muscle contraction / Serotonin receptors / cell body fiber / serotonin receptor signaling pathway / sensitization / urinary bladder smooth muscle contraction / serotonin binding / negative regulation of synaptic transmission, glutamatergic / G protein-coupled serotonin receptor activity / positive regulation of platelet aggregation / neurotransmitter receptor activity / temperature homeostasis / positive regulation of DNA biosynthetic process / regulation of dopamine secretion / protein tyrosine kinase activator activity / positive regulation of execution phase of apoptosis / negative regulation of potassium ion transport / detection of temperature stimulus involved in sensory perception of pain / behavioral response to cocaine / G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger / : / positive regulation of fat cell differentiation / detection of mechanical stimulus involved in sensory perception of pain / release of sequestered calcium ion into cytosol / positive regulation of vasoconstriction / presynaptic modulation of chemical synaptic transmission / phosphatidylinositol 3-kinase/protein kinase B signal transduction / positive regulation of glycolytic process / dendritic shaft / caveola / glycolytic process / electron transport chain / memory / intracellular calcium ion homeostasis / positive regulation of inflammatory response / positive regulation of peptidyl-tyrosine phosphorylation / positive regulation of neuron apoptotic process / virus receptor activity / presynaptic membrane / positive regulation of cytosolic calcium ion concentration / cytoplasmic vesicle / G alpha (q) signalling events / chemical synaptic transmission / postsynaptic membrane / periplasmic space / electron transfer activity / positive regulation of ERK1 and ERK2 cascade / response to xenobiotic stimulus / iron ion binding / axon / neuronal cell body / glutamatergic synapse / dendrite / heme binding / positive regulation of cell population proliferation / protein-containing complex binding / identical protein binding / plasma membrane 類似検索 - 分子機能 5-Hydroxytryptamine 2A receptor / 5-hydroxytryptamine receptor family / Cytochrome b562 / Cytochrome b562 / Cytochrome c/b562 / Serpentine type 7TM GPCR chemoreceptor Srsx / G-protein coupled receptors family 1 signature. / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family) 類似検索 - ドメイン・相同性 Chem-9SC / CHOLESTEROL / (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate / Soluble cytochrome b562 / 5-hydroxytryptamine receptor 2A 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.9 Å 詳細データ登録者 Chen, Z. / Fan, L. / Wang, H. / Yu, J. / Lu, D. / Qi, J. / Nie, F. / Luo, Z. / Liu, Z. / Cheng, J. / Wang, S. 資金援助 中国, 3件 詳細 詳細を隠す組織 認可番号 国 Chinese Academy of Sciences XDB19020111 中国 Ministry of Science and Technology (MoST, China) 2020YFA0509600 中国 National Natural Science Foundation of China (NSFC) 32071197 中国
引用ジャーナル : Nat.Neurosci. / 年 : 2022タイトル : Structure-based design of a novel third-generation antipsychotic drug lead with potential antidepressant properties.著者 : Chen, Z. / Fan, L. / Wang, H. / Yu, J. / Lu, D. / Qi, J. / Nie, F. / Luo, Z. / Liu, Z. / Cheng, J. / Wang, S. 履歴 登録 2021年10月13日 登録サイト : PDBJ / 処理サイト : PDBJ改定 1.0 2021年12月22日 Provider : repository / タイプ : Initial release改定 1.1 2021年12月29日 Group : Data collection / Structure summary / カテゴリ : diffrn / entity / Item : _diffrn.ambient_temp / _entity.pdbx_mutation改定 1.2 2022年2月16日 Group : Database references / カテゴリ : citation / citation_authorItem : _citation.journal_volume / _citation.page_first ... _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.year / _citation_author.identifier_ORCID 改定 1.3 2023年11月29日 Group : Data collection / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
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