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Structure paper

TitleStructural basis for CDC42 and RAC activation by the dual specificity GEF DOCK10
Journal, issue, pagesBiorxiv, Year 2022
Publish dateNov 29, 2019 (structure data deposition date)
AuthorsFan, D. / Yang, J. / Cronin, N. / Barford, D.
External linksBiorxiv / Search PubMed
MethodsX-ray diffraction
Resolution2.55 - 3.71 Å
Structure data

PDB-6tky:
Crystal structure of the DHR2 domain of DOCK10 in complex with CDC42
Method: X-RAY DIFFRACTION / Resolution: 2.55 Å

PDB-6tkz:
Crystal structure of the DHR2 domain of DOCK10 in complex with CDC42
Method: X-RAY DIFFRACTION / Resolution: 2.64 Å

PDB-6tm1:
Crystal structure of the DHR2 domain of DOCK10 in complex with RAC3
Method: X-RAY DIFFRACTION / Resolution: 3.71 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / DOCK10 GEF CDC42 GTPase / guanine nucleotide exchange factor / cytoskeleton / actin / cryoEM / DOCK10 GEF RAC3 GTPase

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