Entry | Database: PDB / ID: 6uap |
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Title | Crystal structure of tryptophan synthase from M. tuberculosis - open form with BRD6309 bound |
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Components | (Tryptophan synthase ...) x 2 |
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Keywords | Lyase/Lyase Inhibitor / PLP / heterotetramer / amino acid biosynthesis / substrate channeling / allostery / Structural Genomics / Center for Structural Genomics of Infectious Diseases / CSGID / Lyase-Lyase Inhibitor complex |
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Function / homology | Function and homology information
tryptophan synthase / tryptophan synthase activity / tryptophan biosynthetic process / plasma membrane / cytoplasm / cytosolSimilarity search - Function Tryptophan synthase, alpha chain / Tryptophan synthase, alpha chain, active site / Tryptophan synthase alpha chain / Tryptophan synthase alpha chain signature. / Tryptophan synthase, beta chain, conserved site / Tryptophan synthase, beta chain / Tryptophan synthase beta chain/beta chain-like / Tryptophan synthase beta chain pyridoxal-phosphate attachment site. / Rossmann fold - #1100 / Pyridoxal-phosphate dependent enzyme ...Tryptophan synthase, alpha chain / Tryptophan synthase, alpha chain, active site / Tryptophan synthase alpha chain / Tryptophan synthase alpha chain signature. / Tryptophan synthase, beta chain, conserved site / Tryptophan synthase, beta chain / Tryptophan synthase beta chain/beta chain-like / Tryptophan synthase beta chain pyridoxal-phosphate attachment site. / Rossmann fold - #1100 / Pyridoxal-phosphate dependent enzyme / Tryptophan synthase beta subunit-like PLP-dependent enzyme / Pyridoxal-phosphate dependent enzyme / Ribulose-phosphate binding barrel / Aldolase class I / Aldolase-type TIM barrel / TIM Barrel / Alpha-Beta Barrel / Rossmann fold / 3-Layer(aba) Sandwich / Alpha BetaSimilarity search - Domain/homology ACETATE ION / FORMIC ACID / Chem-H9V / MALONIC ACID / D-MALATE / Tryptophan synthase beta chain / Tryptophan synthase alpha chainSimilarity search - Component |
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Biological species | ![](img/tx_bacteria.gif) Mycobacterium tuberculosis (bacteria) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.745 Å |
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Authors | Chang, C. / Michalska, K. / Maltseva, N.I. / Jedrzejczak, R. / McCarren, P. / Nag, P.P. / Joachimiak, A. / Satchell, K. / Center for Structural Genomics of Infectious Diseases (CSGID) |
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Funding support | Canada, 1items Organization | Grant number | Country |
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Structure-guided Drug Discovery Coalition | | Canada |
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Citation | Journal: To be Published Title: Crystal structure of tryptophan synthase from M. tuberculosis - open form with BRD6309 bound Authors: Chang, C. / Michalska, K. / Maltseva, N.I. / Jedrzejczak, R. / McCarren, P. / Nag, P.P. / Joachimiak, A. / Satchell, K. |
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History | Deposition | Sep 11, 2019 | Deposition site: RCSB / Processing site: RCSB |
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Supersession | Oct 30, 2019 | ID: 6DU1 |
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Revision 1.0 | Oct 30, 2019 | Provider: repository / Type: Initial release |
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