Entry | Database: PDB / ID: 7cp1 |
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Title | Crystal structure of isocitrate lyase in complex with succinate and itaconate |
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Components | Isocitrate lyase |
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Keywords | LYASE / Glyoxylate cycle / Isocitrate lyase / Succinate / Itaconate / Mycobacterium tuberculosis |
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Function / homology | Function and homology information
methylisocitrate lyase activity / isocitrate lyase / glyoxysome / isocitrate lyase activity / isocitrate metabolic process / response to host immune response / zymogen binding / glyoxylate cycle / tricarboxylic acid cycle / cellular response to hypoxia ...methylisocitrate lyase activity / isocitrate lyase / glyoxysome / isocitrate lyase activity / isocitrate metabolic process / response to host immune response / zymogen binding / glyoxylate cycle / tricarboxylic acid cycle / cellular response to hypoxia / extracellular region / metal ion binding / plasma membrane / cytosolSimilarity search - Function Isocitrate lyase / Isocitrate lyase family / Isocitrate lyase/phosphorylmutase, conserved site / Isocitrate lyase signature. / Pyruvate kinase-like domain superfamily / Pyruvate/Phosphoenolpyruvate kinase-like domain superfamilySimilarity search - Domain/homology |
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Biological species | Mycobacterium tuberculosis H37Rv (bacteria) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.58 Å |
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Authors | Kwon, S. / Park, H.H. |
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Funding support | Korea, Republic Of, 2items Organization | Grant number | Country |
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National Research Foundation (NRF, Korea) | 2017M3A9D8062960 | | National Research Foundation (NRF, Korea) | 2018R1A4A1023822 | Korea, Republic Of |
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Citation | Journal: Plos One / Year: 2021 Title: Heterogeneous multimeric structure of isocitrate lyase in complex with succinate and itaconate provides novel insights into its inhibitory mechanism. Authors: Kwon, S. / Chun, H.L. / Ha, H.J. / Lee, S.Y. / Park, H.H. |
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History | Deposition | Aug 5, 2020 | Deposition site: PDBJ / Processing site: PDBJ |
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Revision 1.0 | May 19, 2021 | Provider: repository / Type: Initial release |
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Revision 1.1 | Nov 29, 2023 | Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ncs_dom_lim Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id |
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