登録情報 | データベース: PDB / ID: 7d8s |
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タイトル | MITF bHLHLZ apo structure |
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要素 | Microphthalmia-associated transcription factor,Methionyl-tRNA synthetase beta subunit |
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キーワード | TRANSCRIPTION (転写 (生物学)) / TRANSCRIPTION FACTOR (転写因子) |
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機能・相同性 | 機能・相同性情報
melanocyte apoptotic process / positive regulation of DNA-templated transcription initiation / regulation of RNA biosynthetic process / methionine-tRNA ligase activity / methionyl-tRNA aminoacylation / regulation of osteoclast differentiation / melanocyte differentiation / bone remodeling / camera-type eye development / E-box binding ...melanocyte apoptotic process / positive regulation of DNA-templated transcription initiation / regulation of RNA biosynthetic process / methionine-tRNA ligase activity / methionyl-tRNA aminoacylation / regulation of osteoclast differentiation / melanocyte differentiation / bone remodeling / camera-type eye development / E-box binding / SUMOylation of transcription factors / 細胞分化 / negative regulation of cell migration / osteoclast differentiation / Wntシグナル経路 / DNA-binding transcription repressor activity, RNA polymerase II-specific / regulation of cell population proliferation / protein-containing complex assembly / DNA-binding transcription activator activity, RNA polymerase II-specific / tRNA binding / protein dimerization activity / DNA-binding transcription factor activity, RNA polymerase II-specific / RNA polymerase II cis-regulatory region sequence-specific DNA binding / lysosomal membrane / chromatin binding / クロマチン / positive regulation of gene expression / regulation of DNA-templated transcription / regulation of transcription by RNA polymerase II / negative regulation of apoptotic process / positive regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / protein-containing complex / 核質 / ATP binding / 細胞核 / 細胞質類似検索 - 分子機能 MiT/TFE transcription factors, C-terminal / MiT/TFE transcription factors, N-terminal / Domain of unknown function (DUF3371) / MITF/TFEB/TFEC/TFE3 N-terminus / Methionyl-tRNA synthetase, beta subunit, C-terminal / tRNA-binding domain / Putative tRNA binding domain / tRNA-binding domain profile. / Helix-loop-helix DNA-binding domain / Helix-loop-helix DNA-binding domain superfamily ...MiT/TFE transcription factors, C-terminal / MiT/TFE transcription factors, N-terminal / Domain of unknown function (DUF3371) / MITF/TFEB/TFEC/TFE3 N-terminus / Methionyl-tRNA synthetase, beta subunit, C-terminal / tRNA-binding domain / Putative tRNA binding domain / tRNA-binding domain profile. / Helix-loop-helix DNA-binding domain / Helix-loop-helix DNA-binding domain superfamily / helix loop helix domain / Myc-type, basic helix-loop-helix (bHLH) domain / Myc-type, basic helix-loop-helix (bHLH) domain profile. / Nucleic acid-binding, OB-fold類似検索 - ドメイン・相同性 Methionyl-tRNA synthetase beta subunit / 小眼球症関連転写因子類似検索 - 構成要素 |
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生物種 | ![](img/tx_human.gif) Homo sapiens (ヒト)
![](img/tx_bacteria.gif) ![](img/tx_thermo.gif) Aquifex aeolicus VF5 (バクテリア) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.28 Å |
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データ登録者 | Guo, M. / Fang, P. / Wang, J. |
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資金援助 | 中国, 4件 組織 | 認可番号 | 国 |
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National Natural Science Foundation of China (NSFC) | 21778064 | 中国 | National Natural Science Foundation of China (NSFC) | 21778067 | 中国 | National Natural Science Foundation of China (NSFC) | 21977108 | 中国 | National Natural Science Foundation of China (NSFC) | 21977107 | 中国 |
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引用 | ジャーナル: Cell Res. / 年: 2023 タイトル: A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy. 著者: Liu, Z. / Chen, K. / Dai, J. / Xu, P. / Sun, W. / Liu, W. / Zhao, Z. / Bennett, S.P. / Li, P. / Ma, T. / Lin, Y. / Kawakami, A. / Yu, J. / Wang, F. / Wang, C. / Li, M. / Chase, P. / Hodder, P. ...著者: Liu, Z. / Chen, K. / Dai, J. / Xu, P. / Sun, W. / Liu, W. / Zhao, Z. / Bennett, S.P. / Li, P. / Ma, T. / Lin, Y. / Kawakami, A. / Yu, J. / Wang, F. / Wang, C. / Li, M. / Chase, P. / Hodder, P. / Spicer, T.P. / Scampavia, L. / Cao, C. / Pan, L. / Dong, J. / Chen, Y. / Yu, B. / Guo, M. / Fang, P. / Fisher, D.E. / Wang, J. |
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履歴 | 登録 | 2020年10月9日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2021年10月13日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年9月27日 | Group: Data collection / Database references カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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改定 1.2 | 2023年11月29日 | Group: Refinement description / カテゴリ: pdbx_initial_refinement_model |
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