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- PDB-1vca: CRYSTAL STRUCTURE OF AN INTEGRIN-BINDING FRAGMENT OF VASCULAR CEL... -
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Basic information
Entry | Database: PDB / ID: 1vca | ||||||
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Title | CRYSTAL STRUCTURE OF AN INTEGRIN-BINDING FRAGMENT OF VASCULAR CELL ADHESION MOLECULE-1 AT 1.8 ANGSTROMS RESOLUTION | ||||||
![]() | HUMAN VASCULAR CELL ADHESION MOLECULE-1 | ||||||
![]() | CELL ADHESION PROTEIN / IMMUNOGLOBULIN SUPERFAMILY / INTEGRIN-BINDING | ||||||
Function / homology | ![]() cardiac neuron differentiation / alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex / cell adhesion mediator activity / cell-cell adhesion in response to extracellular stimulus / chronic inflammatory response / membrane to membrane docking / leukocyte tethering or rolling / innervation / primary methylamine oxidase activity / amine metabolic process ...cardiac neuron differentiation / alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex / cell adhesion mediator activity / cell-cell adhesion in response to extracellular stimulus / chronic inflammatory response / membrane to membrane docking / leukocyte tethering or rolling / innervation / primary methylamine oxidase activity / amine metabolic process / podosome / heterotypic cell-cell adhesion / heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules / leukocyte cell-cell adhesion / response to ionizing radiation / response to zinc ion / microvillus / : / cellular response to vascular endothelial growth factor stimulus / Integrin cell surface interactions / positive regulation of T cell proliferation / cell adhesion molecule binding / B cell differentiation / response to nutrient / cell-matrix adhesion / cell chemotaxis / filopodium / response to nicotine / sarcolemma / cellular response to amyloid-beta / Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell / Interferon gamma signaling / integrin binding / apical part of cell / cellular response to tumor necrosis factor / Interleukin-4 and Interleukin-13 signaling / response to ethanol / response to lipopolysaccharide / early endosome / cell adhesion / response to hypoxia / inflammatory response / external side of plasma membrane / Golgi apparatus / cell surface / endoplasmic reticulum / extracellular space / extracellular exosome / plasma membrane Similarity search - Function | ||||||
Biological species | ![]() | ||||||
Method | ![]() ![]() | ||||||
![]() | Jones, E.Y. / Harlos, K. / Bottomley, M.J. / Robinson, R.C. / Driscoll, P.C. / Edwards, R.M. / Clements, J.M. / Dudgeon, T.J. / Stuart, D.I. | ||||||
![]() | ![]() Title: Crystal structure of an integrin-binding fragment of vascular cell adhesion molecule-1 at 1.8 A resolution. Authors: Jones, E.Y. / Harlos, K. / Bottomley, M.J. / Robinson, R.C. / Driscoll, P.C. / Edwards, R.M. / Clements, J.M. / Dudgeon, T.J. / Stuart, D.I. #1: ![]() Title: Crystallization and Preliminary X-Ray Diffraction Characterisation of Both a Native and Selenomethionyl Vla-4 Binding Fragment of Vcam-1 Authors: Bottomley, M.J. / Robinson, R.C. / Driscoll, P.C. / Harlos, K. / Stuart, D.I. / Aplin, R.T. / Clements, J.M. / Jones, E.Y. / Dudgeon, T.J. #2: ![]() Title: Expression and Characterisation of a Very-Late Antigen-4 (Alpha4Beta1) Integrin Binding Fragment of Vascular Cell-Adhesion Molecule-1 Authors: Dudgeon, T.J. / Bottomley, M.J. / Driscoll, P.C. / Humphries, M.J. / Mould, A.P. / Wingfield, G.I. / Clements, J.M. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 89.8 KB | Display | ![]() |
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PDB format | ![]() | 73 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Summary document | ![]() | 374.1 KB | Display | ![]() |
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Full document | ![]() | 378.8 KB | Display | |
Data in XML | ![]() | 9.2 KB | Display | |
Data in CIF | ![]() | 15.2 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Similar structure data |
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Links
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Assembly
Deposited unit | ![]()
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1 | ![]()
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2 | ![]()
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Unit cell |
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Atom site foot note | 1: CIS PROLINE - PRO A 7 / 2: CIS PROLINE - PRO A 60 / 3: CIS PROLINE - PRO A 120 / 4: CIS PROLINE - PRO B 7 / 5: CIS PROLINE - PRO B 60 / 6: CIS PROLINE - PRO B 120 |
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Components
#1: Protein | Mass: 22535.574 Da / Num. of mol.: 2 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() #2: Water | ChemComp-HOH / | |
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-Experimental details
-Experiment
Experiment | Method: ![]() |
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Sample preparation
Crystal | Density Matthews: 2.2 Å3/Da / Density % sol: 44.07 % | ||||||||||||||||||||||||||||||
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Crystal grow | *PLUS Method: vapor diffusion, sitting drop / Details: Bottomley, M.J., (1994) J.Mol.Biol., 244, 464. | ||||||||||||||||||||||||||||||
Components of the solutions | *PLUS
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-Data collection
Diffraction source | Source: ![]() ![]() ![]() |
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Detector | Type: FUJI / Detector: IMAGE PLATE / Date: 1994 |
Radiation | Monochromatic (M) / Laue (L): M / Scattering type: x-ray |
Radiation wavelength | Wavelength: 0.97 Å / Relative weight: 1 |
Reflection | Num. obs: 32077 / % possible obs: 85 % / Observed criterion σ(I): 0 / Redundancy: 4.5 % / Rmerge(I) obs: 0.067 |
Reflection | *PLUS Highest resolution: 1.8 Å / Rmerge(I) obs: 0.087 |
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Processing
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Refinement | Resolution: 1.8→15 Å / σ(F): 0 /
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Refinement step | Cycle: LAST / Resolution: 1.8→15 Å
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Refine LS restraints |
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