登録情報 | データベース: PDB / ID: 6v2s |
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タイトル | Crystal Structure of chromodomain of MPP8 in complex with inhibitor UNC3866 |
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要素 | - M-phase phosphoprotein 8
- UNC3866
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キーワード | GENE REGULATION / structural genomics / Structural Genomics Consortium / SGC |
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機能・相同性 | 機能・相同性情報
positive regulation of DNA methylation-dependent heterochromatin formation / negative regulation of single stranded viral RNA replication via double stranded DNA intermediate / negative regulation of gene expression via chromosomal CpG island methylation / negative regulation of gene expression, epigenetic / heterochromatin / histone reader activity / methylated histone binding / nucleosome / chromatin binding / nucleolus ...positive regulation of DNA methylation-dependent heterochromatin formation / negative regulation of single stranded viral RNA replication via double stranded DNA intermediate / negative regulation of gene expression via chromosomal CpG island methylation / negative regulation of gene expression, epigenetic / heterochromatin / histone reader activity / methylated histone binding / nucleosome / chromatin binding / nucleolus / nucleoplasm / nucleus / plasma membrane / cytosol / cytoplasm類似検索 - 分子機能 Chromo domain, conserved site / Chromo domain signature. / Chromo domain / Chromo (CHRromatin Organisation MOdifier) domain / Chromo and chromo shadow domain profile. / OB fold (Dihydrolipoamide Acetyltransferase, E2P) - #40 / Chromo/chromo shadow domain / Chromatin organization modifier domain / Chromo-like domain superfamily / Ankyrin repeat ...Chromo domain, conserved site / Chromo domain signature. / Chromo domain / Chromo (CHRromatin Organisation MOdifier) domain / Chromo and chromo shadow domain profile. / OB fold (Dihydrolipoamide Acetyltransferase, E2P) - #40 / Chromo/chromo shadow domain / Chromatin organization modifier domain / Chromo-like domain superfamily / Ankyrin repeat / Ankyrin repeats (3 copies) / Ankyrin repeat profile. / Ankyrin repeat region circular profile. / ankyrin repeats / Ankyrin repeat / Ankyrin repeat-containing domain superfamily / OB fold (Dihydrolipoamide Acetyltransferase, E2P) / Beta Barrel / Mainly Beta類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) synthetic construct (人工物) |
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手法 | X線回折 / 分子置換 / 解像度: 1.6 Å |
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データ登録者 | Liu, Y. / Tempel, W. / Walker, J.R. / Bountra, C. / Arrowsmith, C.H. / Edwards, A.M. / Min, J. / Structural Genomics Consortium (SGC) |
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引用 | ジャーナル: Cell Chem Biol / 年: 2020 タイトル: Structural Basis for the Binding Selectivity of Human CDY Chromodomains. 著者: Dong, C. / Liu, Y. / Lyu, T.J. / Beldar, S. / Lamb, K.N. / Tempel, W. / Li, Y. / Li, Z. / James, L.I. / Qin, S. / Wang, Y. / Min, J. |
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履歴 | 登録 | 2019年11月25日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2019年12月25日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2020年6月17日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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改定 1.2 | 2020年7月29日 | Group: Database references / カテゴリ: citation Item: _citation.journal_volume / _citation.page_first / _citation.page_last |
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改定 1.3 | 2023年10月11日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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