登録情報 | データベース: PDB / ID: 6zeh |
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タイトル | Structure of PP1-spectrin alpha II chimera [PP1(7-304) + linker (G/S)x9 + spectrin alpha II (1025-1039)] bound to Phactr1 (516-580) |
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要素 | - Phosphatase and actin regulator
- Serine/threonine-protein phosphatase PP1-alpha catalytic subunit,Spectrin alpha chain, non-erythrocytic 1
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キーワード | HYDROLASE / PP1 / Phosphatase / Phactr / RPEL |
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機能・相同性 | 機能・相同性情報
spectrin / regulation of glycogen catabolic process / PTW/PP1 phosphatase complex / glycogen granule / dendrite arborization / regulation of glycogen biosynthetic process / regulation of neuron migration / protein phosphatase 1 binding / cadherin binding involved in cell-cell adhesion / actin filament capping ...spectrin / regulation of glycogen catabolic process / PTW/PP1 phosphatase complex / glycogen granule / dendrite arborization / regulation of glycogen biosynthetic process / regulation of neuron migration / protein phosphatase 1 binding / cadherin binding involved in cell-cell adhesion / actin filament capping / positive regulation of extrinsic apoptotic signaling pathway in absence of ligand / actomyosin structure organization / regulation of canonical Wnt signaling pathway / Sensory processing of sound by outer hair cells of the cochlea / Interaction between L1 and Ankyrins / Sensory processing of sound by inner hair cells of the cochlea / Nephrin family interactions / regulation of translational initiation / protein phosphatase inhibitor activity / RHOV GTPase cycle / myosin phosphatase activity / cortical actin cytoskeleton / branching morphogenesis of an epithelial tube / protein serine/threonine phosphatase activity / glycogen metabolic process / protein-serine/threonine phosphatase / stress fiber assembly / Triglyceride catabolism / Maturation of hRSV A proteins / entrainment of circadian clock by photoperiod / phosphatase activity / phosphoprotein phosphatase activity / RHOU GTPase cycle / DARPP-32 events / Caspase-mediated cleavage of cytoskeletal proteins / ribonucleoprotein complex binding / COPI-mediated anterograde transport / dephosphorylation / NCAM signaling for neurite out-growth / protein dephosphorylation / Downregulation of TGF-beta receptor signaling / cell projection / cell motility / adherens junction / response to lead ion / lung development / circadian regulation of gene expression / regulation of circadian rhythm / structural constituent of cytoskeleton / cerebral cortex development / specific granule lumen / microtubule cytoskeleton / extracellular vesicle / actin filament binding / Circadian Clock / presynapse / tertiary granule lumen / cell junction / actin binding / actin cytoskeleton organization / RAF/MAP kinase cascade / perikaryon / dendritic spine / calmodulin binding / cadherin binding / cell cycle / cell division / intracellular membrane-bounded organelle / glutamatergic synapse / synapse / calcium ion binding / Neutrophil degranulation / nucleolus / extracellular exosome / extracellular region / nucleoplasm / membrane / nucleus / metal ion binding / plasma membrane / cytoplasm / cytosol類似検索 - 分子機能 RPEL repeat / RPEL repeat / RPEL repeat profile. / Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2 / Alpha Spectrin, SH3 domain / Serine-threonine protein phosphatase, N-terminal / Serine-threonine protein phosphatase N-terminal domain / EF-hand, Ca insensitive / Ca2+ insensitive EF hand / Ca2+ insensitive EF hand ...RPEL repeat / RPEL repeat / RPEL repeat profile. / Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2 / Alpha Spectrin, SH3 domain / Serine-threonine protein phosphatase, N-terminal / Serine-threonine protein phosphatase N-terminal domain / EF-hand, Ca insensitive / Ca2+ insensitive EF hand / Ca2+ insensitive EF hand / Serine/threonine specific protein phosphatases signature. / Protein phosphatase 2A homologues, catalytic domain. / Spectrin repeat / Spectrin repeat / Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase / Spectrin/alpha-actinin / Spectrin repeats / Calcineurin-like phosphoesterase domain, ApaH type / Calcineurin-like phosphoesterase / Metallo-dependent phosphatase-like / SH3 domain / EF-hand domain pair / EF-hand, calcium binding motif / Src homology 3 domains / EF-Hand 1, calcium-binding site / EF-hand calcium-binding domain. / EF-hand calcium-binding domain profile. / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain / EF-hand domain / EF-hand domain pair類似検索 - ドメイン・相同性 : / PHOSPHATE ION / Serine/threonine-protein phosphatase PP1-alpha catalytic subunit / Spectrin alpha chain, non-erythrocytic 1 / Phosphatase and actin regulator / Phosphatase and actin regulator 1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.3 Å |
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データ登録者 | Mouilleron, S. / Treisman, R. / Fedoryshchak, R. / Lee, R. / Butler, A.M. / Prechova, M. |
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引用 | ジャーナル: Elife / 年: 2020 タイトル: Molecular basis for substrate specificity of the Phactr1/PP1 phosphatase holoenzyme. 著者: Fedoryshchak, R.O. / Prechova, M. / Butler, A. / Lee, R. / O'Reilly, N. / Flynn, H.R. / Snijders, A.P. / Eder, N. / Ultanir, S. / Mouilleron, S. / Treisman, R. |
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履歴 | 登録 | 2020年6月16日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2020年9月30日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2020年10月7日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.journal_volume / _citation.pdbx_database_id_DOI ..._citation.journal_volume / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title |
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改定 1.2 | 2024年1月24日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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