Entry Database : PDB / ID : 6rz5 Structure visualization Downloads & linksTitle XFEL crystal structure of the human cysteinyl leukotriene receptor 1 in complex with zafirlukast ComponentsCysteinyl leukotriene receptor 1,Soluble cytochrome b562,Cysteinyl leukotriene receptor 1 Details Keywords MEMBRANE PROTEIN / GPCR / LCP / cysteinyl leukotriene / LTD4 / cyslt1 / cysltr1 / cyslt1r / asthma / zafirlukast / BRIL / sodium site / Cysteinyl Leukotriene Receptor 1 / XFEL / Serial Femtosecond Crystallography / SFXFunction / homology Function and homology informationFunction Domain/homology Component
cysteinyl leukotriene receptor activity / leukotriene receptor activity / Leukotriene receptors / LTC4-CYSLTR mediated IL4 production / respiratory gaseous exchange by respiratory system / G protein-coupled peptide receptor activity / inflammatory response to antigenic stimulus / neuropeptide signaling pathway / establishment of localization in cell / electron transport chain ... cysteinyl leukotriene receptor activity / leukotriene receptor activity / Leukotriene receptors / LTC4-CYSLTR mediated IL4 production / respiratory gaseous exchange by respiratory system / G protein-coupled peptide receptor activity / inflammatory response to antigenic stimulus / neuropeptide signaling pathway / establishment of localization in cell / electron transport chain / defense response / chemotaxis / calcium ion transport / positive regulation of cytosolic calcium ion concentration / G alpha (q) signalling events / Potential therapeutics for SARS / periplasmic space / electron transfer activity / cell surface receptor signaling pathway / iron ion binding / heme binding / membrane / plasma membrane Similarity search - Function Cysteinyl leukotriene receptor 1 / Cysteinyl leukotriene receptor / Cytochrome b562 / Cytochrome b562 / Cytochrome c/b562 / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family) Similarity search - Domain/homology OLEIC ACID / (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate / zafirlukast / Soluble cytochrome b562 / Cysteinyl leukotriene receptor 1 Similarity search - ComponentBiological species Homo sapiens (human)Escherichia coli (E. coli)Method X-RAY DIFFRACTION / FREE ELECTRON LASER / MOLECULAR REPLACEMENT / Resolution : 2.53 Å DetailsAuthors Luginina, A. / Gusach, A. / Marin, E. / Mishin, A. / Brouillette, R. / Popov, P. / Shiryaeva, A. / Besserer-Offroy, E. / Longpre, J.M. / Lyapina, E. ...Luginina, A. / Gusach, A. / Marin, E. / Mishin, A. / Brouillette, R. / Popov, P. / Shiryaeva, A. / Besserer-Offroy, E. / Longpre, J.M. / Lyapina, E. / Ishchenko, A. / Patel, N. / Polovinkin, V. / Safronova, N. / Bogorodskiy, A. / Edelweiss, E. / Liu, W. / Batyuk, A. / Gordeliy, V. / Han, G.W. / Sarret, P. / Katritch, V. / Borshchevskiy, V. / Cherezov, V. Funding support Russian Federation, United States, Canada, 3items Details Hide detailsOrganization Grant number Country Russian Science Foundation 16-14-10273 Russian Federation National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) R35 GM127086 United States Canadian Institutes of Health Research FDN-148413 Canada
CitationJournal : Sci Adv / Year : 2019Title : Structure-based mechanism of cysteinyl leukotriene receptor inhibition by antiasthmatic drugs.Authors: Luginina, A. / Gusach, A. / Marin, E. / Mishin, A. / Brouillette, R. / Popov, P. / Shiriaeva, A. / Besserer-Offroy, E. / Longpre, J.M. / Lyapina, E. / Ishchenko, A. / Patel, N. / Polovinkin, ... Authors : Luginina, A. / Gusach, A. / Marin, E. / Mishin, A. / Brouillette, R. / Popov, P. / Shiriaeva, A. / Besserer-Offroy, E. / Longpre, J.M. / Lyapina, E. / Ishchenko, A. / Patel, N. / Polovinkin, V. / Safronova, N. / Bogorodskiy, A. / Edelweiss, E. / Hu, H. / Weierstall, U. / Liu, W. / Batyuk, A. / Gordeliy, V. / Han, G.W. / Sarret, P. / Katritch, V. / Borshchevskiy, V. / Cherezov, V. History Deposition Jun 12, 2019 Deposition site : PDBE / Processing site : PDBERevision 1.0 Oct 30, 2019 Provider : repository / Type : Initial releaseRevision 2.0 Jan 15, 2020 Group : Advisory / Atomic model ... Advisory / Atomic model / Data collection / Database references / Derived calculations / Source and taxonomy / Structure summary Category : atom_site / atom_site_anisotrop ... atom_site / atom_site_anisotrop / entity_src_gen / pdbx_poly_seq_scheme / pdbx_unobs_or_zero_occ_atoms / pdbx_unobs_or_zero_occ_residues / pdbx_validate_torsion / struct_conf / struct_ref_seq / struct_ref_seq_dif Item : _atom_site.auth_seq_id / _atom_site_anisotrop.pdbx_auth_seq_id ... _atom_site.auth_seq_id / _atom_site_anisotrop.pdbx_auth_seq_id / _entity_src_gen.host_org_common_name / _pdbx_poly_seq_scheme.pdb_seq_num / _pdbx_unobs_or_zero_occ_atoms.auth_seq_id / _pdbx_unobs_or_zero_occ_residues.auth_seq_id / _pdbx_validate_torsion.auth_seq_id / _struct_conf.beg_auth_seq_id / _struct_conf.end_auth_seq_id / _struct_ref_seq.pdbx_auth_seq_align_beg / _struct_ref_seq.pdbx_auth_seq_align_end / _struct_ref_seq_dif.pdbx_auth_seq_num Revision 3.0 Apr 8, 2020 Group : Advisory / Atomic model ... Advisory / Atomic model / Data collection / Database references / Derived calculations / Structure summary Category : atom_site / atom_site_anisotrop ... atom_site / atom_site_anisotrop / pdbx_poly_seq_scheme / pdbx_struct_conn_angle / pdbx_unobs_or_zero_occ_atoms / pdbx_unobs_or_zero_occ_residues / pdbx_validate_torsion / struct_conf / struct_conn / struct_ref_seq / struct_ref_seq_dif Item : _atom_site.auth_seq_id / _atom_site_anisotrop.pdbx_auth_seq_id ... _atom_site.auth_seq_id / _atom_site_anisotrop.pdbx_auth_seq_id / _pdbx_poly_seq_scheme.pdb_seq_num / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_unobs_or_zero_occ_atoms.auth_seq_id / _pdbx_unobs_or_zero_occ_residues.auth_seq_id / _pdbx_validate_torsion.auth_seq_id / _struct_conf.beg_auth_seq_id / _struct_conf.end_auth_seq_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr2_auth_seq_id / _struct_ref_seq.pdbx_auth_seq_align_beg / _struct_ref_seq.pdbx_auth_seq_align_end / _struct_ref_seq_dif.pdbx_auth_seq_num Revision 3.1 Mar 30, 2022 Group : Author supporting evidence / Database references / Derived calculationsCategory : database_2 / pdbx_audit_support / struct_connItem : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_audit_support.funding_organization / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id Revision 3.2 Dec 13, 2023 Group : Data collection / Database referencesCategory : chem_comp_atom / chem_comp_bond / pdbx_related_exp_data_setRevision 3.3 Jan 24, 2024 Group : Refinement description / Category : pdbx_initial_refinement_model
Show all Show less