Entry Database : PDB / ID : 5ufs Structure visualization Downloads & linksTitle X-Ray Crystal Structure of the Ancestral Glucocorticoid Receptor 2 ligand binding domain in complex with triamcinolone acetonide and SHP coregulator fragment ComponentsAncestral Glucocorticoid Receptor2 SHP NR Box 1 Peptide DetailsKeywords HORMONE RECEPTOR / Nuclear receptors / glucocorticoid receptor / ligand binding domainFunction / homology Function and homology informationFunction Domain/homology Component
bile acid and bile salt transport / transcription regulator inhibitor activity / peroxisome proliferator activated receptor binding / nuclear thyroid hormone receptor binding / animal organ regeneration / estrogen response element binding / response to glucose / nuclear retinoid X receptor binding / nuclear receptor-mediated steroid hormone signaling pathway / Notch signaling pathway ... bile acid and bile salt transport / transcription regulator inhibitor activity / peroxisome proliferator activated receptor binding / nuclear thyroid hormone receptor binding / animal organ regeneration / estrogen response element binding / response to glucose / nuclear retinoid X receptor binding / nuclear receptor-mediated steroid hormone signaling pathway / Notch signaling pathway / cholesterol metabolic process / circadian regulation of gene expression / positive regulation of insulin secretion / response to organic cyclic compound / negative regulation of DNA-binding transcription factor activity / Nuclear Receptor transcription pathway / circadian rhythm / transcription corepressor activity / nuclear receptor activity / response to ethanol / protein domain specific binding / negative regulation of gene expression / intracellular membrane-bounded organelle / negative regulation of DNA-templated transcription / protein-containing complex binding / positive regulation of gene expression / chromatin / positive regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / protein homodimerization activity / nucleoplasm / nucleus / cytoplasm Similarity search - Function Nuclear receptor subfamily 0 group B member 1/2 / Retinoid X Receptor / Retinoid X Receptor / Nuclear hormone receptor / Nuclear hormone receptor, ligand-binding domain / Nuclear hormone receptor-like domain superfamily / Ligand-binding domain of nuclear hormone receptor / Nuclear receptor (NR) ligand-binding (LBD) domain profile. / Ligand binding domain of hormone receptors / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species unidentified (others) Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.118 Å DetailsAuthors Weikum, E.R. / Ortlund, E.A. Funding support United States, 1items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) 1F31GM113397-01A1 United States
CitationJournal : Mol. Pharmacol. / Year : 2017Title : Structural Analysis of the Glucocorticoid Receptor Ligand-Binding Domain in Complex with Triamcinolone Acetonide and a Fragment of the Atypical Coregulator, Small Heterodimer Partner.Authors : Weikum, E.R. / Okafor, C.D. / D'Agostino, E.H. / Colucci, J.K. / Ortlund, E.A. History Deposition Jan 5, 2017 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Apr 26, 2017 Provider : repository / Type : Initial releaseRevision 1.1 Jun 7, 2017 Group : Database referencesRevision 1.2 Sep 27, 2017 Group : Author supporting evidence / Refinement description / Category : pdbx_audit_support / softwareItem : _pdbx_audit_support.funding_organization / _pdbx_audit_support.grant_numberRevision 1.3 Jan 1, 2020 Group : Author supporting evidence / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organizationRevision 1.4 Oct 4, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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