登録情報 | データベース: PDB / ID: 6zg9 |
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タイトル | Structure of M1-StaR-T4L in complex with GSK1034702 at 2.5A |
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要素 | Muscarinic acetylcholine receptor M1,Endolysin,Muscarinic acetylcholine receptor M1 |
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キーワード | MEMBRANE PROTEIN / GPCR / 7TM |
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機能・相同性 | 機能・相同性情報
saliva secretion / regulation of glial cell proliferation / positive regulation of monoatomic ion transport / Muscarinic acetylcholine receptors / phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway / G protein-coupled acetylcholine receptor activity / neuromuscular synaptic transmission / cholinergic synapse / adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway / positive regulation of intracellular protein transport ...saliva secretion / regulation of glial cell proliferation / positive regulation of monoatomic ion transport / Muscarinic acetylcholine receptors / phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway / G protein-coupled acetylcholine receptor activity / neuromuscular synaptic transmission / cholinergic synapse / adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway / positive regulation of intracellular protein transport / phosphatidylinositol phospholipase C activity / G protein-coupled serotonin receptor activity / : / regulation of locomotion / postsynaptic modulation of chemical synaptic transmission / G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger / regulation of postsynaptic membrane potential / axon terminus / viral release from host cell by cytolysis / peptidoglycan catabolic process / postsynaptic density membrane / Schaffer collateral - CA1 synapse / G protein-coupled acetylcholine receptor signaling pathway / cognition / cell wall macromolecule catabolic process / lysozyme / lysozyme activity / nervous system development / presynaptic membrane / G alpha (q) signalling events / chemical synaptic transmission / host cell cytoplasm / defense response to bacterium / G protein-coupled receptor signaling pathway / glutamatergic synapse / synapse / dendrite / signal transduction / membrane / plasma membrane類似検索 - 分子機能 Muscarinic acetylcholine receptor M1 / Muscarinic acetylcholine receptor family / Endolysin T4 type / : / T4-type lysozyme / Glycoside hydrolase, family 24 / Lysozyme domain superfamily / Phage lysozyme / G-protein coupled receptors family 1 signature. / G protein-coupled receptor, rhodopsin-like ...Muscarinic acetylcholine receptor M1 / Muscarinic acetylcholine receptor family / Endolysin T4 type / : / T4-type lysozyme / Glycoside hydrolase, family 24 / Lysozyme domain superfamily / Phage lysozyme / G-protein coupled receptors family 1 signature. / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family) / Lysozyme-like domain superfamily類似検索 - ドメイン・相同性 OLEIC ACID / PHOSPHATE ION / Chem-QK2 / Endolysin / Muscarinic acetylcholine receptor M1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト)
Enterobacteria phage T4 (ファージ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.5 Å |
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データ登録者 | Rucktooa, P. / Cooke, R.M. |
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引用 | ジャーナル: Cell / 年: 2021 タイトル: From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease. 著者: Brown, A.J.H. / Bradley, S.J. / Marshall, F.H. / Brown, G.A. / Bennett, K.A. / Brown, J. / Cansfield, J.E. / Cross, D.M. / de Graaf, C. / Hudson, B.D. / Dwomoh, L. / Dias, J.M. / Errey, J.C. ...著者: Brown, A.J.H. / Bradley, S.J. / Marshall, F.H. / Brown, G.A. / Bennett, K.A. / Brown, J. / Cansfield, J.E. / Cross, D.M. / de Graaf, C. / Hudson, B.D. / Dwomoh, L. / Dias, J.M. / Errey, J.C. / Hurrell, E. / Liptrot, J. / Mattedi, G. / Molloy, C. / Nathan, P.J. / Okrasa, K. / Osborne, G. / Patel, J.C. / Pickworth, M. / Robertson, N. / Shahabi, S. / Bundgaard, C. / Phillips, K. / Broad, L.M. / Goonawardena, A.V. / Morairty, S.R. / Browning, M. / Perini, F. / Dawson, G.R. / Deakin, J.F.W. / Smith, R.T. / Sexton, P.M. / Warneck, J. / Vinson, M. / Tasker, T. / Tehan, B.G. / Teobald, B. / Christopoulos, A. / Langmead, C.J. / Jazayeri, A. / Cooke, R.M. / Rucktooa, P. / Congreve, M.S. / Weir, M. / Tobin, A.B. |
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履歴 | 登録 | 2020年6月18日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2021年10月6日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2021年12月1日 | Group: Data collection / Database references / カテゴリ: citation / citation_author / diffrn_source Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.title / _citation.year / _diffrn_source.pdbx_synchrotron_site |
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改定 1.2 | 2021年12月8日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.pdbx_database_id_PubMed / _citation.title |
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改定 1.3 | 2024年1月24日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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