登録情報 データベース : PDB / ID : 6tm1 構造の表示 ダウンロードとリンクタイトル Crystal structure of the DHR2 domain of DOCK10 in complex with RAC3 要素(Dedicator of cytokinesis protein 10) x 2 Ras-related C3 botulinum toxin substrate 3 詳細キーワード SIGNALING PROTEIN / DOCK10 GEF RAC3 GTPase機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
cerebral cortex GABAergic interneuron development / marginal zone B cell differentiation / regulation of neuron maturation / regulation of neutrophil migration / postsynaptic actin cytoskeleton organization / NADPH oxidase complex / engulfment of apoptotic cell / respiratory burst / cortical cytoskeleton organization / dendritic spine morphogenesis ... cerebral cortex GABAergic interneuron development / marginal zone B cell differentiation / regulation of neuron maturation / regulation of neutrophil migration / postsynaptic actin cytoskeleton organization / NADPH oxidase complex / engulfment of apoptotic cell / respiratory burst / cortical cytoskeleton organization / dendritic spine morphogenesis / cell projection assembly / synaptic transmission, GABAergic / PCP/CE pathway / motor neuron axon guidance / positive regulation of cell adhesion mediated by integrin / establishment or maintenance of cell polarity / small GTPase-mediated signal transduction / Rac protein signal transduction / filamentous actin / B cell homeostasis / CDC42 GTPase cycle / neuromuscular process controlling balance / RAC2 GTPase cycle / RAC3 GTPase cycle / endomembrane system / positive regulation of substrate adhesion-dependent cell spreading / homeostasis of number of cells within a tissue / regulation of cell migration / RAC1 GTPase cycle / guanyl-nucleotide exchange factor activity / cell chemotaxis / small monomeric GTPase / G protein activity / positive regulation of GTPase activity / cell periphery / regulation of actin cytoskeleton organization / actin filament organization / Wnt signaling pathway / small GTPase binding / calcium-dependent protein binding / lamellipodium / Factors involved in megakaryocyte development and platelet production / regulation of cell shape / growth cone / cytoplasmic vesicle / actin cytoskeleton organization / dendritic spine / cytoskeleton / intracellular signal transduction / neuron projection / GTPase activity / neuronal cell body / glutamatergic synapse / endoplasmic reticulum membrane / GTP binding / protein kinase binding / perinuclear region of cytoplasm / extracellular exosome / nucleoplasm / membrane / nucleus / plasma membrane / cytoplasm / cytosol 類似検索 - 分子機能 DOCK DHR2 domain, lobe A / DOCK DHR2 domain, lobe C / Dedicator of cytokinesis D, C2 domain / Dedicator of cytokinesis C/D, N-terminal / Dedicator of cytokinesis C/D, N terminal / DOCKER, Lobe A / DOCKER, Lobe B / DOCKER, Lobe C / DHR-2, Lobe C / DHR-2, Lobe B ... DOCK DHR2 domain, lobe A / DOCK DHR2 domain, lobe C / Dedicator of cytokinesis D, C2 domain / Dedicator of cytokinesis C/D, N-terminal / Dedicator of cytokinesis C/D, N terminal / DOCKER, Lobe A / DOCKER, Lobe B / DOCKER, Lobe C / DHR-2, Lobe C / DHR-2, Lobe B / Dedicator of cytokinesis / C2 DOCK-type domain / DOCKER domain / Dedicator of cytokinesis, C-terminal, lobe A / Dedicator of cytokinesis, C-terminal, lobe C / DHR-2, Lobe A / C2 domain in Dock180 and Zizimin proteins / C2 DOCK-type domain profile. / DOCKER domain profile. / Small GTPase Rho / small GTPase Rho family profile. / PH domain / C2 domain superfamily / PH domain profile. / Pleckstrin homology domain. / Methane Monooxygenase Hydroxylase; Chain G, domain 1 / Pleckstrin homology domain / Rho (Ras homology) subfamily of Ras-like small GTPases / Ras subfamily of RAS small GTPases / Small GTPase / Ras family / Rab subfamily of small GTPases / Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat / Alpha Horseshoe / Small GTP-binding protein domain / PH-like domain superfamily / P-loop containing nucleotide triphosphate hydrolases / Up-down Bundle / Rossmann fold / P-loop containing nucleoside triphosphate hydrolase / 3-Layer(aba) Sandwich / Mainly Alpha / Alpha Beta 類似検索 - ドメイン・相同性 Ras-related C3 botulinum toxin substrate 3 / Dedicator of cytokinesis protein 10 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 3.71 Å 詳細データ登録者 Barford, D. / Fan, D. / Cronin, N. / Yang, J. 資金援助 英国, 1件 詳細 詳細を隠す組織 認可番号 国 Cancer Research UK C576/A14109 英国
引用ジャーナル : Biorxiv / 年 : 2022タイトル : Structural basis for CDC42 and RAC activation by the dual specificity GEF DOCK10著者 : Fan, D. / Yang, J. / Cronin, N. / Barford, D. 履歴 登録 2019年12月3日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2020年1月22日 Provider : repository / タイプ : Initial release改定 1.1 2022年6月29日 Group : Database references / カテゴリ : citation / citation_author / database_2Item : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.pdbx_database_id_DOI / _citation.title / _citation.year / _citation_author.identifier_ORCID / _database_2.pdbx_DOI / _database_2.pdbx_database_accession 改定 1.2 2024年1月24日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / citation / pdbx_initial_refinement_model Item : _citation.journal_id_ISSN
すべて表示 表示を減らす