Entry | Database: PDB / ID: 6xpp |
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Title | Crystal structure of itaconate modified Mycobaterium tuberculosis isocitrate lyase |
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Components | Isocitrate lyase |
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Keywords | LYASE / covalent modification |
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Function / homology | Function and homology information
methylisocitrate lyase activity / isocitrate lyase / glyoxysome / isocitrate lyase activity / isocitrate metabolic process / response to host immune response / zymogen binding / glyoxylate cycle / tricarboxylic acid cycle / cellular response to hypoxia ...methylisocitrate lyase activity / isocitrate lyase / glyoxysome / isocitrate lyase activity / isocitrate metabolic process / response to host immune response / zymogen binding / glyoxylate cycle / tricarboxylic acid cycle / cellular response to hypoxia / extracellular region / metal ion binding / plasma membrane / cytosolSimilarity search - Function Isocitrate lyase / Isocitrate lyase family / Isocitrate lyase/phosphorylmutase, conserved site / Isocitrate lyase signature. / Pyruvate kinase-like domain superfamily / Pyruvate/Phosphoenolpyruvate kinase-like domain superfamilySimilarity search - Domain/homology |
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Biological species | ![](img/tx_bacteria.gif) Mycobacterium tuberculosis (bacteria) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.55 Å |
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Authors | Kwai, B.X.C. / Bashiri, G. / Leung, I.K.H. |
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Funding support | New Zealand, 2items Organization | Grant number | Country |
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Other private | | New Zealand | Health Research Council (HRC) | | New Zealand |
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Citation | Journal: Rsc Med Chem / Year: 2021 Title: Itaconate is a covalent inhibitor of the Mycobacterium tuberculosis isocitrate lyase. Authors: Kwai, B.X.C. / Collins, A.J. / Middleditch, M.J. / Sperry, J. / Bashiri, G. / Leung, I.K.H. |
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History | Deposition | Jul 8, 2020 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Oct 21, 2020 | Provider: repository / Type: Initial release |
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Revision 1.1 | Jun 9, 2021 | Group: Database references / Category: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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Revision 1.2 | Oct 18, 2023 | Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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