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TitleStructural and functional basis for pan-CoV fusion inhibitors against SARS-CoV-2 and its variants with preclinical evaluation.
Journal, issue, pagesSignal Transduct Target Ther, Vol. 6, Page 288-288, Year 2021
Publish dateMay 19, 2020 (structure data deposition date)
AuthorsXia, S. / Lan, Q. / Zhu, Y. / Wang, C. / Xu, W. / Li, Y. / Wang, L. / Jiao, F. / Zhou, J. / Hua, C. ...Xia, S. / Lan, Q. / Zhu, Y. / Wang, C. / Xu, W. / Li, Y. / Wang, L. / Jiao, F. / Zhou, J. / Hua, C. / Wang, Q. / Cai, X. / Wu, Y. / Gao, J. / Liu, H. / Sun, G. / Munch, J. / Kirchhoff, F. / Yuan, Z. / Xie, Y. / Sun, F. / Jiang, S. / Lu, L.
External linksSignal Transduct Target Ther / PubMed:34326308
MethodsX-ray diffraction
Resolution2.278 Å
Structure data

PDB-7c53:
Crystal Structure of SARS-CoV-2 HR1 motif in complex with pan-CoVs inhibitor EK1
Method: X-RAY DIFFRACTION / Resolution: 2.278 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-HOH:
WATER

Source
  • severe acute respiratory syndrome coronavirus 2
  • synthetic construct (others)
KeywordsVIRAL PROTEIN / SARS-CoV-2 HR1 / pan-CoVs inhibitor / EK1 peptide / VIRUS

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