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- PDB-6uip: DYRK1A Kinase Domain in Complex with a 6-azaindole Derivative, GN... -
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Basic information
Entry | Database: PDB / ID: 6uip | ||||||
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Title | DYRK1A Kinase Domain in Complex with a 6-azaindole Derivative, GNF2133. | ||||||
![]() | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | ||||||
![]() | TRANSFERASE / Kinase / Inhibitor | ||||||
Function / homology | ![]() histone H3T45 kinase activity / positive regulation of protein deacetylation / peptidyl-serine autophosphorylation / negative regulation of DNA methylation-dependent heterochromatin formation / dual-specificity kinase / [RNA-polymerase]-subunit kinase / negative regulation of microtubule polymerization / tau-protein kinase activity / negative regulation of DNA damage response, signal transduction by p53 class mediator / amyloid-beta formation ...histone H3T45 kinase activity / positive regulation of protein deacetylation / peptidyl-serine autophosphorylation / negative regulation of DNA methylation-dependent heterochromatin formation / dual-specificity kinase / [RNA-polymerase]-subunit kinase / negative regulation of microtubule polymerization / tau-protein kinase activity / negative regulation of DNA damage response, signal transduction by p53 class mediator / amyloid-beta formation / negative regulation of mRNA splicing, via spliceosome / G0 and Early G1 / peptidyl-tyrosine autophosphorylation / cytoskeletal protein binding / protein serine/threonine/tyrosine kinase activity / tubulin binding / RNA polymerase II CTD heptapeptide repeat kinase activity / positive regulation of RNA splicing / peptidyl-threonine phosphorylation / non-membrane spanning protein tyrosine kinase activity / tau protein binding / circadian rhythm / peptidyl-tyrosine phosphorylation / : / nervous system development / actin binding / peptidyl-serine phosphorylation / protein tyrosine kinase activity / protein autophosphorylation / transcription coactivator activity / cytoskeleton / protein kinase activity / nuclear speck / ribonucleoprotein complex / axon / protein phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / dendrite / positive regulation of DNA-templated transcription / nucleoplasm / ATP binding / identical protein binding / nucleus / cytoplasm Similarity search - Function | ||||||
Biological species | ![]() | ||||||
Method | ![]() ![]() ![]() | ||||||
![]() | DiDonato, M. / Spraggon, G. | ||||||
![]() | ![]() Title: Selective DYRK1A Inhibitor for the Treatment of Type 1 Diabetes: Discovery of 6-Azaindole Derivative GNF2133. Authors: Liu, Y.A. / Jin, Q. / Zou, Y. / Ding, Q. / Yan, S. / Wang, Z. / Hao, X. / Nguyen, B. / Zhang, X. / Pan, J. / Mo, T. / Jacobsen, K. / Lam, T. / Wu, T.Y. / Petrassi, H.M. / Bursulaya, B. / ...Authors: Liu, Y.A. / Jin, Q. / Zou, Y. / Ding, Q. / Yan, S. / Wang, Z. / Hao, X. / Nguyen, B. / Zhang, X. / Pan, J. / Mo, T. / Jacobsen, K. / Lam, T. / Wu, T.Y. / Petrassi, H.M. / Bursulaya, B. / DiDonato, M. / Gordon, W.P. / Liu, B. / Baaten, J. / Hill, R. / Nguyen-Tran, V. / Qiu, M. / Zhang, Y.Q. / Kamireddy, A. / Espinola, S. / Deaton, L. / Ha, S. / Harb, G. / Jia, Y. / Li, J. / Shen, W. / Schumacher, A.M. / Colman, K. / Glynne, R. / Pan, S. / McNamara, P. / Laffitte, B. / Meeusen, S. / Molteni, V. / Loren, J. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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PDBx/mmCIF format | ![]() | 487.6 KB | Display | ![]() |
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PDB format | ![]() | 339.6 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
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-Validation report
Summary document | ![]() | 1 MB | Display | ![]() |
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Full document | ![]() | 1 MB | Display | |
Data in XML | ![]() | 36.7 KB | Display | |
Data in CIF | ![]() | 48.4 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Related structure data | ![]() 2vx3S S: Starting model for refinement |
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Similar structure data |
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Assembly
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments:
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