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- PDB-7c53: Crystal Structure of SARS-CoV-2 HR1 motif in complex with pan-CoV... -
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Open data
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Basic information
Entry | Database: PDB / ID: 7c53 | ||||||
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Title | Crystal Structure of SARS-CoV-2 HR1 motif in complex with pan-CoVs inhibitor EK1 | ||||||
![]() | Spike protein S2',pan-CoVs inhibitor EK1 | ||||||
![]() | VIRAL PROTEIN / SARS-CoV-2 HR1 / pan-CoVs inhibitor / EK1 peptide / VIRUS | ||||||
Function / homology | ![]() Maturation of spike protein / viral translation / Translation of Structural Proteins / Virion Assembly and Release / host cell surface / host extracellular space / suppression by virus of host tetherin activity / Induction of Cell-Cell Fusion / structural constituent of virion / entry receptor-mediated virion attachment to host cell ...Maturation of spike protein / viral translation / Translation of Structural Proteins / Virion Assembly and Release / host cell surface / host extracellular space / suppression by virus of host tetherin activity / Induction of Cell-Cell Fusion / structural constituent of virion / entry receptor-mediated virion attachment to host cell / host cell endoplasmic reticulum-Golgi intermediate compartment membrane / receptor-mediated endocytosis of virus by host cell / Attachment and Entry / membrane fusion / symbiont-mediated suppression of host innate immune response / positive regulation of viral entry into host cell / receptor-mediated virion attachment to host cell / receptor ligand activity / host cell surface receptor binding / fusion of virus membrane with host plasma membrane / fusion of virus membrane with host endosome membrane / viral envelope / virion attachment to host cell / SARS-CoV-2 activates/modulates innate and adaptive immune responses / host cell plasma membrane / virion membrane / identical protein binding / membrane / plasma membrane Similarity search - Function | ||||||
Biological species | ![]() ![]() synthetic construct (others) | ||||||
Method | ![]() ![]() ![]() | ||||||
![]() | Zhu, Y. / Yang, X. / Sun, F. | ||||||
![]() | ![]() Title: Structural and functional basis for pan-CoV fusion inhibitors against SARS-CoV-2 and its variants with preclinical evaluation. Authors: Xia, S. / Lan, Q. / Zhu, Y. / Wang, C. / Xu, W. / Li, Y. / Wang, L. / Jiao, F. / Zhou, J. / Hua, C. / Wang, Q. / Cai, X. / Wu, Y. / Gao, J. / Liu, H. / Sun, G. / Munch, J. / Kirchhoff, F. / ...Authors: Xia, S. / Lan, Q. / Zhu, Y. / Wang, C. / Xu, W. / Li, Y. / Wang, L. / Jiao, F. / Zhou, J. / Hua, C. / Wang, Q. / Cai, X. / Wu, Y. / Gao, J. / Liu, H. / Sun, G. / Munch, J. / Kirchhoff, F. / Yuan, Z. / Xie, Y. / Sun, F. / Jiang, S. / Lu, L. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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PDBx/mmCIF format | ![]() | 230.5 KB | Display | ![]() |
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PDB format | ![]() | 186.7 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Arichive directory | ![]() ![]() | HTTPS FTP |
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-Related structure data
Related structure data | ![]() 5zvmS S: Starting model for refinement |
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Similar structure data |
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Assembly
Deposited unit | ![]()
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Unit cell |
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Components on special symmetry positions |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments:
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