登録情報 | データベース: PDB / ID: 7me4 |
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タイトル | Structure of the extracellular WNT-binding module in Drosophila Ror2/Nrk |
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要素 | Tyrosine-protein kinase transmembrane receptor Ror2 |
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キーワード | SIGNALING PROTEIN / WNT signaling / receptor tyrosine kinases / acylation / growth factor signaling / co-receptor / pseudokinases / ligand / receptor / cancer |
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機能・相同性 | 機能・相同性情報
photoreceptor cell axon guidance / rhabdomere development / protein tyrosine kinase collagen receptor activity / multicellular organism development / positive regulation of kinase activity / muscle cell cellular homeostasis / plasma membrane => GO:0005886 / cell surface receptor protein tyrosine kinase signaling pathway / collagen binding / transmembrane receptor protein tyrosine kinase activity ...photoreceptor cell axon guidance / rhabdomere development / protein tyrosine kinase collagen receptor activity / multicellular organism development / positive regulation of kinase activity / muscle cell cellular homeostasis / plasma membrane => GO:0005886 / cell surface receptor protein tyrosine kinase signaling pathway / collagen binding / transmembrane receptor protein tyrosine kinase activity / receptor protein-tyrosine kinase / protein tyrosine kinase activity / receptor complex / protein phosphorylation / signal transduction / ATP binding / plasma membrane類似検索 - 分子機能 Tyrosine-protein kinase, receptor ROR / Frizzled domain / Frizzled cysteine-rich domain superfamily / Fz domain / Frizzled (fz) domain profile. / Kringle domain / Kringle / Kringle, conserved site / Kringle superfamily / Kringle domain signature. ...Tyrosine-protein kinase, receptor ROR / Frizzled domain / Frizzled cysteine-rich domain superfamily / Fz domain / Frizzled (fz) domain profile. / Kringle domain / Kringle / Kringle, conserved site / Kringle superfamily / Kringle domain signature. / Kringle domain profile. / Kringle domain / Kringle-like fold / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Tyrosine-protein kinase, active site / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily類似検索 - ドメイン・相同性 PALMITOLEIC ACID / Tyrosine-protein kinase transmembrane receptor Ror2類似検索 - 構成要素 |
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生物種 | ![](img/tx_arthropod.gif) Drosophila melanogaster (キイロショウジョウバエ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.75 Å |
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データ登録者 | Mendrola, J.M. / Shi, F. / Perry, K. / Stayrook, S.E. / Lemmon, M.A. |
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資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | R35-GM122485 | 米国 |
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引用 | ジャーナル: Cell Rep / 年: 2021 タイトル: ROR and RYK extracellular region structures suggest that receptor tyrosine kinases have distinct WNT-recognition modes. 著者: Shi, F. / Mendrola, J.M. / Sheetz, J.B. / Wu, N. / Sommer, A. / Speer, K.F. / Noordermeer, J.N. / Kan, Z.Y. / Perry, K. / Englander, S.W. / Stayrook, S.E. / Fradkin, L.G. / Lemmon, M.A. |
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履歴 | 登録 | 2021年4月6日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2021年10月13日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2021年11月24日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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改定 1.2 | 2023年10月18日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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