登録情報 | データベース: PDB / ID: 6w9m |
---|
タイトル | Structure of the Ancestral Glucocorticoid Receptor 2 ligand binding domain in complex with vamorolone and SHP coregulator fragment |
---|
要素 | - Glucocorticoid Receptor
- Nuclear receptor subfamily 0 group B member 2
|
---|
キーワード | HORMONE / Glucocorticoid Receptor / anti-inflammation drug |
---|
機能・相同性 | 機能・相同性情報
transcription regulator inhibitor activity / peroxisome proliferator activated receptor binding / bile acid and bile salt transport / nuclear thyroid hormone receptor binding / animal organ regeneration / response to glucose / nuclear retinoid X receptor binding / Notch signaling pathway / cholesterol metabolic process / circadian regulation of gene expression ...transcription regulator inhibitor activity / peroxisome proliferator activated receptor binding / bile acid and bile salt transport / nuclear thyroid hormone receptor binding / animal organ regeneration / response to glucose / nuclear retinoid X receptor binding / Notch signaling pathway / cholesterol metabolic process / circadian regulation of gene expression / positive regulation of insulin secretion / negative regulation of DNA-binding transcription factor activity / response to organic cyclic compound / Nuclear Receptor transcription pathway / circadian rhythm / transcription corepressor activity / response to ethanol / protein domain specific binding / negative regulation of gene expression / intracellular membrane-bounded organelle / negative regulation of DNA-templated transcription / protein-containing complex binding / positive regulation of gene expression / chromatin / positive regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / protein homodimerization activity / nucleoplasm / nucleus / cytoplasm類似検索 - 分子機能 Nuclear receptor subfamily 0 group B member 1/2 / Nuclear hormone receptor / Nuclear hormone receptor, ligand-binding domain / Nuclear hormone receptor-like domain superfamily / Nuclear receptor (NR) ligand-binding (LBD) domain profile. / Ligand binding domain of hormone receptors / Ligand-binding domain of nuclear hormone receptor類似検索 - ドメイン・相同性 vamorolone / : / Nuclear receptor subfamily 0 group B member 2類似検索 - 構成要素 |
---|
生物種 | synthetic construct (人工物) Homo sapiens (ヒト) |
---|
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.59 Å |
---|
データ登録者 | Liu, X. / Ortlund, E.A. |
---|
資金援助 | 米国, 2件 組織 | 認可番号 | 国 |
---|
American Heart Association | 17POST33660110 | 米国 | National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK) | R01DK095750 | 米国 |
|
---|
引用 | ジャーナル: Proc.Natl.Acad.Sci.USA / 年: 2020 タイトル: Disruption of a key ligand-H-bond network drives dissociative properties in vamorolone for Duchenne muscular dystrophy treatment. 著者: Liu, X. / Wang, Y. / Gutierrez, J.S. / Damsker, J.M. / Nagaraju, K. / Hoffman, E.P. / Ortlund, E.A. |
---|
履歴 | 登録 | 2020年3月23日 | 登録サイト: RCSB / 処理サイト: RCSB |
---|
改定 1.0 | 2020年11月4日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2023年10月18日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
---|
|
---|