登録情報 | データベース: PDB / ID: 6uap |
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タイトル | Crystal structure of tryptophan synthase from M. tuberculosis - open form with BRD6309 bound |
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要素 | (Tryptophan synthase ...) x 2 |
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キーワード | Lyase/Lyase Inhibitor / PLP / heterotetramer / amino acid biosynthesis / substrate channeling / allostery / Structural Genomics / Center for Structural Genomics of Infectious Diseases / CSGID / Lyase-Lyase Inhibitor complex |
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機能・相同性 | 機能・相同性情報
tryptophan synthase / tryptophan synthase activity / tryptophan biosynthetic process / plasma membrane / cytoplasm / cytosol類似検索 - 分子機能 Tryptophan synthase, alpha chain / Tryptophan synthase, alpha chain, active site / Tryptophan synthase alpha chain / Tryptophan synthase alpha chain signature. / Tryptophan synthase, beta chain, conserved site / Tryptophan synthase, beta chain / Tryptophan synthase beta chain/beta chain-like / Tryptophan synthase beta chain pyridoxal-phosphate attachment site. / Rossmann fold - #1100 / Pyridoxal-phosphate dependent enzyme ...Tryptophan synthase, alpha chain / Tryptophan synthase, alpha chain, active site / Tryptophan synthase alpha chain / Tryptophan synthase alpha chain signature. / Tryptophan synthase, beta chain, conserved site / Tryptophan synthase, beta chain / Tryptophan synthase beta chain/beta chain-like / Tryptophan synthase beta chain pyridoxal-phosphate attachment site. / Rossmann fold - #1100 / Pyridoxal-phosphate dependent enzyme / Tryptophan synthase beta subunit-like PLP-dependent enzyme / Pyridoxal-phosphate dependent enzyme / Ribulose-phosphate binding barrel / Aldolase class I / Aldolase-type TIM barrel / TIM Barrel / Alpha-Beta Barrel / Rossmann fold / 3-Layer(aba) Sandwich / Alpha Beta類似検索 - ドメイン・相同性 ACETATE ION / FORMIC ACID / Chem-H9V / MALONIC ACID / D-MALATE / Tryptophan synthase beta chain / Tryptophan synthase alpha chain類似検索 - 構成要素 |
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生物種 | ![](img/tx_bacteria.gif) Mycobacterium tuberculosis (結核菌) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.745 Å |
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データ登録者 | Chang, C. / Michalska, K. / Maltseva, N.I. / Jedrzejczak, R. / McCarren, P. / Nag, P.P. / Joachimiak, A. / Satchell, K. / Center for Structural Genomics of Infectious Diseases (CSGID) |
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資金援助 | カナダ, 1件 組織 | 認可番号 | 国 |
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Structure-guided Drug Discovery Coalition | | カナダ |
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引用 | ジャーナル: To be Published タイトル: Crystal structure of tryptophan synthase from M. tuberculosis - open form with BRD6309 bound 著者: Chang, C. / Michalska, K. / Maltseva, N.I. / Jedrzejczak, R. / McCarren, P. / Nag, P.P. / Joachimiak, A. / Satchell, K. |
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履歴 | 登録 | 2019年9月11日 | 登録サイト: RCSB / 処理サイト: RCSB |
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置き換え | 2019年10月30日 | ID: 6DU1 |
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改定 1.0 | 2019年10月30日 | Provider: repository / タイプ: Initial release |
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