+Open data
-Basic information
Entry | Database: PDB / ID: 6s1i | ||||||
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Title | Crystal Structure of DYRK1A with small molecule inhibitor | ||||||
Components | Dual specificity tyrosine-phosphorylation-regulated kinase 1ADYRK1A | ||||||
Keywords | TRANSFERASE / Kinase / catalytic domain / phosphorylated | ||||||
Function / homology | Function and homology information histone H3T45 kinase activity / negative regulation of DNA methylation-dependent heterochromatin formation / positive regulation of protein deacetylation / peptidyl-serine autophosphorylation / dual-specificity kinase / [RNA-polymerase]-subunit kinase / negative regulation of microtubule polymerization / tau-protein kinase activity / negative regulation of mRNA splicing, via spliceosome / negative regulation of DNA damage response, signal transduction by p53 class mediator ...histone H3T45 kinase activity / negative regulation of DNA methylation-dependent heterochromatin formation / positive regulation of protein deacetylation / peptidyl-serine autophosphorylation / dual-specificity kinase / [RNA-polymerase]-subunit kinase / negative regulation of microtubule polymerization / tau-protein kinase activity / negative regulation of mRNA splicing, via spliceosome / negative regulation of DNA damage response, signal transduction by p53 class mediator / amyloid-beta formation / G0 and Early G1 / peptidyl-tyrosine autophosphorylation / cytoskeletal protein binding / protein serine/threonine/tyrosine kinase activity / tubulin binding / RNA polymerase II CTD heptapeptide repeat kinase activity / positive regulation of RNA splicing / tau protein binding / peptidyl-threonine phosphorylation / non-membrane spanning protein tyrosine kinase activity / circadian rhythm / peptidyl-tyrosine phosphorylation / protein self-association / nervous system development / actin binding / protein tyrosine kinase activity / peptidyl-serine phosphorylation / protein autophosphorylation / transcription coactivator activity / cytoskeleton / protein kinase activity / nuclear speck / ribonucleoprotein complex / axon / protein phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / dendrite / positive regulation of DNA-templated transcription / nucleoplasm / ATP binding / nucleus / identical protein binding / cytoplasm Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution: 2.38 Å | ||||||
Authors | Sorrell, F.J. / Henderson, S.H. / Redondo, C. / Burgess-Brown, N.A. / von Delft, F. / Arrowsmith, C.H. / Bountra, C. / Edwards, A.M. / Elkins, J.M. | ||||||
Citation | Journal: Acs Med.Chem.Lett. / Year: 2020 Title: Mining Public Domain Data to Develop Selective DYRK1A Inhibitors. Authors: Henderson, S.H. / Sorrell, F. / Bennett, J. / Hanley, M.T. / Robinson, S. / Hopkins Navratilova, I. / Elkins, J.M. / Ward, S.E. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 6s1i.cif.gz | 593.6 KB | Display | PDBx/mmCIF format |
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PDB format | pdb6s1i.ent.gz | 495.1 KB | Display | PDB format |
PDBx/mmJSON format | 6s1i.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/s1/6s1i ftp://data.pdbj.org/pub/pdb/validation_reports/s1/6s1i | HTTPS FTP |
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-Related structure data
Related structure data | 4mq1S S: Starting model for refinement |
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Similar structure data |
-Links
-Assembly
Deposited unit |
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Unit cell |
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Components on special symmetry positions |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Ens-ID: 1
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