登録情報 | データベース: PDB / ID: 7c53 |
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タイトル | Crystal Structure of SARS-CoV-2 HR1 motif in complex with pan-CoVs inhibitor EK1 |
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要素 | Spike protein S2',pan-CoVs inhibitor EK1 |
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キーワード | VIRAL PROTEIN / SARS-CoV-2 HR1 / pan-CoVs inhibitor / EK1 peptide / VIRUS |
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機能・相同性 | 機能・相同性情報
Maturation of spike protein / viral translation / Translation of Structural Proteins / Virion Assembly and Release / host cell surface / host extracellular space / suppression by virus of host tetherin activity / Induction of Cell-Cell Fusion / structural constituent of virion / entry receptor-mediated virion attachment to host cell ...Maturation of spike protein / viral translation / Translation of Structural Proteins / Virion Assembly and Release / host cell surface / host extracellular space / suppression by virus of host tetherin activity / Induction of Cell-Cell Fusion / structural constituent of virion / entry receptor-mediated virion attachment to host cell / host cell endoplasmic reticulum-Golgi intermediate compartment membrane / receptor-mediated endocytosis of virus by host cell / Attachment and Entry / membrane fusion / symbiont-mediated suppression of host innate immune response / positive regulation of viral entry into host cell / receptor-mediated virion attachment to host cell / receptor ligand activity / host cell surface receptor binding / fusion of virus membrane with host plasma membrane / fusion of virus membrane with host endosome membrane / viral envelope / virion attachment to host cell / SARS-CoV-2 activates/modulates innate and adaptive immune responses / host cell plasma membrane / virion membrane / identical protein binding / membrane / plasma membrane類似検索 - 分子機能 Spike (S) protein S1 subunit, receptor-binding domain, SARS-CoV-2 / Spike (S) protein S1 subunit, N-terminal domain, SARS-CoV-like / Betacoronavirus spike (S) glycoprotein S1 subunit N-terminal (NTD) domain profile. / Spike glycoprotein, N-terminal domain superfamily / Betacoronavirus spike (S) glycoprotein S1 subunit C-terminal (CTD) domain profile. / Spike glycoprotein, betacoronavirus / Spike (S) protein S1 subunit, receptor-binding domain, betacoronavirus / Spike S1 subunit, receptor binding domain superfamily, betacoronavirus / Betacoronavirus spike glycoprotein S1, receptor binding / Spike glycoprotein S1, N-terminal domain, betacoronavirus-like ...Spike (S) protein S1 subunit, receptor-binding domain, SARS-CoV-2 / Spike (S) protein S1 subunit, N-terminal domain, SARS-CoV-like / Betacoronavirus spike (S) glycoprotein S1 subunit N-terminal (NTD) domain profile. / Spike glycoprotein, N-terminal domain superfamily / Betacoronavirus spike (S) glycoprotein S1 subunit C-terminal (CTD) domain profile. / Spike glycoprotein, betacoronavirus / Spike (S) protein S1 subunit, receptor-binding domain, betacoronavirus / Spike S1 subunit, receptor binding domain superfamily, betacoronavirus / Betacoronavirus spike glycoprotein S1, receptor binding / Spike glycoprotein S1, N-terminal domain, betacoronavirus-like / Betacoronavirus-like spike glycoprotein S1, N-terminal / Spike glycoprotein S2, coronavirus, heptad repeat 1 / Spike glycoprotein S2, coronavirus, heptad repeat 2 / Coronavirus spike (S) glycoprotein S2 subunit heptad repeat 2 (HR2) region profile. / Coronavirus spike (S) glycoprotein S2 subunit heptad repeat 1 (HR1) region profile. / Spike glycoprotein S2 superfamily, coronavirus / Spike glycoprotein S2, coronavirus / Coronavirus spike glycoprotein S2 / Coronavirus spike glycoprotein S1, C-terminal / Coronavirus spike glycoprotein S1, C-terminal類似検索 - ドメイン・相同性 |
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生物種 | ![](img/tx_virus.gif) Severe acute respiratory syndrome coronavirus 2 (ウイルス) synthetic construct (人工物) |
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手法 | X線回折 / 分子置換 / 解像度: 2.278 Å |
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データ登録者 | Zhu, Y. / Yang, X. / Sun, F. |
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引用 | ジャーナル: Signal Transduct Target Ther / 年: 2021 タイトル: Structural and functional basis for pan-CoV fusion inhibitors against SARS-CoV-2 and its variants with preclinical evaluation. 著者: Xia, S. / Lan, Q. / Zhu, Y. / Wang, C. / Xu, W. / Li, Y. / Wang, L. / Jiao, F. / Zhou, J. / Hua, C. / Wang, Q. / Cai, X. / Wu, Y. / Gao, J. / Liu, H. / Sun, G. / Munch, J. / Kirchhoff, F. / ...著者: Xia, S. / Lan, Q. / Zhu, Y. / Wang, C. / Xu, W. / Li, Y. / Wang, L. / Jiao, F. / Zhou, J. / Hua, C. / Wang, Q. / Cai, X. / Wu, Y. / Gao, J. / Liu, H. / Sun, G. / Munch, J. / Kirchhoff, F. / Yuan, Z. / Xie, Y. / Sun, F. / Jiang, S. / Lu, L. |
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履歴 | 登録 | 2020年5月19日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2021年5月19日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2021年12月1日 | Group: Database references / カテゴリ: citation / citation_author / database_2 Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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改定 1.2 | 2023年11月29日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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